Evidence for Conservation of the Vasopressin/Oxytocin Superfamily in Annelida

Satake, Honoo; Takuwa, Kyoko; Minakata, Hiroyuki; Matsushima, Osamu

doi:10.1074/jbc.274.9.5605

Cited by 77 publications

(59 citation statements)

References 42 publications

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“…Indeed, several studies indicate that the classification of the OT/VP superfamily based on the residue at position 8 does not make sense in invertebrates (Van Kesteren et al 1995a, 1995bSatake et al 1999), and that, instead, residues 2-5 are essential for high-affinity binding and biological efficacy Kanda et al 2005). OT-like and VP-like peptides and their receptors have been identified in diverse groups such as annelids (Salzet et al 1993;Oumi et al 1994;Levoye et al 2005), arthropods (Proux et al 1987;Li et al 2008;Stafflinger et al 2008), and molluscs (Cruz et al 1987;Reich 1992;Van Kesteren et al 1992;Takuwa-Kuroda et al 2003;Kanda et al 2005).…”

Section: Introductionmentioning

confidence: 98%

Distribution of oxytocin-like and vasopressin-like immunoreactivities within the central nervous system of the cuttlefish, Sepia officinalis

et al. 2009

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We have investigated the distribution of oxytocin/vasopressin (OT/VP) superfamily peptides in the central nervous system (CNS) of the cuttlefish, Sepia officinalis, by using antibodies raised against mammalian OT and VP. Several populations of OT-like and VP-like immunoreactive cell bodies and fibers were widely distributed in cerebral structures involved in learning processes (vertical lobe complex, optic lobes), behavioral communication (peduncle, lateral basal and chromatophore lobes), feeding behavior (inferior frontal, brachial and buccal lobes), sexual activity (dorsal basal, subpedunculate, olfactory lobes), and metabolism (visceral lobes). The two most remarkable findings of this study were the occurrence of OT-like immunoreactivity in many amacrine cells of the vertical lobe and the dense accumulation of VP-like immunoreactive cell bodies in the subpedunculate 1 lobe. No double-immunolabeled cell bodies or fibers were found in any lobes of the CNS, indicating, for the first time in a decapod cephalopod mollusc, the existence of distinct oxytocinergic-like and vasopressinergic-like systems. The widespread distribution of the immunoreactive neurons suggests that these OT-like and VP-like peptides act as neurotransmitters or neuromodulators.

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Section: Introductionmentioning

confidence: 98%

Distribution of oxytocin-like and vasopressin-like immunoreactivities within the central nervous system of the cuttlefish, Sepia officinalis

et al. 2009

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“…The Ciona digestive tracts were dissected and fixed in Bouin's fluid at 4°C overnight. Preparation of 5-m serial sections, hybridization, washing, and detection were carried out as previously reported (34). No positive signals were observed when sense probes were used, confirming the specificity of hybridization.…”

Section: Functional Analysis Of Ci-tk-r Expressed In Xenopusmentioning

confidence: 99%

Tachykinin and Tachykinin Receptor of an Ascidian, Ciona intestinalis

Satake

Ogasawara

Kawada

et al. 2004

Journal of Biological Chemistry

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Tachykinins (TKs) are the most prevalent vertebrate brain/gut peptides. In this study, we originally identified authentic TKs and their receptor from a protochordate, Ciona intestinalis. The Ciona TK (Ci-TK) precursor, like mammalian ␥-preprotachykinin A (␥-PPTA), encodes two TKs, Ci-TK-I and -II, including the -FXGLM-NH 2 vertebrate TK consensus. Mass spectrometry of the neural extract revealed the production of both Ci-TKs. Ci-TK-I contains several Substance P (SP)-typical amino acids, whereas a Thr is exceptionally located at position 4 from the C terminus of Ci-TK-II. The Ci-TK gene encodes both Ci-TKs in the same exon, indicating no alternative generation of Ci-TKs, unlike the PPTA gene. These results suggested that the alternative splicing of the PPTA gene was established during evolution of vertebrates. The only Ci-TK receptor, Ci-TK-R, was equivalently activated by Ci-TK-I, SP, and neurokinin A at physiological concentrations, whereas Ci-TK-II showed 100-fold less potent activity, indicating that the ligand selectivity of Ci-TK-R is distinct from those of vertebrate TK receptors. Ci-TK-I, like SP, also elicited the typical contraction on the guinea pig ileum. The Ci-TK gene was expressed in neurons of the brain ganglion, small cells in the intestine, and the zone 7 in the endostyle, which corresponds to the vertebrate thyroid gland. Furthermore, the Ci-TK-R mRNA was distributed in these three tissues plus the gonad. These results showed that Ci-TKs play major roles in sexual behavior and feeding in protochordates as brain/gut peptides and endocrine/paracrine molecules. Taken together, our data revealed the biochemical and structural origins of vertebrate TKs and their receptors.

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“…A more recent approach, taking profit of the chemical methods of analysis, firstly investigates the molecular structure of the hormone (usually by analogy) and then determines its function (Lafont, 2000). It is presumed that many peptide hormones have been conserved during evolution with function being less conserved than structure (Ebberink et al, 1989;Satake et al, 1999), a fact also apparent within vertebrate hormones. Various tissues may possess receptors for a given hormone and, therefore, this hormone will elicit different responses.…”

Section: Introductionmentioning

confidence: 99%

The kind of AKH-mobilized energy substrates in insects can be predicted without a knowledge of the hormone structure

Socha¹,

Kodrı́k²,

Šimek³

et al. 2004

Eur. J. Entomol.

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Abstract. The aim of this study was to show that the kind of AKH-mobilized energy substrates in insects can be predicted on the basis of the results obtained with the application of heterologous, i.e. inter-species, AKHs. Four different AKHs, the Locmi-AKH-I inducing hyperlipaemia and hyperglycaemia in Locusta migratoria, Tenmo-HrTH inducing hyperglycaemia in Tenebrio molitor, and Pyrap-AKH and Peram-CAH-II inducing hyperlipaemia in Pyrrhocoris apterus were used, firstly in conspecific tests, secondly in all possible species-AKH combinations, and finally in individual applications on the test species, the cotton bug Dysdercus cingulatus. Since each of the AKHs induced hyperlipaemia in D. cingulatus adults, we predicted that lipids are the only energy substrates which are mobilized in this species by its native AKH. The accuracy of this prediction was subsequently confirmed by the structural identification of the native D. cingulatus AKH and conspecific application tests. The proposed methodical approach can serve as a suitable monitoring system for determination of the kind of energy substrates mobilized by native insect AKHs until the structure of the hormone is identified.

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Evidence for Conservation of the Vasopressin/Oxytocin Superfamily in Annelida

Cited by 77 publications

References 42 publications

Distribution of oxytocin-like and vasopressin-like immunoreactivities within the central nervous system of the cuttlefish, Sepia officinalis

Distribution of oxytocin-like and vasopressin-like immunoreactivities within the central nervous system of the cuttlefish, Sepia officinalis

Tachykinin and Tachykinin Receptor of an Ascidian, Ciona intestinalis

The kind of AKH-mobilized energy substrates in insects can be predicted without a knowledge of the hormone structure

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