Evidence for a specific role for muscarinic receptors in crossmodal object recognition in rats

Jacklin, Derek L.; Kelly, Patrick A.; Bianchi, Cristina; MacDonald, Tyler; Traquair, Hugh; Winters, Boyer D.

doi:10.1016/j.nlm.2014.11.017

Cited by 9 publications

(8 citation statements)

References 64 publications

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“…To study how different sensations contribute to object recognition memory, researchers have tried to dissect the visual (by presenting objects behind transparent barriers, which prevents physical contact), tactile (by presenting objects under red light, which masks the animals' vision) and visualtactile interaction (tactile condition for learning, followed by visual condition for testing, or vice versa, called cross-modal object recognition; CMOR) effects (Winters and Reid, 2010). This and related issues (Hu et al, 2018) have been studied by a series of systematic experiments based on the CMOR test (Gaynor et al, 2018;Jacklin et al, 2016;Jacklin et al, 2012;Jacklin et al, 2015;Paylor et al, 2018;Reid et al, 2012Reid et al, , 2014. The interaction between sensations and object recognition is an important topic, but will not be addressed here as it is beyond the scope of this review.…”

Section: Basic Concepts and Methodological Factors For Measuring Object- Place- Time-and Episodic-memory Based On Object Exploration 21 Nmentioning

confidence: 99%

The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties

Chao

Silva

Yang

et al. 2020

Neuroscience & Biobehavioral Reviews

113

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Rats and mice have been demonstrated to show episodic-like memory, a prototype of episodic memory, as defined by an integrated memory of the experience of an object or event, in a particular place and time. Such memory can be assessed via the use of spontaneous object exploration paradigms, variably designed to measure memory for object, place, temporal order and object-location inter-relationships. We review the methodological properties of these tests, the neurobiology about time and discuss the evidence for the involvement of the medial prefrontal cortex (mPFC), entorhinal cortex (EC) and hippocampus, with respect to their anatomy, neurotransmitter systems and functional circuits. The systematic analysis suggests that a specific circuit between the mPFC, lateral EC and hippocampus encodes the information for event, place and time of occurrence into the complex episodic-like memory, as a top-down regulation from the mPFC onto the hippocampus. This circuit can be distinguished from the neuronal component memory systems for processing the individual information of object, time and place.

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Section: Basic Concepts and Methodological Factors For Measuring Object- Place- Time-and Episodic-memory Based On Object Exploration 21 Nmentioning

confidence: 99%

The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties

Chao

Silva

Yang

et al. 2020

Neuroscience & Biobehavioral Reviews

113

View full text Add to dashboard Cite

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“…Because the effortful, top-down inhibitory processes are thought to be cholinergically mediated 17 , they are particularly vulnerable to the cholinergic decline associated with healthy aging, as well as to the cholinergic disruption that characterises neurodegenerative conditions, such as Mild Cognitive Impairment (MCI) and Alzheimer’s disease (AD). It is important to note that such a link between cholinergic activity and multisensory processes has been established in rodents 18 , with a particularly prominent role in multisensory memory formation and retrieval 19 , 20 . Thus, disruptions in cholinergic processing likely contribute to further alterations in multisensory processing during abnormal aging, which could potentially have diagnostic value, if gauged appropriately.…”

Section: Introductionmentioning

confidence: 98%

Sensory dominance and multisensory integration as screening tools in aging

Murray

Eardley

Edginton

et al. 2018

Sci Rep

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Multisensory information typically confers neural and behavioural advantages over unisensory information. We used a simple audio-visual detection task to compare healthy young (HY), healthy older (HO) and mild-cognitive impairment (MCI) individuals. Neuropsychological tests assessed individuals’ learning and memory impairments. First, we provide much-needed clarification regarding the presence of enhanced multisensory benefits in both healthily and abnormally aging individuals. The pattern of sensory dominance shifted with healthy and abnormal aging to favour a propensity of auditory-dominant behaviour (i.e., detecting sounds faster than flashes). Notably, multisensory benefits were larger only in healthy older than younger individuals who were also visually-dominant. Second, we demonstrate that the multisensory detection task offers benefits as a time- and resource-economic MCI screening tool. Receiver operating characteristic (ROC) analysis demonstrated that MCI diagnosis could be reliably achieved based on the combination of indices of multisensory integration together with indices of sensory dominance. Our findings showcase the importance of sensory profiles in determining multisensory benefits in healthy and abnormal aging. Crucially, our findings open an exciting possibility for multisensory detection tasks to be used as a cost-effective screening tool. These findings clarify relationships between multisensory and memory functions in aging, while offering new avenues for improved dementia diagnostics.

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“…our results, both studies found that rats were able to differentiate between categories and generalize to novel exemplars. Given the well-established role of ACh receptors in object memory and perception (Barker & Warburton, 2009;Bartko et al, 2014;Jacklin et al, 2015;Mitchnick et al, 2018;Warburton et al, 2003;Winters, Bartko, Saksida, & Bussey, 2007), as well as impaired visual categorization in macaques following scopolamine treatment (Aggelopoulos, Liebe, Logothetis, & Rainer, 2011), we predicted impairing effects of scopolamine on OCR task performance by mice. Indeed, prechoice systemic scopolamine administration significantly impaired OCR in the experimental group.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, prechoice systemic scopolamine administration significantly impaired OCR in the experimental group. Muscarinic receptors do not appear to be necessary for object memory retrieval, as pretest scopolamine does not typically affect standard SOR performance in rodents (Jacklin et al, 2015; Warburton et al, 2003; Winters, Saksida, & Bussey, 2006) or delayed nonmatching-to-sample (DNMS) performance in monkeys (Aigner & Mishkin, 1986; Aigner, Walker, & Mishkin, 1991; Tang, Mishkin, & Aigner, 1997). The present scopolamine result with OCR is comparable to impairments in CMOR and VIOR induced by prechoice scopolamine (Jacklin et al, 2015; Mitchnick et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…The neurotransmitter acetylcholine (ACh) has been strongly implicated in the acquisition and encoding of new information (Hasselmo, 2006). We have previously demonstrated that cholinergic activity at muscarinic ACh receptors, during the choice phase, is required for tactile-visual CMOR (Jacklin et al, 2015), as well as VIOR (Mitchnick et al, 2018). We suggest that ACh at muscarinic receptors is necessary for the binding of object features across modalities and rotational perspectives.…”

mentioning

confidence: 99%

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Development of an “object category recognition” task for mice: Involvement of muscarinic acetylcholine receptors.

Creighton¹,

Collett²,

Zonneveld³

et al. 2019

Behavioral Neuroscience

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Recent research suggests that rats are capable of object categorization-like processes. To study whether mice possess similar abilities, we developed a spontaneous one-trial object category recognition (OCR) task. Based on the spontaneous object recognition paradigm, mice discriminated between two otherwise equally novel objects, one from a novel category and one from a studied category. During the sample phase, mice were exposed to two different exemplars from the same category. After a retention delay, they explored a third (i.e., novel) object from that sampled category and an object from a novel category in a choice phase. Mice preferentially explored the novel category object, taken as an index of category recognition, in this OCR task when a 30-min retention delay was used. Extensive preexposure to category exemplar objects also enhanced subsequent task performance across a longer (1-h) retention delay at which mice without preexposure did not demonstrate evidence for category recognition. Prechoice administration of the acetylcholine muscarinic receptor antagonist, scopolamine, disrupted OCR performance with or without preexposure, implicating acetylcholine in category recognition. The current study presents a valuable new rodent task for the study of the mechanistic basis of categorization-like processes and its potential relevance to common cognitive disorders.

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Evidence for a specific role for muscarinic receptors in crossmodal object recognition in rats

Cited by 9 publications

References 64 publications

The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties

The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties

Sensory dominance and multisensory integration as screening tools in aging

Development of an “object category recognition” task for mice: Involvement of muscarinic acetylcholine receptors.

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