Evidence for continuing neuropsychological impairments in depression

Weiland-Fiedler, Petra; Erickson, Kristine; Waldeck, Tracy; Luckenbaugh, David A.; Pike, Daniel G.; Bonne, Omer; Charney, Dennis S.; Neumeister, Alexander

doi:10.1016/j.jad.2003.10.009

Cited by 268 publications

(176 citation statements)

References 29 publications

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“…Moreover, we considered evidence that TMS treatment applied to the DLPFC should affect not only mood regulation but also the memory-related symptoms. Several studies showed how memory functions are affected in depression, specifically WM [56] and the encoding and retrieval of episodic memory [57] . Also, in anxiety disorders these memory processes seem to be deficient [58] .…”

Section: Contrasting Data That Emerged In Subsequent Years Ledmentioning

confidence: 99%

Dorsolateral prefrontal cortex, working memory and episodic memory processes: insight through transcranial magnetic stimulation techniques

Balconi

2013

Neurosci. Bull.

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The ability to recall and recognize facts we experienced in the past is based on a complex mechanism in which several cerebral regions are implicated. Neuroimaging and lesion studies agree in identifying the frontal lobe as a crucial structure for memory processes, and in particular for working memory and episodic memory and their relationships. Furthermore, with the introduction of transcranial magnetic stimulation (TMS) a new way was proposed to investigate the relationships between brain correlates, memory functions and behavior. The aim of this review is to present the main findings that have emerged from experiments which used the TMS technique for memory analysis. They mainly focused on the role of the dorsolateral prefrontal cortex in memory process. Furthermore, we present state-of-the-art evidence supporting a possible use of TMS in the clinic. Specifically we focus on the treatment of memory deficits in depression and anxiety disorders.

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Section: Contrasting Data That Emerged In Subsequent Years Ledmentioning

confidence: 99%

Dorsolateral prefrontal cortex, working memory and episodic memory processes: insight through transcranial magnetic stimulation techniques

Balconi

2013

Neurosci. Bull.

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“…The working memory performance of unmedicated outpatients with major depression was significantly diminished compared to that of normal people [11], demonstrating not only that depressive patients are emotionally impaired but also that defects in working memory and other cognitive functions are concomitant [5,12,13] and manifest as enhanced memory of mood-congruent negative material and diminished memory of mood-incongruent positive material; this is referred to as the mood-congruent memory effect. The moodcongruent working memory study on subjects in a natural emotional state (depressive patients) and subjects in an induced depressive emotional state by Kwiatkowski and Parkinson [14] showed that only depressive patients manifested a mood-congruent memory effect.…”

Section: Introductionmentioning

confidence: 99%

Emotional Experience and the Mood-Congruent Working Memory Effect in First-Onset and Untreated Depressive Disorder Patients

Li¹,

Lu²

2016

J Psychiatry

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Journal of Psychiatry AbstractUsing an improved Sternberg working memory paradigm and affective pictures of different valences, this study investigates the emotional experience capability of 22 first-onset and untreated major depressive disorder patients (MDD) compared with the matching 22 healthy control participants (HC) and whether there is a moodcongruent working memory effect. We employed a general linear model analysis of variance (ANOVA) with two-factor repeated measures analysis on the emotional experience capability (pupil diameter changes) and the working memory performance (accuracy). The results show that the pupil diameter changes of positive emotions are significantly greater in MDD than those in HC (p<0.001), and the pupil diameter changes of negative emotions are not significantly different between two groups (p=0.055), which suggest that MDD have a significantly decrease in the ability to experience pleasure (anhedonia). In addition, the results only present that the working memory performances of negative emotions are significantly greater in MDD than those of positive emotions (p<0.05), which indicates that there is a mood-congruent memory effect. Moreover, in MDD, a positive correlation is found between the pupil diameter changes and working memory performances of positive emotions, however there is no correlation between those of negative emotions. Taken together, these results suggest that MDD have a moodcongruent memory effect and anhedonia, and the mood-congruent memory effect may be due to the decreased memory performances of positive emotions (a decrease in the ability to experience pleasure), but not those of negative emotions increased. This study not only illustrates that the core symptoms of depressive patients may be a mood-congruent memory effect and anhedonia but also enriches the connotation of anhedonia as an endophenotype indicator.

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“…The neuropsychological deficit in depressed patients has been observed in measures of attentional functions 3,4 , speed of information processing and motor functioning 5,6,7 , episodic memory 2, 8,9 , work memory 10 , and executive functions 1,7 . Other recent work suggests that MDD may also cause bias in the processing of affective information, abnormal responses to negative feedback, and deficits in decision-making 11 .…”

Section: Introductionmentioning

confidence: 99%

Comorbidity of anxiety disorders in major depressive disorder: A clinical trial to evaluate neuropsychological deficit

et al. 2009

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-Background and objectives:Various clinical aspects of Major Depressive Disorder (MDD) are related to the neuropsychological impairments characteristic of this illness. The aim of this study was to determine the relation between certain clinical variables of MDD -in particular the presence of comorbid anxiety disorders -and the neuropsychological performance of patients with MDD selected for a clinical trial.Methods: Using cluster analyses, we generated two groups of patients: one group with Major Depressive Disorder and a Comorbid Anxiety Disorder (MDDAD), and the other 6 IXCHEL HERRERA-GUZMÁN ET AL.

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Evidence for continuing neuropsychological impairments in depression

Cited by 268 publications

References 29 publications

Dorsolateral prefrontal cortex, working memory and episodic memory processes: insight through transcranial magnetic stimulation techniques

Dorsolateral prefrontal cortex, working memory and episodic memory processes: insight through transcranial magnetic stimulation techniques

Emotional Experience and the Mood-Congruent Working Memory Effect in First-Onset and Untreated Depressive Disorder Patients

Comorbidity of anxiety disorders in major depressive disorder: A clinical trial to evaluate neuropsychological deficit

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