Evidence for association between hepatitis C virus seropositivity and coronary artery disease

Vassalle, Cristina; Masini, Silvia; Bianchi, Fabrizio; Zucchelli, G.C.

doi:10.1136/hrt.2003.018937

Cited by 160 publications

(149 citation statements)

References 6 publications

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“…19,20 More limited data are also available from European studies. 21,22 In a preliminary study, we found that the prevalence of intima-media thickening (>1 mm) in carotid arteries was significantly higher (P < 0.001) in 31 non-cirrhotic HCV-positive patients than in 120 age-matched HCV-negative controls, thus confirming previous observations. Using multivariate regression analysis, HCV infection remained an independent risk factor for carotid atherosclerosis.…”

Section: Introductionsupporting

confidence: 78%

Hepatitis C virus RNA localization in human carotid plaques

Boddi

Abbate

Chellini

et al. 2010

Journal of Clinical Virology

131

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a b s t r a c tBackground: Hepatitis C virus (HCV) infection has certain characteristics that enable it to play an important role in atherosclerosis. Some studies report its association with an increased risk of carotid artery plaque. Objectives: The aim of this study was to evaluate the presence of HCV genomic sequences and replicative intermediates in plaque tissues. Study Design: A cohort of consecutive, prospectively recruited patients with HCV infection and chronic ischemic heart disease from the Cardiology, Vascular Surgery and Hepatology Units of a University Hospital in Florence, Italy, were studied. Results: Positive-strand HCV RNA was detected in seven carotid plaque tissues from anti-HCV-positive patients and was not detected in the nine carotid plaque tissues obtained from anti-HCV-negative patients. In three patients, HCV RNA was found in carotid plaque and not in serum. HCV replicative intermediates were detected in three plaque samples. Direct sequencing of HCV RNA from the plaque and serum showed HCV genotypes 2 (five cases) and 1 (two cases). Conclusions: The novel finding of HCV RNA sequences in plaque tissue strongly suggests an active local infection. This in turn makes it conceivable that the virus may exert local action in carotid atherosclerosis.

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Section: Introductionsupporting

confidence: 78%

Hepatitis C virus RNA localization in human carotid plaques

Boddi

Abbate

Chellini

et al. 2010

Journal of Clinical Virology

131

View full text Add to dashboard Cite

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“…3 Similar associations were reported in another earlier reported study. 1 In the current study we were able to show that HCV-seropositive status is a strong predictor for CAD in addition to other traditional factors such as age, DM, tobacco dependence and family history of CAD. Although in the multivariate model DM and family history of CAD could not reach statistical significance likely a result of small sample size.…”

Section: Discussionsupporting

confidence: 52%

“…[1][2][3] Reports of a negative association between HCV infection and CAD have further compounded any meaningful inferences. [4][5][6] Reports of an increased risk [1][2][3] or an increase in measures of subclinical atherosclerosis have fueled continued interest to further explore any such associations. [7][8][9] One of the major drawbacks of the earlier negative studies was the lack of well-designed controls and failure to control for the risk factors associated with CAD.…”

mentioning

confidence: 99%

Higher Prevalence and More Severe Coronary Artery Disease in Hepatitis C Virus-infected Patients: A Case Control Study

Satapathy

Kim

Kataria

et al. 2013

Journal of Clinical and Experimental Hepatology

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Background: An association of Coronary artery disease (CAD) with hepatitis C (HCV) has been suggested, but definitive data are still lacking. Aim: Our study sought to estimate the prevalence and severity of CAD in HCV patients compared to with age-, sex-, and race-matched controls without HCV infection. Subjects and methods: 63 HCV-infected patients were compared with 63 age, race, and sex-matched controls without HCV infection undergoing coronary angiography for evaluation of CAD. CAD was defined as more than a 50% blockage in any of the proximal coronary arteries on angiogram. The severity of the stenosis was defined by the modified Reardon severity scoring system: <50% stenosis of the luminal diameter, 1 point; 50-74%, 2 points; 75-99%, 3 points; 100% or total obstruction, 4 points. The points for each lesion in the proximal coronary circulation were summed to give the score for severity. Results: A significantly higher prevalence of CAD was noted in the HCV population (69.8% vs. 47.6%, = 0.01). The combined Reardon's severity score in the HCV group was significantly higher compared to the controls (6.26 ± 5.39 vs. 2.6 ± 3.03, P < 0.0005). Additionally, significant multivessel CAD (>50% stenosis and $2 vessels involved) was also noted significantly more commonly in the HCV group compared to controls (57.1% vs. 15.9%, P < 0.0005). Conclusion: In this retrospective study the prevalence and severity of CAD was higher in HCV patients who were evaluated for CAD by angiogram compared with matched non-HCV patients. HCV-positive status is potentially a risk factor for CAD. ( J CLIN EXP HEPATOL 2013;3: 186-191)

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“…It became apparent over a decade ago that HCV might be considered as a risk factor for the development of coronary artery disease (CAD) (9). In 2012, a systematic review of the literature suggested an increased risk of CAD in HCV-infected individuals (10).…”

Section: Hcv and Atherosclerosismentioning

confidence: 99%

Hepatitis C virus and atherosclerosis: A legacy after virologic cure?

Bassendine

Nielsen

Bridge

et al. 2017

Clinics and Research in Hepatology and Gastroenterology

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We discuss possible factors involved in the aetiopathogenesis of atherosclerosis in chronic HCV and hypothesise that an important mechanism underlying the development of AS is the presence of circulating low-density immune complexes that induce an inflammatory response.We suggest that HCV particles may be inducing an antibody response to lipoproteins present in the lipo-viral particles and sub-viral particles -a concept similar to the more general 'autoantibody' response to modified LDL.After virologic cure some AS risk factors will recede but an increase in serum cholesterol could result in progression of early atherosclerotic lesions, leaving a legacy from persistent HCV infection that has clinical and therapeutic implications.

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Evidence for association between hepatitis C virus seropositivity and coronary artery disease

Cited by 160 publications

References 6 publications

Hepatitis C virus RNA localization in human carotid plaques

Hepatitis C virus RNA localization in human carotid plaques

Higher Prevalence and More Severe Coronary Artery Disease in Hepatitis C Virus-infected Patients: A Case Control Study

Hepatitis C virus and atherosclerosis: A legacy after virologic cure?

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