Evidence for a relationship between recovery from anaesthesia, modified state of consciousness and striatal voltammetric levels of ascorbic acid

Crespi, Francesco; Möbius, Claudia; Keane, P.E.

doi:10.1016/1043-6618(92)90705-g

Cited by 8 publications

(5 citation statements)

References 30 publications

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“…l -Ascorbic acid, vitamin C, is an extremely important biological molecule with many roles including enzyme cofactor, reducing agent, involvement in neurotransmitter-related enzymes and, of course, essential nutritional factor. − Various techniques have been employed for its measurement, − with a special need to develop in vivo methods.…”

mentioning

confidence: 99%

“…Electrochemical methods have long been used to determine ascorbic acid either directly − or combined with other techniques. − The direct application of cyclic voltammetry (CV) on solid electrodes or more sensitive differential pulse voltammetry (DPV) also allows in vivo measurements . Voltammetric techniques however, require a three-electrode potentiostatic system and periodic regeneration of the working electrode to obtain reproducible responses.…”

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confidence: 99%

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Detection of Ascorbic Acid Using a Carbon Fiber Microelectrode Coated with Cobalt Tetramethylpyridoporphyrazine

et al. 1996

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confidence: 99%

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confidence: 99%

Detection of Ascorbic Acid Using a Carbon Fiber Microelectrode Coated with Cobalt Tetramethylpyridoporphyrazine

et al. 1996

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“…Vitamin C is a water-soluble vitamin that is necessary for a variety physiological reactions such as adrenaline production and collagen synthesis [5] . Previous animal studies have showed that there is a close relationship between extracellular vitamin C levels and recovery from anesthesia [6] .…”

Section: Introductionmentioning

confidence: 99%

Beyaz Yeni Zelanda Tavşanlarında Vitamin C Premedikasyonu Sonrasında Ksilazin-Ketamin Anestezisi

Yanmaz¹,

Şenocak²,

DOĞAN³

et al. 2015

Kafkas Univ Vet Fak Derg

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This study was aimed out to evaluate the effects of vitamin C premedication on xylazine-ketamine anesthesia in New Zealand white rabbits. Twelve New Zealand white rabbits were divided into two groups (Group XK and Group VCXK) that each had 3 males and 3 females. The animals in group XK were treated with 10 mg/kg Xylazine HCl and 50 mg/kg Ketamine HCl. The animals in group VCXK were pre-treated with 60 mg/kg Vitamin C prior to xylazine-ketamine combination. The onset of anesthesia, the length of surgical anesthesia and the recovery time were recorded. Body temperature, heart and respiratory rates were recorded at 0,5,10,15, 30, 45, 60 min. In XK group onset of action and length of surgical anesthesia were 5.81±0.19 min and 55.00±2.81 min, respectively. Premedication of rabbits with 60 mg/kg vitamin C resulted in significant decrease in the onset of action (3.93±0.13 min) and increase in the duration of xylazine-ketamine anesthesia (77.50±6.15 min). The body temperature change between treatment groups were significant at 30, 45 and 60 min. This study shows that vitamin C administration prior to xylazine-ketamine anesthesia in New Zealand white rabbits decreases the time for onset of action and prolonged the length of surgical anesthesia. Keywords: Xylazine, Ketamine, Anesthesia, Vitamin C, Recovery, New Zealand white rabbit Beyaz Yeni Zelanda Tavşanlarında Vitamin C Premedikasyonu Sonrasında Ksilazin-Ketamin Anestezisi ÖzetBu çalışma, beyaz Yeni Zelanda tavşanlarında xylazine-ketamine anestezisi üzerine vitamin C premedikasyonunun etkilerini değerlendirmeyi amaçladı. On-iki beyaz Yeni Zelenda tavşanı her grupta 3 erkek ve 3 dişi olacak şekilde iki gruba (Grup XK ve Grup VCXK) ayrıldı. Grup XK'daki hayvanlara 10 mg/kg Xylazine HCl ve 50 mg/kg Ketamin HCl uygulandı. Grup VCXK'daki hayvanlara Xylazine-Ketamine kombinasyonu öncesinde, 60 mg/kg Vitamin C verildi. Anestezi başlangıcı, cerrahi anestezi süresi ve uyanma zamanı kaydedildi. Vücut sıcaklığı, kalp frekansı ve solunum oranları 0, 5, 10, 15, 30, 45 ve 60. dakikalarda

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“…A finding incidental to the hypotheses, but of concern in surgical patients, was a subset of 10 participants who had plasma ascorbic acid levels so low that they could not be measured. While generalization of the findings from this study to other populations must be done with caution, study findings should arouse concern among health care providers because wound healing is delayed in patients with below normal levels of ascorbic acid when compared to patients with normal levels of ascorbic acid (Arnold & Barbul, 2006;Crespi, Mobius, & Keane, 1992;Mandal, 2006;Tanaka, 1999).…”

Section: Discussionmentioning

confidence: 84%

Ascorbic Acid Does Not Influence Consciousness Recovery After Anesthesia

Talley

Wicks

Carter

et al. 2008

Biological Research For Nursing

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Several studies have examined the influence of general anesthesia on changes in consciousness and unconscious cognitive processes. However, much remains to be learned about potential moderators of general anesthetic agents, such as antioxidants including ascorbic acid, and their influence on the recovery of consciousness following general anesthesia. General anesthesia potentially affects plasma ascorbic acid levels and may impair consciousness during the postoperative period; however, published literature regarding these relationships is equivocal. Ascorbic acid is important for brain function and may be related to the return of postoperative consciousness through action on the synaptic receptors in the brain. This study was designed as a pretest-posttest repeated measures investigation. Ascorbic acid levels were measured at four time periods in patients (N = 50) undergoing surgery and general anesthesia. Following surgery, patients were administered a paper-and-pencil measure of concentration that served as an index of post-anesthesia consciousness. The results suggest that changes occur in plasma ascorbic acid levels at different time points during the anesthesia regimen in nonemergent surgical patients. No statistically significant relationships were found between plasma ascorbic acid levels and improved post-anesthesia consciousness, suggesting that ascorbic acid does not influence recovery of consciousness following general anesthesia.

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Evidence for a relationship between recovery from anaesthesia, modified state of consciousness and striatal voltammetric levels of ascorbic acid

Cited by 8 publications

References 30 publications

Detection of Ascorbic Acid Using a Carbon Fiber Microelectrode Coated with Cobalt Tetramethylpyridoporphyrazine

Detection of Ascorbic Acid Using a Carbon Fiber Microelectrode Coated with Cobalt Tetramethylpyridoporphyrazine

Beyaz Yeni Zelanda Tavşanlarında Vitamin C Premedikasyonu Sonrasında Ksilazin-Ketamin Anestezisi

Ascorbic Acid Does Not Influence Consciousness Recovery After Anesthesia

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