Evidence-Based Use of Prokinetic Drugs for Abomasal Disorders in Cattle

Constable, Peter D.; Nouri, Mohammad; Şen, İsmai̇l; Baird, Aubrey N.; Wittek, Thomas

doi:10.1016/j.cvfa.2011.12.008

Cited by 20 publications

(14 citation statements)

References 64 publications

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“…In the experience of some authors, the abomasal emptying rate is decreased in cows with left displaced abomasums and is further decreased immediately after the surgical correction of left displaced abomasums (Wittek et al 2008;Constable et al 2012). Whether this is also the case in sheep after abomasal cannulation remains uncertain.…”

Section: Discussionmentioning

confidence: 97%

Laparoscopic abomasal cannulation in sheep

Zhang¹,

Fu²,

Y.³

et al. 2015

Vet. Med. - Czech

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Abomasal cannulation, an important research tool in experimental procedures, provides a method for the placement of an abomasal cannula in sheep. The aim of this study was to describe a technique for laparoscopic abomasal cannulation in sheep. It was performed in six anaesthetised sheep positioned in dorsal recumbency using three portals in the abdomen. The first absorbable traction suture was placed 1 cm cranial to the determined abomasal cannula site. A stab incision was made with a laparoscopic monopolar hook electrode in the middle of a purse-string suture placed around the abomasal cannula site. The T-shaped cannula was inserted into the abomasum lumen through the stab incision, and the second traction suture was then placed 1 cm caudal to the abomasal cannula site. The T-shaped abomasal cannula was pulled out of the abdominal cavity through the exit wound located 3-5 cm lateral and 10-12 cm cranial to the right side of the umbilicus. The two traction sutures were tied. The T-shaped cannula was secured to the skin with a finger-trap suture. Repeat laparoscopy was performed 1 month later. Firm adhesion between the abomasum and abdominal wall was observed in all sheep, with no evidence of leakage or peritonitis. No major intraoperative or postoperative complications were encountered. The median surgical time was 49 min, with a range from 42 to 58 min. The abomasal contents were collected easily. In conclusion, laparoscopic abomasal cannulation is safe and easy to perform. Its low complication rates and the "ideal" placement of the tube into the abomasum make it an especially attractive alternative to traditional surgical abomasal cannulation in veterinary practice.

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Section: Discussionmentioning

confidence: 97%

Laparoscopic abomasal cannulation in sheep

Zhang¹,

Fu²,

Y.³

et al. 2015

Vet. Med. - Czech

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“…An unexpected finding of this study was the minimal effect that oral erythromycin lactobionate (20 mg/kg BW) had on indices of abomasal emptying rate and the total IgG and total protein‐time relationships. Previous studies have consistently demonstrated that IM administration of erythromycin (8.8–10 mg/kg BW) produced a marked prokinetic effect in milk‐fed calves and adult cattle 5, 14, 15, 16, 17, 18, 19. Erythromycin base is not absorbed in preruminant calves when administered orally at 10 mg/kg; this result has been attributed to acid destruction of erythromycin in the abomasum 37.…”

Section: Discussionmentioning

confidence: 99%

“…We were, therefore, interested in determining the effect of potential nonantimicrobial prokinetic agents, such as cisapride and bethanechol, on abomasal emptying rate and AEA in neonatal calves, and in comparing their prokinetic effects to a positive control (erythromycin) and a negative control (0.9% NaCl solution). Erythromycin was selected as the positive control because it is known to be a strong prokinetic agent in milk‐fed calves and adult cattle 14, 15, 16, 17, 18, 19. Cisapride was investigated because it increases the rate of gastrointestinal motility in the cat, dog, and horse 20.…”

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confidence: 99%

Effect of Orally Administered Cisapride, Bethanechol, and Erythromycin on the Apparent Efficiency of Colostral IgG Absorption in Neonatal Holstein‐Friesian Calves

Ghoreishi

Nouri

Rasooli

et al. 2015

Veterinary Internal Medicne

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ObjectiveTo evaluate the effect of orally administered cisapride, bethanechol, and erythromycin on the absorption of colostral IgG in dairy calves.AnimalsTwenty‐four healthy neonatal Holstein‐Friesian calves.ProceduresCalves were randomly assigned to one of the following treatments: 0.9% NaCl solution (2 mL, PO; negative control); erythromycin lactobionate (20 mg/kg BW, PO; anticipated to be a positive control); cisapride (0.5 mg/kg BW, PO); bethanechol chloride (0.5 mg/kg BW, PO). Calves were fed 3 L of pooled bovine colostrum containing acetaminophen (50 mg/kg) by suckling and oroesophageal intubation 30 minutes after each treatment was administered. Jugular venous blood samples were obtained periodically after the start of feeding and plasma total IgG, protein, acetaminophen, and glucose concentrations determined. Abomasal emptying rate was assessed by the time to maximal plasma acetaminophen concentration.ResultsOral administration of cisapride facilitated the absorption of colostral IgG and protein. The effect of cisapride on abomasal emptying rate could not be evaluated because cisapride appeared to interfere with acetaminophen metabolism. Based on the total IgG and total protein concentration‐time relationships, the beneficial effects of cisapride appeared to occur early after oral administration and were transient.Conclusions and Clinical ImportanceAdditional studies appear indicated to characterize the effect of cisapride dose on the magnitude and duration of its effect on facilitating the absorption of colostral IgG and protein. Identification of a nonantimicrobial method for increasing abomasal emptying rate, such as cisapride, will potentially provide a practical and effective method for facilitating transfer of passive immunity in colostrum‐fed dairy calves.

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“…Podobne jak w publikacjach innych autorów (7,11,15,26), w badaniach własnych u żadnego z operowanych zwierząt nie obserwowano wzrostu ciepłoty wewnętrznej w okresie pooperacyjnym, w związku z powyższym nie było konieczności stosowania antybiotykoterapii, blokującej produkcję mleka.…”

Section: Ryc 5 Odgazowanie Trawieńca Przez Dostęp Narzędziowyunclassified

Application of a laparoscopic spieker of own design in reposition and fixation of the left displacement of the abomasum (LDA) in cattle.

Gnus

Ratajczak

Antosik

2018

Medycyna Weterynaryjna

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The first case of the left displacement of the abomasum was described in 1950 by Begg. Since then, the LDA has been diagnosed worldwide. It has been shown that there is a correlation between its increased occurrence and an increase in the intensity of cattle dairy production. The treatment methods include surgical ones, which are aimed at two objectives: reposition and fixation of the abomasum to the abdominal wall. The methods using the classic laparotomy include median abomasopexy, right-sided omentopexy and left-sided abomasopexy. A second group of surgical methods consists of procedures that are minimally invasive. These include percutaneous fixation, which requires positioning the patient on the back, and laparoscopic procedures performed by Janowicz and modified by Christiansen and later on by Newman. Recently, laparoscopic methods have become increasingly accessible and popular. The aim of the study was to evaluate the efficacy of laparoscopic treatment of the LDA, using equipment of the authors’ own design. The study involved the observation of 10 cows (aged between 24 and 90 months) treated surgically not later than 24 hours after the diagnosis. These animals were operated on with modified instruments. The modification presented here consisted in making a tube equipped with a trocar lock, which made it possible to reposition the abomasum non-traumatically and to fix it at the bottom of the abdomen. Signs of normal behaviour were observed, and all animals were eating and ruminating within 3-6 hours after surgery. The modification of the spieker proposed by the authors shortens laparoscopy and makes it safer by eliminating iatrogenic complications, such as accidental perforation of the bowels or diaphragm by the trocar edge..

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Evidence-Based Use of Prokinetic Drugs for Abomasal Disorders in Cattle

Cited by 20 publications

References 64 publications

Laparoscopic abomasal cannulation in sheep

Laparoscopic abomasal cannulation in sheep

Effect of Orally Administered Cisapride, Bethanechol, and Erythromycin on the Apparent Efficiency of Colostral IgG Absorption in Neonatal Holstein‐Friesian Calves

Application of a laparoscopic spieker of own design in reposition and fixation of the left displacement of the abomasum (LDA) in cattle.

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