Evidence for Association of Endothelial Nitric Oxide Synthase Gene in Subjects with Glaucoma and a History of Migraine

Logan, J F J; Chakravarthy, Usha; Hughes, Anne E.; Patterson, Chris; Jackson, Jonathan; Rankin, Simon J. A.

doi:10.1167/iovs.05-0368

Cited by 58 publications

(40 citation statements)

References 25 publications

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“…In the overall analysis, we observed a marginal difference in the frequency of this polymorphism among cases and controls, which was not significant after adjustments for other variables of interest. These results are in accordance with the findings observed by other authors (Fan et al, 2010;Lin et al, 2005;Logan et al, 2005). The Glu298Asp polymorphism, in turn, has been associated with risk of ischemic shock (Berger et al, 2007), coronary spasm (Yoshimura et al, 1998), coronary artery disease (Colombo et al, 2003;Hingorani et al, 1999), myocardial infarction (Hibi et al, 1998;Shimasaki et al, 1998) and NAION (Sakai et al, 2007).…”

Section: Discussionsupporting

confidence: 92%

“…While some studies have implicated polymorphisms in the promoter region or inside the eNOS in the risk of POAG (Ayub et al, 2010;Liao et al, 2011;Tunny et al, 1998), other authors found no significant association (Fan et al, 2010;Lin et al, 2005;Logan et al, 2005). Interestingly, recent reports indicate that these different polymorphisms could interact with other exposure factors in modulating the risk of POAG, such as gender, use of postmenopausal hormones (PMHs), hypertension and smoking (Kang et al, 2010(Kang et al, , 2011.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of polymorphisms of endothelial nitric oxide synthase (eNOS) gene with the risk of primary open angle glaucoma in a Brazilian population

Silva

Rocha

Lacchini

et al. 2012

Gene

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Association of polymorphisms of endothelial nitric oxide synthase (eNOS) gene with the risk of primary open angle glaucoma in a Brazilian population

Silva

Rocha

Lacchini

et al. 2012

Gene

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“…However, relatively more consistent associations are observed with genetic studies of eNOS-related factors and POAG. [62][63][64][65][66][67] Although not all studies have found associations with variants in the NOS3 gene that codes for eNOS, 68,69 variants or haplotypes of SNPs in NOS3 have been reported to be associated with POAG overall, 62,65 POAG with migraines, 66 POAG or high tension POAG among women only, 63,64 and familial POAG. 67 Furthermore, the CAV1/CAV2 gene region, which codes for caveolins that control eNOS activity, contain variants associated with POAG in one GWAS, 24 and this finding was replicated in another large candidate gene study.…”

Section: Discussionmentioning

confidence: 99%

Vascular tone pathway polymorphisms in relation to primary open-angle glaucoma

Kang

Loomis

Yaspan³

et al. 2014

Eye

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“…The 27-bp VNTR has been associated with variations in plasma levels of nitric oxide and its metabolites [16,17]. The association between eNOS mRNA levels and the 4-repaet allele appeared to be dosedependent [18].…”

Section: Discussionmentioning

confidence: 94%

Endothelial nitric oxide synthase VNTR (intron 4 a/b) polymorphism association with nonsyndromic oral clefts

Lakkakula¹,

Gurramkonda²,

Lakkakula³

et al. 2013

Turk J Bioch

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Objective: Nonsyndromic cleft lip with or without cleft palate (NSCLP) is a common birth defect with substantial clinical and social impact, and whose causes include both genetic and environmental factors. Folate and homocysteine metabolism have been indicated to play a role in the etiology of NSCLP. The aim of this study was to determine the prevalence of NOS3 27-bp VNTR and to evaluate whether this polymorphism contributed to the risk of NSCLP. Material and methods:We studied the 27 base pair tandem repeat polymorphism in intron 4 of the endothelial nitric oxide synthase (NOS3) gene in 230 unrelated individuals belong to 7 Indian populations along with 141 NSCLP cases and 142 unrelated controls. The genotyping was performed by polymerase chain reaction and electrophoresis. The data were statistically analysed using the χ 2 -test. Results: The NOS3 27-bp VNTR 4a allele is present in six of the seven populations analysed and allele frequencies range from 6.8% in Sugali to 23.5% in Madiga populations. NOS3 showed protective association with predisposition towards NSCLP for the heterozygous (4b/a) genotypes (4b/b vs. 4b/a: OR =0.58, 95% CI =0.34 to 0.99, p=0.044). Conclusions:The current study suggests significant differences in the frequency of the NOS3 VNTR allele across the populations. There is protective association between NOS3 27-bp VNTR polymorphism and NSCLP in the Indian population. Key Words: nitric oxide, NOS3, VNTR polymorphism, orofacial clefts, Indians Conflict of Interest: The authors declare that they have no competing interests.. ÖZETAmaç: Semptomatik olmayan damak yarıklı veya yarıksız yarık dudak (NSCLP) olguları sosyal ve klinik etkisi ağır olan ve çok sık rastlanan bir doğum bozukluğu olup, genetik ve çevresel etkenlere bağlıdır. NSCLP etiyolojisinde folat ve homosistin metabolizmalarının etkin olduğu endike edilmiştir. Bu çalışmanın amacı NOS3 27 bp VNTR sıklığının belirlenmesi ve bu polimorfizmin NSCLP için bir risk faktörü olma olasılığının araştırılmasıdır. Materyal ve metod: Hindistanda bulunan 7 toplumdan 141 NSCLP ve 142 ilişkisiz kontrol olmak üzere 230 ilişkilendirlmemiş bireyde nitrik oksit sentaz geninin intron 4 bölgesinde bulunan 27 bazlık ardışık tekrar polimorfizmi incelenmiştir. Genotiplendirme polimeraz zincir reaksiyonu ve elektroforez ile gerçekleştirilmiştir. Istatistiksel veri analizi χ 2 -testi ile yapılmıştır. Bulgular: NOS3 27-bp VNTR 4a alleli incelenen 7 toplumdan altısında bulunmakta ve allel sıklıkları Sugali toplumunda %6.8'den Madiga toplumunda %23.5'e kadar değişmektedir. NOS3 koruyucu assosiyasyon, heterezigot 4b/a genotipleri (4b/b vs. 4b/a: OR = 0.58, 95% CI = 0.34 to 0.99, p=0.044) için NSCLP'e yatkınlık gözlemlenmiştir. Sonuç: Bu çalışmada toplumlar arasında NOS3 VNTR allel sklığında belirgin farklılıklar göstermektedir. Hint toplumu için NOS3 27-bp VNTR polimorfismi ve NSCLP arasında koruyucu asosiyasyon bulunmaktadır. Anahtar Kelimeler: nitrik oksit, NOS3, VNTR polimorfizmi, orofasiyal cepler, Hintliler Çıkar Çatışması: Yazarların çıkar çatışması ...

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Evidence for Association of Endothelial Nitric Oxide Synthase Gene in Subjects with Glaucoma and a History of Migraine

Abstract: This study provides evidence of an association between the NOS3 gene and subjects with glaucoma who have a history of migraine. Unlike in other studies, no evidence was found of an association between ET-1 and glaucoma.

Cited by 58 publications

References 25 publications

Association of polymorphisms of endothelial nitric oxide synthase (eNOS) gene with the risk of primary open angle glaucoma in a Brazilian population

Association of polymorphisms of endothelial nitric oxide synthase (eNOS) gene with the risk of primary open angle glaucoma in a Brazilian population

Vascular tone pathway polymorphisms in relation to primary open-angle glaucoma

Endothelial nitric oxide synthase VNTR (intron 4 a/b) polymorphism association with nonsyndromic oral clefts

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