2022
DOI: 10.1016/j.exer.2022.109005
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Evidence for a phenotypic switch in corneal afferents after lacrimal gland excision

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Cited by 8 publications
(4 citation statements)
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“…L-carnitine (1 mmol/L) was already shown to suppress TRPV1 functional expression in excitable corneal nociceptive innervated neurons [38][39][40]. Our current study is unique since either 1 or 3 mmol/L of L-carnitine blocked each of the three different hallmarks of TRPV1 activation in HCE-T cells, as illustrated in Figure 5.…”
Section: Modes Of Suppression Of Trpv1 Activation By L-carnitinementioning
confidence: 52%
“…L-carnitine (1 mmol/L) was already shown to suppress TRPV1 functional expression in excitable corneal nociceptive innervated neurons [38][39][40]. Our current study is unique since either 1 or 3 mmol/L of L-carnitine blocked each of the three different hallmarks of TRPV1 activation in HCE-T cells, as illustrated in Figure 5.…”
Section: Modes Of Suppression Of Trpv1 Activation By L-carnitinementioning
confidence: 52%
“…In pathological contexts, studies have described such phenotypic plasticity, likely promoting corneal wound healing. For example, increased CGRP expression in corneal neurons of a dry eye disease mouse model was demonstrated 57 and similar increase was seen with TRPM8 axonal expression in an abrasion model 58 . Our staining of differents types of fibres at 3 months showed that SP+ fibres were decreased in OPA1 +/- epithelium.…”
Section: Discussionmentioning
confidence: 65%
“…25 Long ciliary nerve ligation led to an increase of CGRP-positive cells in the TG, which was consistent with previous studies involving a partial lacrimal gland resection model. 16,45 This study found that the mRNA levels of ion channels TRPV1, TRPM8, and Piezo2 significantly increased after LCN ligation. This not only explains the mechanism of different types of corneal pain induced by LCN ligation but also verifies that the proposed method can also induce typical neurochemical changes of peripheral corneal sensitization.…”
Section: Discussionmentioning
confidence: 79%
“…There are some limitations to this study. First, although sex differences are important in pain processing regarding male and female subjects, respectively, 45 our research was based on male subjects only. In the future, we plan to investigate the role of gender differences in LCN ligation–induced pain.…”
Section: Discussionmentioning
confidence: 99%