1994
DOI: 10.3109/15419069409004452
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Evidence for a Role of the Epithelial Glycoprotein 40 (Ep-CAM) in Epithelial Cell-Cell Adhesion

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Cited by 128 publications
(116 citation statements)
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“…This was already suggested by the fact that Rac/Pi3K activation induced disassembly of cadherin-mediated adhesions. The same findings have been described for Ep-CAM expression [13][14][15]. As previously described, both Ep-CAM and p85, the regulatory subunit of Pi3K, are capable to bind a-actinin, although under different conditions [11,16].…”
Section: Discussionsupporting
confidence: 84%
“…This was already suggested by the fact that Rac/Pi3K activation induced disassembly of cadherin-mediated adhesions. The same findings have been described for Ep-CAM expression [13][14][15]. As previously described, both Ep-CAM and p85, the regulatory subunit of Pi3K, are capable to bind a-actinin, although under different conditions [11,16].…”
Section: Discussionsupporting
confidence: 84%
“…This name is proposed to be EpCAM (without a dash) as an abbreviation for the ability of the protein to act as an epithelial-specific cell adhesion molecule (Litvinov et al, 1994) and activating molecule (Munz et al, 2004;Osta et al, 2004). It is also suggested to add in brackets on the first occurrence of the EpCAM name in a text the recently introduced cellular differentiation (CD) marker nomenclature for EpCAM, namely CD326.…”
mentioning
confidence: 99%
“…Accessibility of EpCAM-expressing cells to both antibodies and immune effector cells may further increase upon degradation of extracellular matrix by tumor cellderived proteases and by loss of tight junctions in tumor tissue. In support for a sequestration of EpCAM in normal epithelia, immunohistochemical studies showed that EpCAM is concentrated within intercellular boundaries, whereas it is evenly distributed on the surface of tumor cells (46). There may in fact be three Figure 3.…”
Section: Murine-specific Epcam Bitementioning
confidence: 97%