Evidence for Alterations in Lipid Profiles and Biophysical Properties of Lipid Rafts From Spinal Cord in Amyotrophic Lateral Sclerosis
Mario Diaz,
Noemi Fabelo,
Virginia Martin
et al.
Abstract:Amyotrophic Lateral Sclerosis (ALS) is an age-dependent neurodegenerative disease affecting motor neurons in the spinal cord and brainstem whose etiopathogenesis remains unclear. Recent studies have linked major neurodegenerative diseases with altered function of multimolecular lipid-protein complexes named lipid rafts. In the present study, we have isolated lipid rafts from the anterior horn of the spinal cords of controls and ALS individuals, and analysed their lipid composition. We found that ALS affects le… Show more
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