Evidence for Cross-species Influenza A Virus Transmission Within Swine Farms, China: A One Health, Prospective Cohort Study

Ma, Mai‐Juan; Wang, Guolin; Anderson, Benjamin D.; Bi, Zhenqiang; Liu, Bing; Wang, Xianjun; Wang, Chuang-Xin; Chen, Shan-Hui; Qian, Yan-Hua; Song, Shaoxia; Lü, Min; Lednicky, John A.; Zhao, Teng; Wu, Mengna; Cao, Wu‐Chun; Gray, Gregory C.

doi:10.1093/cid/cix823

Cited by 50 publications

(78 citation statements)

References 33 publications

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“…Secondarily, we seek to examine the use of serological and mucosal immunities as biomarkers for protection against SIV infections in humans. Results from participant enrollment and Year 1 of ILI surveillance have been previously reported [7,8]. Here, we augment these results with data from the subsequent 24 months of follow-up.…”

mentioning

confidence: 69%

“…As previously reported [7,8], 299 swine-exposed participants ("exposed") were enrolled at the beginning in March of 2015 at 9 swine CAFOs; 97 small, house-holding swine farms; 6 abattoirs, 1 veterinary station; and 1 animal market in Shandong and Jiangsu provinces in China. We also enrolled 100 nonswine-exposed participants ("unexposed") in these regions in 2015.…”

Section: Data and Sample Collectionmentioning

confidence: 99%

“…We employed influenza A virus molecular detection, microneutralization (MN), and immunoglobin A (IgA) assays, as described in our previous study [7]. To assess the possibility of neutralizing-antibody cross-reactivity against circulating human influenza strains, the same MN assay procedure was performed using sera drawn at 12 and 24 months from a random subset of 105 participants (77 exposed and 28 unexposed).…”

Section: Laboratory Analysesmentioning

confidence: 99%

“…In particular, this is true for influenza A viruses (IAVs). The sustained circulation of IAVs and often poor biosecurity provides great opportunity for swine IAVs to reassort or recombine with avian or human IAVs, which can result in novel progeny-virus zoonotic transmission events [7,8]. Previous such events have underlined the importance of pigs in the generation of novel IAVs, including the pandemic outbreak in 2009 [9].…”

mentioning

confidence: 99%

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High Risk of Influenza Virus Infection Among Swine Workers: Examining a Dynamic Cohort in China

Borkenhagen

Wang

Simmons

et al. 2019

Clinical Infectious Diseases

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Background.China is thought to be a hotspot for zoonotic influenza virus emergence, yet there have been few prospective studies examining the occupational risks of such infections.Methods. We present the first 2 years of data collected from a 5-year, prospective, cohort study of swine-exposed and -unexposed participants at 6 swine farms in China. We conducted serological and virological surveillance to examine evidence for swine influenza A virus infection in humans.Results. Of the 658 participants (521 swine-exposed and 137 swine-unexposed), 207 (31.5%) seroconverted against at least 1 swine influenza virus subtype (swine H1N1 or H3N2). Swine-exposed participants' microneutralization titers, especially those enrolled at confined animal feeding operations (CAFOs), were higher against the swine H1N1 virus than were other participants at 12 and 24 months. Despite elevated titers, among the 187 study subjects for whom we had complete follow-up, participants working at swine CAFOs had significantly greater odds of seroconverting against both the swine H1N1 (odds ratio [OR] 19.16, 95% confidence interval [CI] 3.55-358.65) and swine H3N2 (OR 2.97, 95% CI 1.16-8.01) viruses, compared to unexposed and non-CAFO swine workers with less intense swine exposure.Conclusions. While some of the observed increased risk against swine viruses may have been explained by exposure to human influenza strains, study data suggest that even with elevated preexisting antibodies, swine-exposed workers were at high risk of infection with enzootic swine influenza A viruses.

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confidence: 69%

Section: Data and Sample Collectionmentioning

confidence: 99%

Section: Laboratory Analysesmentioning

confidence: 99%

mentioning

confidence: 99%

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High Risk of Influenza Virus Infection Among Swine Workers: Examining a Dynamic Cohort in China

Borkenhagen

Wang

Simmons

et al. 2019

Clinical Infectious Diseases

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“…In conclusion, SARS-CoV-2 which causes COVID-19 is continuing to cause global fears, There is an urgent need for the implementation of multidisciplinary One Health to address the current complex health challenges at the human-animal-environment interface [42,43] One Health approaches in China have recently been described [49][50][51][52]. However, the implementation of One Health policies in China is challenged by several barriers [48,51].…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

From SARS to COVID-19: A previously unknown SARS- related coronavirus (SARS-CoV-2) of pandemic potential infecting humans – Call for a One Health approach

2020

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The concept of one health applied to the problem of zoonotic diseases

Shaheen

2022

Reviews in Medical Virology

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Zoonotic diseases are a burden on healthcare systems globally, particularly underdeveloped nations. Numerous vertebrate animals (e.g., birds, mammals and reptiles) serve as amplifier hosts or reservoirs for viral zoonoses. The spread of zoonotic disease is associated with environmental factors, climate change, animal health as well as other human activities including globalization, urbanization and travel. Diseases at the human-animal environment interface (e.g., zoonotic diseases, vector-borne diseases, food/water borne diseases) continue to pose risk to animals and humans with a great significant mortality and morbidity. It is estimated that of 1400 infectious diseases known to affect humans, 60% of them are of animal origin.In addition, 75% of the emerging infectious diseases have a zoonotic nature, worldwide. The one health concept plays an important role in the control and prevention of zoonoses by integrating animal, human, and environmental health through collaboration and communication among osteopaths, wildlife, physicians, veterinarians professionals, public health and environmental experts, nurses, dentists, physicists, biomedical engineers, plant pathologists, biochemists, and others.

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Evidence for Cross-species Influenza A Virus Transmission Within Swine Farms, China: A One Health, Prospective Cohort Study

Cited by 50 publications

References 33 publications

High Risk of Influenza Virus Infection Among Swine Workers: Examining a Dynamic Cohort in China

High Risk of Influenza Virus Infection Among Swine Workers: Examining a Dynamic Cohort in China

From SARS to COVID-19: A previously unknown SARS- related coronavirus (SARS-CoV-2) of pandemic potential infecting humans – Call for a One Health approach

The concept of one health applied to the problem of zoonotic diseases

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