Evidence-based strategy for dental biofilms: Current evidence of mouthwashes on dental biofilm and gingivitis

Abstract

SummaryTherapeutic mouthwash (MW) is an adjunctive tool along with a regular oral hygiene routine of daily tooth brushing and daily flossing. Previous systematic reviews have demonstrated that it is effective against dental biofilm and gingival inflammation, for prevention of dental caries, and for managing one’s bad breath condition according to the active ingredients. MWs prevent the microorganisms from bacterial adhesion that corresponds to the initial step in biofilm formation.This review summarized the current state of evidence such as anti-biofilm, anti-gingivitis and cariostatic properties of MWs by evaluating systematic reviews from the past six years. The anti-biofilm property has been proven to be effective, with strong evidence of three main clinical efficacies.The most commonly studied active agent was chlorhexidine gluconate (CHX), followed by essential oil (EO) and cetylpyridinium chloride. All the systematic reviews are in complete agreement that CHX and EO provide statistically significant improvements in terms of plaque and gingival indices. These effects have held up over the years as the number of studies has increased. While the use of fluoride MW is proven to be effective in improving the oral health of both children and adults, the quality of evidence is still regarded as low.

Clinical Trials with Herbal Products for the Prevention of Dental Caries and Their Quality: A Scoping Study

“…By far the dosage form most widely used in the studies under review was the mouth wash (MW) or mouth rinse (the two terms are for all practical purposes synonymous, but the official term in the European regulatory system is "mouth wash" [41]). This is in line with what other authors report (without a quantitative backing), e.g., "For many years, MW has been the most frequently tested vehicle for antimicrobial compounds" [42]. A critical review on how herbal products contributed to oral care (not exclusively focused on caries preventive herbals) also found similar By far the dosage form most widely used in the studies under review was the mouth wash (MW) or mouth rinse (the two terms are for all practical purposes synonymous, but the official term in the European regulatory system is "mouth wash" [41]).…”

“…A critical review on how herbal products contributed to oral care (not exclusively focused on caries preventive herbals) also found similar By far the dosage form most widely used in the studies under review was the mouth wash (MW) or mouth rinse (the two terms are for all practical purposes synonymous, but the official term in the European regulatory system is "mouth wash" [41]). This is in line with what other authors report (without a quantitative backing), e.g., "For many years, MW has been the most frequently tested vehicle for antimicrobial compounds" [42]. A critical review on how herbal products contributed to oral care (not exclusively focused on caries preventive herbals) also found similar results: 47.5% of the products included in that study were MWs, whereas toothpastes represented only 7.3% and oral gels 6.0% [43].…”

Clinical Trials with Herbal Products for the Prevention of Dental Caries and Their Quality: A Scoping Study

“…"For many years, MW has been the most frequently tested vehicle for antimicrobial compounds." [34]. A critical review on how herbal products contributed to oral care (not exclusively focused on caries preventive herbals) also found similar results: 47.5% of the products included in that study were MWs, whereas toothpastes represented only 7.3% and oral gels 6.0% [35].…”

COVID-19: A Recommendation to Examine the Effect of Mouthrinses with β-Cyclodextrin Combined with Citrox in Preventing Infection and Progression

“…Effective ingredients that may be applied in therapeutic mouth rinses includes: chlorhexidine (CHX), fluoride, cetylpyridinium chloride, essential oils, and peroxide [22]. Conceived for short-term usage, CHX 2% is a cationic bisbiguanide widely used in general medical practice as a broad-spectrum antiseptic.…”