Evidence for a causal relationship between the structure, size, and load of calcium pyrophosphate dihydrate crystals, and attacks of pseudogout.

Swan, A; Br, Heywood; Chapman, B. L.; Seward, H; Dieppe, Paul

doi:10.1136/ard.54.10.825

Cited by 47 publications

(32 citation statements)

References 16 publications

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“…The concentrations of CPP crystals used in this study are similar to those observed in synovial fluids collected during intercritical attacks of pseudogout and therefore reproduce a pathophysiological condition (Swan et al, 1995). …”

Section: Discussionsupporting

confidence: 69%

Epigallocatechin-3-gallate reduces inflammation induced by calcium pyrophosphate crystals in vitro

Oliviero¹,

Sfriso²,

Scanu³

et al. 2013

Front. Pharmacol.

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Although osteoarthritis (OA) is defined as a cartilage disease, synovitis involving mononuclear cell infiltration and overexpression of proinflammatory mediators is common in early and late OA. Calcium crystals deposition is thought to be a factor that likely contributes to synovial inflammation. In recent years, significant interest has emerged in the beneficial health effects attributed to the green tea polyphenols and in particular to epigallocatechin-3-gallate (EGCG). It has been demonstrated that some of the actions of EGCG are linked to its ability to interfere with cell membranes. The objective of this study was to evaluate the influence of EGCG in some inflammatory aspects of OA and whether EGCG is able to interfere with membrane organization. We assessed the effect of EGCG on the production of proinflammatory cytokines and chemokines released by human fibroblast-like synoviocytes (FLS) and THP-1 cells stimulated with calcium pyrophosphate (CPP) crystals in presence of methyl-β-cyclodextrin (MβCD), a cholesterol-removing agent that disturbs lipid raft structures. The chemotactic effect of culture supernatants was also evaluated. EGCG inhibited interleukin (IL)-1β, transforming growth factor beta, IL-8, and chemokine (C–C motif) ligand 2 (CCL2) release by stimulated FLS and/or THP-1 cells in a dose-dependent manner. Supernatants of CPP-stimulated cells induced the migration of neutrophils and mononuclear cells which decreased in a dose-dependent manner in the presence of EGCG. EGCG increased cell viability when added to THP-1 cells treated with MβCD. Furthermore, MβCD enhanced the inflammatory response to CPP crystals increasing IL-8 and CCL2 secretion which was inhibited by EGCG in a dose-dependent manner. This study showed that EGCG is able to reduce the inflammatory response induced by CPP crystals in vitro. The identification of EGCG as dietary supplement capable of affording protection or modulating the inflammatory response to CPP crystals may have important implications in the prevention and treatment of OA and crystal-related arthropathies.

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Section: Discussionsupporting

confidence: 69%

Epigallocatechin-3-gallate reduces inflammation induced by calcium pyrophosphate crystals in vitro

Oliviero¹,

Sfriso²,

Scanu³

et al. 2013

Front. Pharmacol.

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“…Morphological and crystallographic analysis showed that there was a greater crystal load, larger crystals, and a greater ratio of m-to t-CPPD crystals during the episode of the attack in comparison to the period in which the inflammation had subsided [55]. Morphological and crystallographic analysis showed that there was a greater crystal load, larger crystals, and a greater ratio of m-to t-CPPD crystals during the episode of the attack in comparison to the period in which the inflammation had subsided [55].…”

Section: Clinical Manifestation Morphology and Anatomical Locationsmentioning

confidence: 94%

Calcium Pyrophosphate Dihydrate Deposition Disease

Katsamenis¹,

Bouropoulos²

2015

Mineral Scales and Deposits

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“…Calcium pyrophosphate dihydrate (CPPD) crystal deposition in articular fibrocartilage and hyaline cartilage, termed “chondrocalcinosis,” is a common radiographic and pathologic finding associated with both aging and osteoarthritis (OA) (1). Most subjects with chondrocalcinosis are asymptomatic, but CPPD crystal deposition can promote articular cartilage degeneration (pseudo‐OA), and traffic of the crystals from articular cartilage into the joint space can stimulate acute synovitis (pseudogout) as well as chronic proliferative “pseudorheumatoid” synovitis (2).…”

mentioning

confidence: 99%

Lower prevalence of chondrocalcinosis in Chinese subjects in Beijing than in white subjects in the United States: The Beijing Osteoarthritis Study

Zhang

Terkeltaub

Nevitt

et al. 2006

Arthritis & Rheumatism

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Objective. Chondrocalcinosis, which can promote joint inflammation and cartilage degeneration, is highly prevalent in elderly white subjects. Data on its prevalence are scarce in other ethnic populations. This study was undertaken to compare the prevalence of chondrocalcinosis in Chinese subjects with that in white subjects.Methods. We recruited a random sample of Beijing residents ages >60 years. Participants underwent standard weight-bearing anteroposterior knee radiography and posteroanterior hand radiography using the protocols developed in the Framingham Osteoarthritis Study. Radiographic chondrocalcinosis was defined as present in a knee or wrist when there was evidence of definite linear cartilage calcification. We compared the prevalence of chondrocalcinosis in Chinese subjects with that in white subjects using age-standardized prevalence ratios. We used identical methods to collect samples of tap water from 2 cities and measured their levels of calcium, magnesium, and phosphate in the same laboratory.Results. Chinese subjects had a much lower prevalence of knee chondrocalcinosis (1.8% in men, 2.7% in women) than did white subjects (6.2% in men, 7.7% in women), with the age-standardized prevalence ratio Calcium pyrophosphate dihydrate (CPPD) crystal deposition in articular fibrocartilage and hyaline cartilage, termed "chondrocalcinosis," is a common radiographic and pathologic finding associated with both aging and osteoarthritis (OA) (1). Most subjects with chondrocalcinosis are asymptomatic, but CPPD crystal deposition can promote articular cartilage degeneration (pseudo-OA), and traffic of the crystals from articular cartilage into the joint space can stimulate acute syno-

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Evidence for a causal relationship between the structure, size, and load of calcium pyrophosphate dihydrate crystals, and attacks of pseudogout.

Abstract: [825][826][827][828][829][830]

Cited by 47 publications

References 16 publications

Epigallocatechin-3-gallate reduces inflammation induced by calcium pyrophosphate crystals in vitro

Epigallocatechin-3-gallate reduces inflammation induced by calcium pyrophosphate crystals in vitro

Calcium Pyrophosphate Dihydrate Deposition Disease

Lower prevalence of chondrocalcinosis in Chinese subjects in Beijing than in white subjects in the United States: The Beijing Osteoarthritis Study

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