Evidence for a conserved function of heart and neural crest derivatives expressed transcript 2 in mouse and human decidualization

Huyen, Doan Van; Bany, Brent M.

doi:10.1530/rep-11-0060

Cited by 71 publications

(71 citation statements)

References 52 publications

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“…HAND2 is robustly expressed in mouse uterine stroma by day 3 of gestation but is notably absent in the epithelium. Its stromal expression persists through the peri-implantation phase and is detectable until day 8.5 of pregnancy (92). Recent mouse genome-wide PGR binding studies indicated that Hand2 is a direct target of regulation by this receptor (22).…”

Section: Steroid-induced Epithelial-stromal Crosstalk Originating In mentioning

confidence: 99%

Minireview: Steroid-Regulated Paracrine Mechanisms Controlling Implantation

Pawar

Hantak

Bagchi

et al. 2014

Molecular Endocrinology

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Implantation is an essential process during establishment of pregnancy in mammals. It is initiated with the attachment of the blastocyst to a receptive uterine epithelium followed by its invasion into the stromal tissue. These events are profoundly regulated by the steroid hormones 17β-estradiol and progesterone. During the past several years, mouse models harboring conditional gene knockout mutations have become powerful tools for determining the functional roles of cellular factors involved in various aspects of implantation biology. Studies using these genetic models as well as primary cultures of human endometrial cells have established that the estrogen receptor α, the progesterone receptor, and their downstream target genes critically regulate uterine growth and differentiation, which in turn control embryo-endometrial interactions during early pregnancy. These studies have uncovered a diverse array of molecular cues, which are produced under the influence of estrogen receptor α and progesterone receptor and exchanged between the epithelial and stromal compartments of the uterus during the progressive phases of implantation. These paracrine signals are critical for acquisition of uterine receptivity and functional interactions with the embryo. This review highlights recent work describing paracrine mechanisms that govern steroid-regulated uterine epithelial-stromal dialogue during implantation and their roles in fertility and disease.

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Section: Steroid-induced Epithelial-stromal Crosstalk Originating In mentioning

confidence: 99%

Minireview: Steroid-Regulated Paracrine Mechanisms Controlling Implantation

Pawar

Hantak

Bagchi

et al. 2014

Molecular Endocrinology

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“…3C) and/or heart and neural crest derivatives expressed 2 (Hand2)? A recently described bHLH transcription factor required for decidualization [50,51], Hand2 has yet to be matched with an endometrial interacting partner. 4) Does abrogation of Tcf23 in the mouse uterus cause …”

Section: Role Of Tcf23 In Endometrial Decidualizationmentioning

confidence: 99%

A Murine Uterine Transcriptome, Responsive to Steroid Receptor Coactivator-2, Reveals Transcription Factor 23 as Essential for Decidualization of Human Endometrial Stromal Cells1

Kommagani

Szwarc

Kovancı

et al. 2014

Biology of Reproduction

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Recent data from human and mouse studies strongly support an indispensable role for steroid receptor coactivator-2 (SRC-2)-a member of the p160/SRC family of coregulators-in progesterone-dependent endometrial stromal cell decidualization, an essential cellular transformation process that regulates invasion of the developing embryo into the maternal compartment. To identify the key progesterone-induced transcriptional changes that are dependent on SRC-2 and required for endometrial decidualization, we performed comparative genome-wide transcriptional profiling of endometrial tissue RNA from ovariectomized SRC-2(flox/flox) (SRC-2(f/f) [control]) and PR(cre/+)/SRC-2(flox/flox) (SRC-2(d/d) [SRC-2-depleted]) mice, acutely treated with vehicle or progesterone. Although data mining revealed that only a small subset of the total progesterone-dependent transcriptional changes is dependent on SRC-2 (∼13%), key genes previously reported to mediate progesterone-driven endometrial stromal cell decidualization are present within this subset. Along with providing a more detailed molecular portrait of the decidual transcriptional program governed by SRC-2, the degree of functional diversity of these progesterone mediators underscores the pleiotropic regulatory role of SRC-2 in this tissue. To showcase the utility of this powerful informational resource to uncover novel signaling paradigms, we stratified the total SRC-2-dependent subset of progesterone-induced transcriptional changes in terms of novel gene expression and identified transcription factor 23 (Tcf23), a basic-helix-loop-helix transcription factor, as a new progesterone-induced target gene that requires SRC-2 for full induction. Importantly, using primary human endometrial stromal cells in culture, we demonstrate that TCF23 function is essential for progesterone-dependent decidualization, providing crucial translational support for this transcription factor as a new decidual mediator of progesterone action.

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“…PR directly induces HAND2 expression in human stromal cells (Mazur et al 2015 ). In mice, HAND2 is expressed in the endometrial stroma at day 3 of pregnancy, consistent with PR-dependent induction (Huyen and Bany 2011 ). Importantly, uterine ablation of Hand2 expression ( PR…”

Section: The Role Of Stromal Pr In Er Antagonismmentioning

confidence: 71%

The Role of Steroid Hormone Receptors in the Establishment of Pregnancy in Rodents

Adams

DeMayo

2015

Advances in Anatomy, Embryology and Cell Biology

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The ovarian hormones, estrogen and progesterone, and their receptors, the estrogen receptor (ER) and progesterone receptor (PR), orchestrate the complex sequence of events required for uterine receptivity and the establishment of pregnancy. The actions of ER, PR, and other steroid hormone receptors (SHRs) direct the uterus through the processes of implantation and decidualization. Due to the ethical concerns of studying pregnancy in humans, genetically engineered rodent models have facilitated many of the discoveries that have elucidated the molecular events directing early pregnancy. This chapter will cover the conserved structure and function of the SHRs. ER and PR will be highlighted for their pivotal roles in uterine receptivity, implantation, and decidualization. The dynamic regulation of ER and PR expression and activity throughout the estrous cycle and early pregnancy, and the importance of SHRs in coordinating paracrine signaling between the endometrial compartments will also be explored. Finally, the roles of androgen receptor (AR) and glucocorticoid receptor (GR) in the establishment of pregnancy will be discussed.

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Evidence for a conserved function of heart and neural crest derivatives expressed transcript 2 in mouse and human decidualization

Cited by 71 publications

References 52 publications

Minireview: Steroid-Regulated Paracrine Mechanisms Controlling Implantation

Minireview: Steroid-Regulated Paracrine Mechanisms Controlling Implantation

A Murine Uterine Transcriptome, Responsive to Steroid Receptor Coactivator-2, Reveals Transcription Factor 23 as Essential for Decidualization of Human Endometrial Stromal Cells1

The Role of Steroid Hormone Receptors in the Establishment of Pregnancy in Rodents

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