Evidence for Cytokine Mediation of Disease Expression in Adults Experimentally Infected with Influenza A Virus

Skoner, David P.; Gentile, Deborah A.; Patel, A.; Doyle, William J.

doi:10.1086/314823

Cited by 141 publications

(102 citation statements)

References 26 publications

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“…However, there is still uncertainty regarding the implications of cytokines in symptoms of common cold. For example, while some studies demonstrate an increase in IL-8 during early infection, other studies have shown to peak around day 4-6 (Hayden et al, 1998;Skoner et al, 1999).…”

Section: Resultsmentioning

confidence: 99%

An open label, randomized, multicenter, comparative, three arm Phase II clinical study to evaluate the safety and efficacy of mixture of five species of Ocimum in subjects with acute common cold

Shelke¹,

Pawar²,

Tripathi³

et al. 2016

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Ba sil and its variou s species are known to ha ve an effect on common cold and possess immunomodulatory properties. This paper describes a clinical trial of a herbal formulation, Panchtulasi drops in acute common cold; the formulation consists of essential oils of five species of ocimum, namely; Ocimum sanctum Linn., Ocimum basilicum Linn., Ocimum gratissimum Linn., Ocimum citriodorum Linn. and Ocimum canum Linn.This was an open label, three arm Phase II study to determine the safety and effica cy of Panchatulasi drops in patients with acute common cold. The primary endpoint was reduction in symptoms of cold and number of days of illness. This was assessed using SF-8 and WURSS21 questionnaires. The secondary endpoint was changes in serum interleukin-8 and neutrophil count. The study duration was 8 days with telephonic follow-up on 10 th day. A total of 60 patients were randomized to treatment, placebo and a control (standard medication) in a radio of 2:1:1.The symptom severity, quality of life and number of days of illness measured by questionnaire was significantly reduced in the treatment arm between baseline and day 4 (p<0.05). The physical component score and overall health score of the SF-8 questionnaire also improved considerably in the treatment arm compared to placebo and control arms between baseline and day 4. However, mental component score did not improve significantly until day 6. Concentration of IL-8 did not show any statistically significant change in any of the study arms due to high variability. Neutrophil count, on the other hand, decreased in the treatment arm (p=0.0153) compared to placebo and control arms where it increased. Panchatulasi drops is an effective herbal remedy for common cold and can be used as an alternative to current treatments. There was a significant reduction in days of illness, severity of symptoms, and improvement in quality of life compared to placebo and control groups.

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Section: Resultsmentioning

confidence: 99%

An open label, randomized, multicenter, comparative, three arm Phase II clinical study to evaluate the safety and efficacy of mixture of five species of Ocimum in subjects with acute common cold

Shelke¹,

Pawar²,

Tripathi³

et al. 2016

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“…27 A wide range of cytokines and chemokines are produced in the human upper and lower respiratory tract in response to influenza infection, including interleukin-6 (IL-6), IL-8, IL-10, tumor necrosis factor-␣ (TNF-␣), interferon-␣, interferon-␥, macrophage inhibitory protein-␣, macrophage inhibitory protein-1␤, and macrophage chemotactic protein-1. [28][29][30][31] Moreover, the proinflammatory cytokines, IL-6 and TNF-␣, are found in serum and plasma after experimental influenza infection in humans. 31 Therefore, circulating cytokines and chemokines, together with bacterial endotoxin, may contribute to hepatic damage in the absence of hepatic seeding of the virus.…”

Section: Mechanism Of Hepatic Damagementioning

confidence: 99%

Influenza Infection in Patients Before and After Liver Transplantation

Duchini¹

2000

Liver Transplantation

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Infection with influenza virus poses specific problems in pediatric and adult liver transplant recipients, both before and after liver transplantation. These include a higher rate of pulmonary and extrapulmonary complications, development of rejection with graft dysfunction, prolonged shedding of influenza virus, and increased drug-resistance. Hepatic decompensation may occur during influenza infection in patients with cirrhosis. Current prophylaxis includes yearly vaccination with trivalent inactivated vaccine. Appropriate diagnosis and prompt treatment of any upper respiratory infections are indicated in these patients. In this review, we describe a case of influenza viral pneumonia in an adult liver transplant recipient, review basic and clinical aspects of influenza infection in this patient population, and discuss current modes of prevention and treatment in detail. (Liver Transpl 2000;6: 531-542.)

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“…Levels of IL-8 and IL-6 are increased in airway secretions from individuals with respiratory viral infection (14,18,31). Furthermore, the kinetics and magnitude of IL-8 and IL-6 production correlate with respiratory symptoms in influenza infection (18,31), thus underlining the prominent role of these mediators in virus-induced pathophysiology.…”

mentioning

confidence: 96%

Exaggerated IL-8 and IL-6 responses to TNF-α by parainfluenza virus type 4-infected NCI-H292 cells

Roger¹,

Bresser²,

Snoek³

et al. 2004

American Journal of Physiology-Lung Cellular and Molecular Phys

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Respiratory viruses induce and potentiate airway inflammation, which is related to the induction of proinflammatory mediators such as interleukin (IL)-8 and IL-6. Here we report on mechanisms implicated in IL-8 and IL-6 production by airway epithelium-like NCI-H292 cells exposed to parainfluenza virus type 4a (PIV-4). PIV-4 readily infected NCI-H292 cells as reflected by intracellular PIV-4 antigen expression. PIV-4 infection triggered a biphasic IL-8 and IL-6 mRNA response. Transient transfection with truncated and mutated promoter constructs identified NF-κB and activator protein (AP)-1, and CCAAT-enhancer binding protein (C/EBP) as the relevant transcription factors for PIV-4-induced IL-8 and IL-6 gene transcription, respectively. An increase of DNA-binding activities for NF-κB and C/EBP paralleled the induction of the first and second IL-8 and IL-6 mRNA peaks, whereas the onset of AP-1 paralleled the first IL-8 mRNA peak only. The second mRNA peak, apparently dependent on viral replication, coincided also with a marked reduction of IL-8 and IL-6 mRNA degradation. Importantly, cells at the time of the reduced mRNA degradation displayed an exaggerated IL-8 and IL-6 protein production to a secondary stimulus, as exemplified by steeper dose-response curves to TNF-α. Thus PIV-4 infection enhances epithelial IL-8 and IL-6 production by transcriptional and posttranscriptional mechanisms. The previously unrecognized phase of reduced IL-8 and IL-6 mRNA degradation and the concurrent amplified epithelial IL-8 and IL-6 responses may play an important role in virus-induced potentiation of airway inflammation.

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Evidence for Cytokine Mediation of Disease Expression in Adults Experimentally Infected with Influenza A Virus

Cited by 141 publications

References 26 publications

An open label, randomized, multicenter, comparative, three arm Phase II clinical study to evaluate the safety and efficacy of mixture of five species of Ocimum in subjects with acute common cold

An open label, randomized, multicenter, comparative, three arm Phase II clinical study to evaluate the safety and efficacy of mixture of five species of Ocimum in subjects with acute common cold

Influenza Infection in Patients Before and After Liver Transplantation

Exaggerated IL-8 and IL-6 responses to TNF-α by parainfluenza virus type 4-infected NCI-H292 cells

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