Evidence for chronic lung impairment in patients treated for pulmonary tuberculosis

Vecino, Mauricio; Pasipanodya, Jotam G.; Slocum, Philip; Bae, Sejong; Munguia, Guadalupe; Miller, Thaddeus L.; Fernandez, Michel; Drewyer, Gerry; Weis, Stephen E.

doi:10.1016/j.jiph.2011.08.005

Cited by 36 publications

(39 citation statements)

References 24 publications

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“…Patients with disease with a sympatric host-pathogen relationship were more likely to have no impairment. Previously, we showed that PIAT is more frequent and severe in certain risk groups and racial/ethnic populations and also demonstrated that PIAT could be life-long (Pasipanodya et al, 2010(Pasipanodya et al, , 2012bVecino et al, 2011). In these studies, self-reported non-Hispanic white was associated with PIAT, while various measures of socio-economic status were not.…”

Section: Discussionmentioning

confidence: 87%

“…Approximately 2 million persons die annually from tuberculosis (TB) and among those that survive, at least half will experience pulmonary impairment after TB (PIAT) that can be debilitating (Pasipanodya et al, 2007(Pasipanodya et al, , 2010Vecino et al, 2011;World Health Organization, 2010). Previous studies have described host, pathogen, environmental, and lifestyle factors associated with outcomes after TB exposure, after latent Mycobacterium tuberculosis infection, or after TB disease (Blaser and Kirschner, 2007;Caws et al, 2008;Coscolla and Gagneux, 2010;Kato-Maeda et al, 2001;Malik and Godfrey-Faussett, 2005;Pasipanodya et al, 2012b;van Crevel et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Allopatric tuberculosis host–pathogen relationships are associated with greater pulmonary impairment

Pasipanodya

Moonan

Vecino

et al. 2013

Infection, Genetics and Evolution

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Background-Host pathogen relationships can be classified as allopatric, when the pathogens originated from separate, non-overlapping geographic areas from the host; or sympatric, when host and pathogen shared a common ancestral geographic location. It remains unclear if hostpathogen relationships, as defined by phylogenetic lineage, influence clinical outcome. We sought to examine the association between allopatric and sympatric phylogenetic Mycobacterium tuberculosis lineages and pulmonary impairment after tuberculosis (PIAT).

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Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Allopatric tuberculosis host–pathogen relationships are associated with greater pulmonary impairment

Pasipanodya

Moonan

Vecino

et al. 2013

Infection, Genetics and Evolution

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“…Post-pulmonary tuberculosis impairment was studied after 20 weeks of tuberculosis treatment and again on, or after, treatment completion 32 . The median duration between the first and the second spirometry was 15 weeks.…”

Section: Functional Evaluation Of Sequelaementioning

confidence: 99%

Is there a rationale for pulmonary rehabilitation following successful chemotherapy for tuberculosis?

et al. 2016

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The role of tuberculosis as a public health care priority and the availability of diagnostic tools to evaluate functional status (spirometry, plethysmography, and DLCO determination), arterial blood gases, capacity to perform exercise, lesions (chest X-ray and CT), and quality of life justify the effort to consider what needs to be done when patients have completed their treatment. To our knowledge, no review has ever evaluated this topic in a comprehensive manner. Our objective was to review the available evidence on this topic and draw conclusions regarding the future role of the "post-tuberculosis treatment" phase, which will potentially affect several million cases every year. We carried out a non-systematic literature review based on a PubMed search using specific keywords (various combinations of the terms "tuberculosis", "rehabilitation", "multidrug-resistant tuberculosis", "pulmonary disease", "obstructive lung disease", and "lung volume measurements"). The reference lists of the most important studies were retrieved in order to improve the sensitivity of the search. Manuscripts written in English, Spanish, and Russian were selected. The main areas of interest were tuberculosis sequelae following tuberculosis diagnosis and treatment; "destroyed lung"; functional evaluation of sequelae; pulmonary rehabilitation interventions (physiotherapy, long-term oxygen therapy, and ventilation); and multidrug-resistant tuberculosis.The evidence found suggests that tuberculosis is definitively responsible for functional sequelae, primarily causing an obstructive pattern on spirometry (but also restrictive and mixed patterns), and that there is a rationale for pulmonary rehabilitation. We also provide a list of variables that should be discussed in future studies on pulmonary rehabilitation in patients with post-tuberculosis sequelae.

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“…Due to the destructive nature of TB, pulmonary TB may induce chronic lung impairment (2). Despite effective TB therapy, the healing process following resolution of active TB can lead to structural damage to the lung parenchyma and airways (3).…”

Section: Introductionmentioning

confidence: 99%

The Definition of Past Tuberculosis Affects the Magnitude of Association between Pulmonary Tuberculosis and Respiratory Dysfunction: Korea National Health and Nutrition Examination Survey, 2008–2012

Choi

Lee

et al. 2017

J Korean Med Sci

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Tuberculosis (TB) is associated with an increased risk of chronic lung impairment. The aim of this study was to compare the clinical characteristics and lung functions according to definition of past TB. We used the population-based, Korea National Health and Nutrition Examination Survey (KNHANES) (2008–2012) to analyze 13,522 subjects age 40 years or older who underwent spirometry and chest X-ray (CXR). Subjects with TB lesions on CXR (with or without a history of TB) were older, more likely to be male, ever smokers, and of low socioeconomic status than subjects with only a history of TB or without evidence of TB. Airflow obstruction (AFO) was associated with only a history of TB (odds ratio [OR] 1.53, 95% confidence interval [CI] 0.95–2.46), only TB lesion on CXR (OR 2.37, 95% CI 1.80–3.12), and both a history and TB lesions on CXR (OR 4.47, 95% CI 3.07–6.51) after adjustment for gender, age, body mass index, education, income, and smoking amount (P for trend < 0.001). Spirometric restriction was associated with only a history of TB (OR 1.29, 95% CI 0.80–2.08), only TB lesions on CXR (OR 2.03, 95% CI 1.49–2.76), and both a history and TB lesions on CXR (OR 2.65, 95% CI 1.74–4.05) after adjustment for the above variables (P for trend < 0.001). How to define past TB in population study affects the magnitude of association between past TB and respiratory dysfunction. Without considering TB lesions on CXR, the association between TB and respiratory dysfunction could be underestimated.

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Evidence for chronic lung impairment in patients treated for pulmonary tuberculosis

Cited by 36 publications

References 24 publications

Allopatric tuberculosis host–pathogen relationships are associated with greater pulmonary impairment

Allopatric tuberculosis host–pathogen relationships are associated with greater pulmonary impairment

Is there a rationale for pulmonary rehabilitation following successful chemotherapy for tuberculosis?

The Definition of Past Tuberculosis Affects the Magnitude of Association between Pulmonary Tuberculosis and Respiratory Dysfunction: Korea National Health and Nutrition Examination Survey, 2008–2012

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