Evidence for a dopaminergic control of sympathoadrenal catecholamine release

Mercuro, Giuseppe; Gessa, G L; Rivano, C. A.; Lai, L; Cherchi, A

doi:10.1016/0002-9149(88)91236-2

Cited by 11 publications

(1 citation statement)

References 6 publications

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“…In anaesthetized and vagotomized dogs with electrically stimulated splanchnic nerves, the dopamine D2-like receptor agonist, quinpirole, had an inhibitory effect, while the dopamine D2-like receptor antagonist, domperidone, had a stimulatory effect on norepinephine (NE) and epinephrine (EP) release (Foucart et al, 1988). Stimulation of NE and EP release was induced in humans by domperidone during exercise (Mercuro et al, 1988;Mannelli et al, 1988) or after glucagon stimulation (Mannelli et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

Roles of Dopaminergic D₁and D₂Receptors in Catecholamine Release from the Rat Adrenal Medulla

Baek

Seo

Lim

2008

Korean J Physiol Pharmacol

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The aim of the present study was designed to establish comparatively the inhibitory effects of D1-like and D2-like dopaminergic receptor agonists, SKF81297 and R(-)-TNPA on the release of catecholamines (CA) evoked by cholinergic stimulation and membrane depolarization from the isolated perfused model of the rat adrenal medulla. SKF81297 (30μM) and R-(-)-TNPA (30μM) perfused into an adrenal vein for 60 min, produced great inhibition in the CA secretory responses evoked by ACh (5.32×10

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Section: Introductionmentioning

confidence: 99%

Roles of Dopaminergic D₁and D₂Receptors in Catecholamine Release from the Rat Adrenal Medulla

Baek

Seo

Lim

2008

Korean J Physiol Pharmacol

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Effects of 1-Year’s Therapy with the Dopamine2 Agonist Dihydroergotoxine on Blood Pressure and Plasma Noradrenaline Levels in Essential Hypertension

et al. 1992

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SummaryAlthough there is considerable evidence that the acute administration of peripheral presynaptic dopamine [dopamine-2 (02)] receptor agonists inhibits the sympathetic neuronal release of noradrenaline (norepinephrine) and decreases arterial blood pressure (BP), their effects on the sympathetic system and on cardiovascular function after long term treatment in patients with hypertension are not known. 12 patients with essential hypertension received a selective 02 receptor agonist, dihydroergotoxine 9 to 13.5 mg/day orally for I year after a preliminary single-blind placebo period of 4 weeks. Oihydroergotoxine reduced systolic and diastolic BP, heart rate and plasma noradrenaline levels, and these effects persisted for up to 1 year. The fall in BP significantly correlated with the decrease in circulating noradrenaline levels during treatment (p < 0.01).Oihydroergotoxine did not inhibit the physiological rise in plasma noradrenaline levels induced by standing and was not associated with orthostatic hypotension. The development of tolerance to dihydroergotoxine was not observed, and coupled with the lack of adverse effects, suggests 02 receptor agonists may be clinically useful in the long term treatment of essential hypertension.

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Plasma neurotransmitters, blood pressure, and heart rate during supine-resting, orthostasis, and moderate exercise conditions in major depressed patients

Lechín¹,

Dijs²,

Orozco³

et al. 1995

Biological Psychiatry

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Evidence for a dopaminergic control of sympathoadrenal catecholamine release

Cited by 11 publications

References 6 publications

Roles of Dopaminergic D₁and D₂Receptors in Catecholamine Release from the Rat Adrenal Medulla

Roles of Dopaminergic D₁and D₂Receptors in Catecholamine Release from the Rat Adrenal Medulla

Effects of 1-Year’s Therapy with the Dopamine2 Agonist Dihydroergotoxine on Blood Pressure and Plasma Noradrenaline Levels in Essential Hypertension

Plasma neurotransmitters, blood pressure, and heart rate during supine-resting, orthostasis, and moderate exercise conditions in major depressed patients

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Evidence for a dopaminergic control of sympathoadrenal catecholamine release

Cited by 11 publications

References 6 publications

Roles of Dopaminergic D1and D2Receptors in Catecholamine Release from the Rat Adrenal Medulla

Roles of Dopaminergic D1and D2Receptors in Catecholamine Release from the Rat Adrenal Medulla

Effects of 1-Year’s Therapy with the Dopamine2 Agonist Dihydroergotoxine on Blood Pressure and Plasma Noradrenaline Levels in Essential Hypertension

Plasma neurotransmitters, blood pressure, and heart rate during supine-resting, orthostasis, and moderate exercise conditions in major depressed patients

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Product

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Roles of Dopaminergic D₁and D₂Receptors in Catecholamine Release from the Rat Adrenal Medulla

Roles of Dopaminergic D₁and D₂Receptors in Catecholamine Release from the Rat Adrenal Medulla