Evidence for Adrenaline in Adrenergic Neurones

Cannon, W. B.; Lissák, K

doi:10.1152/ajplegacy.1939.125.4.765

Cited by 106 publications

(18 citation statements)

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“…Cannon and Lissak (2) in 1939 found that cat hearts contained a sympathomimetic substance which they concluded to be adrenaline. Shaw (3) found that mammalian heart extracts contained an adrenalinelike substance which gave an arsenomolybdate color reaction.…”

mentioning

confidence: 99%

Effect of Cervico-Thoracic Ganglionectomy on the Adrenaline and Noradren Aline Content in the Mammalian Heart1

Goodall¹,

Kirshner²

1956

J. Clin. Invest.

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mentioning

confidence: 99%

Effect of Cervico-Thoracic Ganglionectomy on the Adrenaline and Noradren Aline Content in the Mammalian Heart1

Goodall¹,

Kirshner²

1956

J. Clin. Invest.

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“…Other observations emphasized the importance of such storage in limiting the vasopressor action of NE. Sympathetic denervation that produces a fall in tissue NE content (22,23) and inability of the denervated tissue to bind circulating NE (24) had long been known to be followed by hypersensitivity to injected catecholamines (25). Diminution of NE stores by reserpine and other drugs was similarly associated with increased reactivity to NE (26,27).…”

Section: Discussionmentioning

confidence: 99%

Plasma Clearance of dl-β-H3-Norepinephrine in Normal Human Subjects and Patients with Essential Hypertension*

Gitlow¹,

Mendlowitz²,

Wilk³

et al. 1964

J. Clin. Invest.

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In 1936 hemodynamic measurements in patients with essential hypertension suggested the presence of a functional increase in peripheral vasoconstriction producing an abnormally high peripheral resistance to blood flow (1). The concept that physiologic degrees of vasoconstriction were maintained by the adrenergic neurohumor, norepinephrine (NE), was proposed almost simultaneously (2), but it was nearly 10 years later that von Euler (3, 4), Holtz, Credner, and Kroneberg (5), and others demonstrated that NE was normally present in and released by mammalian sympathetic nerves. Within a year, Goldenberg and co-workers (6) suggested that essential hypertension might be caused by the simple overproduction of NE. This neurohumoral theory underwent repeated evaluation, first by the measurement of NE in urine (7, 8) and plasma (9), and later by the assay in urine of the major NE catabolites, vanillylmandelic acid (VMA) (10), normetanephrine (NM) (11), and 3-methoxy, 4-hydroxyphenyl glycol (NMG) (12).Since no clear-cut evidence of NE overproduction could be found (8-10), and since physiologic studies suggested that essential hypertension was associated with abnormally increased vascular reactivity to infused NE (13), it seemed possible that the disease might be causally related to abnormal metabolic handling of that NE produced in normal quantities by these patients. To evaluate the metabolism of a substance that underwent degradation within moments of its administration and which produced an intense physiologic effect in nanogram amounts, a tracer compound of high

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“…Как оказалось в результате крупного открытия выдающегося физиолога В.Кеннона существует закономерность реакции лишенных иннервации тканей, именуемая «Закон денервации. Повыше-ние чувствительности денервированных структур» [21, [72][73][74]. Закон В Кеннона гласит: «Если в ряду эфферентных нейронов разрушается какая-ли-бо единица, то в изолированной структуре или структурах развивается повышенная раздражи-мость к действию химических веществ, причем в непосредственно денервированных участках этот эффект максимален» [21, стр.…”

Section: Abstract: Ontogenesis Of the Nervous System Sudden Cardiacunclassified

“…Исследования В.Кеннона с основным соав-тором -А.Розенблютом, а также с А.Сименоном и Г.Рамос [72][73][74] [73,74,80] было установлено ускорение ритма сокращений денервированного сердца после удаления симпатических нервных узлов и введения экспериментальным животным адреналина и экстракта передней доли гипофиза. В результате авторами описывается возникающая фибрилляция денервированных мышц сердца и формулируется закон повышения их чувствитель-ности при сочетанных нарушениях центральной и периферической нервной системы [21].…”

Section: Abstract: Ontogenesis Of the Nervous System Sudden Cardiacunclassified

The morpho-functional diagnostics of age-related neurodystrophic changing in the organism, which preceded sudden cardiac death

Shvalev¹,

Rogoza²,

Сергиенко³

et al. 2016

MV-MN

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Evidence for Adrenaline in Adrenergic Neurones

Cited by 106 publications

References 0 publications

Effect of Cervico-Thoracic Ganglionectomy on the Adrenaline and Noradren Aline Content in the Mammalian Heart1

Effect of Cervico-Thoracic Ganglionectomy on the Adrenaline and Noradren Aline Content in the Mammalian Heart1

Plasma Clearance of dl-β-H3-Norepinephrine in Normal Human Subjects and Patients with Essential Hypertension*

The morpho-functional diagnostics of age-related neurodystrophic changing in the organism, which preceded sudden cardiac death

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