1977
DOI: 10.1016/0022-4804(77)90140-8
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Evidence for a role of the stomach in serum calcium regulation

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Cited by 16 publications
(6 citation statements)
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“…Thus, the present results and those of Kaplan et al (1 8) would suggest that the calcium loss in the gastric secretions may, in part, be responsible for the hypocalcemic response to gastrin. In addition, this confirmed the fact that gastrininduced hypocalcemia was not via calcitonin, since calcitonin has been reported to reduce gastric secretion (6,18). The increase in total calcium in the gastric juice may be the result of the direct action of gastrin on calcium transport mechanisms of the gastric mucosa per se or the purely physical properties of an increase in calcium solubility in a more acidic medium.…”
Section: Results the Hypocalcemic Effect Of Gastrinsupporting
confidence: 77%
“…Thus, the present results and those of Kaplan et al (1 8) would suggest that the calcium loss in the gastric secretions may, in part, be responsible for the hypocalcemic response to gastrin. In addition, this confirmed the fact that gastrininduced hypocalcemia was not via calcitonin, since calcitonin has been reported to reduce gastric secretion (6,18). The increase in total calcium in the gastric juice may be the result of the direct action of gastrin on calcium transport mechanisms of the gastric mucosa per se or the purely physical properties of an increase in calcium solubility in a more acidic medium.…”
Section: Results the Hypocalcemic Effect Of Gastrinsupporting
confidence: 77%
“…Neither exogenous nor endogenous gastrins seem to stimulate the release of calcitonin in the rat (2), and the hypocalcemic response evoked by gastrin-17 must therefore have another explanation. Schulak and Kaplan (1) and Kaplan et al (3) were first to report that thyroparathyroidectomy and parathyroidectomy had no effect on the gastrin-evoked hypocalcemia while gastrectomy or fundectomy prevented it. Krishnamra and Limlomwongse (8) and Limlomwongse and Krishnamra (9) suggested that neither gastric secretion of calcium nor renal elimination of calcium could explain the gastrin-evoked hypocalcemia.…”
Section: Methodsmentioning
confidence: 99%
“…2). Gastrectomy or resection of the proximal stomach inhibited the hypocalcemic response to gastrin (1,3,4), indicating that the proximal stomach mediated the response. The present study examines the mechanism by which gastrin induces hypocalcemia and the role played by the proximal stomach.…”
mentioning
confidence: 99%
“…In spite of the importance of gastrectomy-induced osteoporosis, very little is known about the influence of the gastric mucosa on bone metabolism. Since the experimental studies of IVY (15) , who described bone loss in gastrectomized dogs, many studies have demonstrated that the gastric mucosa is related in some way to the incorporation of calcium into bone (19,20,23,31,32,37) . Despite the accepted role of gastric acid secretion in maintaining calcium absorption, the treatment of rats with a potent proton pump inhibitor resulting in almost complete achlorhydria had no effect on bone density, and, in addition, parenteral calcium supplementation did not prevent bone mineral loss in gastrectomized animals (32) .…”
Section: Bone Mineral Density Gastric Mucosa Atrophy and Hp Infectionmentioning
confidence: 99%