Evidence for clock genes circadian rhythms in human full-term placenta

Pérez, Silvia; Murias, L.; Fernández-Plaza, Catalina; Dı́az, Irene; González, Celestino; Otero, Jesús María Garagorri; Dı́az, Elena

doi:10.3109/19396368.2015.1069420

Cited by 34 publications

(31 citation statements)

References 39 publications

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“…Remarkably, and unlike mouse pregnancy, we did not detect any oscillation patterns in clock genes in term human placentas, which is not consistent with previous studies of placentas from vaginal deliveries ( 42 ). This discrepancy may be because we used placentas from elective cesarean sections.…”

Section: Discussioncontrasting

confidence: 99%

Gestational disruptions in metabolic rhythmicity of the liver, muscle, and placenta affect fetal size

et al. 2017

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Maternal metabolic adaptations are essential for successful pregnancy outcomes. We investigated how metabolic gestational processes are coordinated, whether there is a functional link with internal clocks, and whether disruptions are related to metabolic abnormalities in pregnancy, by studying day/night metabolic pathways in murine models and samples from pregnant women with normally grown and large-for-gestational age infants. In early mouse pregnancy, expression of hepatic lipogenic genes was up-regulated and uncoupled from the hepatic clock. In late mouse pregnancy, rhythmicity of energy metabolism-related genes in the muscle followed the patterns of internal clock genes in this tissue, and coincided with enhanced lipid transporter expression in the fetoplacental unit. Diurnal triglyceride patterns were disrupted in human placentas from pregnancies with large-for-gestational age infants and this overlapped with an increase in BMAL1 expression. Metabolic adaptations in early pregnancy are uncoupled from the circadian clock, whereas in late pregnancy, energy availability is mediated by coordinated muscle-placenta metabolic adjustments linked to internal clocks. Placental triglyceride oscillations in the third trimester of human pregnancy are lost in large-for-gestational age infants and may be regulated by BMAL1. In summary, disruptions in metabolic and circadian rhythmicity are associated with increased fetal size, with implications for the pathogenesis of macrosomia.—Papacleovoulou, G., Nikolova, V., Oduwole, O., Chambers, J., Vazquez-Lopez, M., Jansen, E., Nicolaides, K., Parker, M., Williamson, C. Gestational disruptions in metabolic rhythmicity of the liver, muscle, and placenta affect fetal size.

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Section: Discussioncontrasting

confidence: 99%

Gestational disruptions in metabolic rhythmicity of the liver, muscle, and placenta affect fetal size

et al. 2017

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“…This "master clock" relies on the functional role of the core clock proteins, Clock and Bmal1, which enables clock gene expression. As mentioned before, these circadian clock genes are all expressed in animal and human placenta, and their expression shows a potential circadian rhythm [26,57]. Several studies have shown the crucial role that the circadian clock and SCN play in female reproductive function [21,22,58].…”

Section: Embryonic Brain Scnmentioning

confidence: 84%

“…It should be noted, however, that external effects cannot be ruled out, such as the stress of vaginal delivery, including the increase in stress hormones known to affect gene expression. Only two of the genes studied-Clock and Bmal1, showed any circadian variation [26].…”

Section: Future Directions and Perspectivesmentioning

confidence: 92%

“…Disruption of the clock genes has also been implicated in a variety of malfunctions of homeostasis, including glucose, and lipid metabolism [17][18][19][20]. Several circadian clock genes such as Clock, Bmal1, Per2, and Cry1 are expressed in human and animal full-term placenta tissue, suggesting a potential circadian rhythm [21][22][23][24][25][26]. As demonstrated in prior research, the relationships between the placenta and fetal circadian signals are complex and are essential for the development of a successful pregnancy.…”

Section: Introductionmentioning

confidence: 92%

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Circadian Clock, Time-Restricted Feeding and Reproduction

Pan

Taylor

Cohen

et al. 2020

IJMS

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The goal of this review was to seek a better understanding of the function and differential expression of circadian clock genes during the reproductive process. Through a discussion of how the circadian clock is involved in these steps, the identification of new clinical targets for sleep disorder-related diseases, such as reproductive failure, will be elucidated. Here, we focus on recent research findings regarding circadian clock regulation within the reproductive system, shedding new light on circadian rhythm-related problems in women. Discussions on the roles that circadian clock plays in these reproductive processes will help identify new clinical targets for such sleep disorder-related diseases.

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“…Besides, other organs (e.g., placenta) may play a direct role. Full-term placenta expresses circadian rhythms of Clock and Bmal1 ( 72 ), and clock gene polymorphisms are associated with placental abruption ( 73 ) and even a single polymorphism of Bmal1 is associated with an increase in miscarriages ( 27 ). Finally, RNA microarray analysis of human milk fat globules indicates differential daily expression of 7% of transcripts ( 74 ).…”

Section: Translational Importance Of Circadian Rhythms and Clock Genementioning

confidence: 99%

Circadian Rhythms and Clock Genes in Reproduction: Insights From Behavior and the Female Rabbit’s Brain

2018

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Clock gene oscillations are necessary for a successful pregnancy and parturition, but little is known about their function during lactation, a period demanding from the mother multiple physiological and behavioral adaptations to fulfill the requirements of the offspring. First, we will focus on circadian rhythms and clock genes in reproductive tissues mainly in rodents. Disruption of circadian rhythms or proper rhythmic oscillations of clock genes provoke reproductive problems, as found in clock gene knockout mice. Then, we will focus mainly on the rabbit doe as this mammal nurses the young just once a day with circadian periodicity. This daily event synchronizes the behavior and the activity of specific brain regions critical for reproductive neuroendocrinology and maternal behavior, like the preoptic area. This region shows strong rhythms of the PER1 protein (product of the Per1 clock gene) associated with circadian nursing. Additionally, neuroendocrine cells related to milk production and ejections are also synchronized to daily nursing. A threshold of suckling is necessary to entrain once a day nursing; this process is independent of milk output as even virgin does (behaving maternally following anosmia) can display circadian nursing behavior. A timing motivational mechanism may regulate such behavior as mesolimbic dopaminergic cells are entrained by daily nursing. Finally, we will explore about the clinical importance of circadian rhythms. Indeed, women in chronic shift-work schedules show problems in their menstrual cycles and pregnancies and also have a high risk of preterm delivery, making this an important field of translational research.

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Evidence for clock genes circadian rhythms in human full-term placenta

Cited by 34 publications

References 39 publications

Gestational disruptions in metabolic rhythmicity of the liver, muscle, and placenta affect fetal size

Gestational disruptions in metabolic rhythmicity of the liver, muscle, and placenta affect fetal size

Circadian Clock, Time-Restricted Feeding and Reproduction

Circadian Rhythms and Clock Genes in Reproduction: Insights From Behavior and the Female Rabbit’s Brain

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