Evidence for Endocrine Disruption in Perch (Perca fluviatilis) and Roach (Rutilus rutilus) in a Remote Swedish Lake in the Vicinity of a Public Refuse Dump

Noaksson, Erik; Tjärnlund, Ulla; Bosveld, A.T.C.; Balk, Lennart

doi:10.1006/taap.2001.9194

Cited by 92 publications

(48 citation statements)

References 53 publications

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“…In many of these cases, the etiology of gonadal malformation is not known. It is well established, however, that gonad morphology and differentiation in fish is susceptible to a variety of environmental factors such as temperature (Patino et al 1996, Kitano et al 1999, Goto et al 2000, Baroiller & Guiguen 2001, parasites (Wicklund & Bylund 1994) or chemical substances, both compounds with endocrine activity (Jobling et al 1998, Rodgers-Gray et al 2000, Noaksson et al 2001, Matthiessen et al 2002, Vethaak et al 2002 and compounds with other modes of toxic action (Johnson et al 1998, Kime 1998. To advance our currently still fragmentary knowledge of gonadal malformations and their etiology in wild fish populations, a careful documentation of case studies on gonad aberrations in wild fish stocks is an important requirement (Blazer 2002).…”

Section: Introductionmentioning

confidence: 99%

Frequent and unexplained gonadal abnormalities in whitefish (central alpine Coregonus sp.) from an alpine oligotrophic lake in Switzerland

Bernet¹,

Wahli²,

Kueng³

et al. 2004

Dis. Aquat. Org.

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Section: Introductionmentioning

confidence: 99%

Frequent and unexplained gonadal abnormalities in whitefish (central alpine Coregonus sp.) from an alpine oligotrophic lake in Switzerland

Bernet¹,

Wahli²,

Kueng³

et al. 2004

Dis. Aquat. Org.

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“…Nath & Kumar 1990, Crump & Trudeau 2009, Segner 2011 or with sex reversal resulting from hormone therapies (e.g. Kipfer et al 2009 (and intersex) gonad tissues (Jobling et al 1998, van Aerle et al 2001, Noaksson et al 2001, Kavanagh et al 2004, Hanson 2009). Hermaphroditic histological changes in the ovaries have also been reported in northern pike (Dominguez et al 1989, Vine et al 2005.…”

Section: Discussionmentioning

confidence: 99%

“…Gonad alterations may be caused by endocrine disruptors (ED) (Jobling & Tyler 2003) originating from wastewater and sludge treatment processes, which may cause disturbances in aquatic ecosystems (Birkett & Lester 2003). EDs have been identified as the direct cause of reproductive abnormalities in fishes (van Aerle et al 2001, Noaksson et al 2001, Bernet et al 2004, Kirby et al 2004, Hliwa et al 2011. ED are usually chemical compounds which directly 53 Fig.…”

Section: Discussionmentioning

confidence: 99%

Ovarian alterations in wild northern pike Esox lucius females

et al. 2013

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The aim of the present study was to analyse the occurrence of macroscopically visible ovary alterations in 2 populations of northern pike Esox lucius L. originating from lakes in the Mazurian Lake District (NE Poland). The alterations were characterised by ovary tissue that was morphologically malformed, in part or in whole, and contained immature oocytes, i.e. trophoplastic or previtellogenic oocytes instead of vitellogenic oocytes. These alterations were found only in the ovaries, and no morphological alterations of the testes were noted. Macroscopic and histological analyses were carried out in order to classify the observed alterations in the ovaries. Three types of alterations were identified in which morphological malformations as well as histological investigation of the ovaries were considered. An analysis of the size and age of the fish in relation to the occurrence of alterations as well as of the macroscopic and histological nature of the alteration types was made. The data obtained revealed no lake or age dependency of the observed alterations. Based on the results obtained, we suggest that the presence of endocrine disruptors in the environment or/and genetic factors could be responsible for these kinds of gonad anomalies. However, our results did not allow us to determine the aetiology of the alterations. KEY WORDS: Northern pike · Ovary alterations · Endocrine disruptors · Reproduction · Recruitment successResale or republication not permitted without written consent of the publisher

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“…For this purpose, candidate measures can be selected according to their specificity, mechanistic basis, threshold values, effect sizes, and effect quantification. The advantage of using a broader set of mechanistically based effect measures is the capability to differentiate between the impact of EACs and other toxicants, since EACs are often found at complexly contaminated sites with many chemicals showing different modes of action being present [52,53]. Multiple response measurements may be facilitated by recently developed techniques such as gene arrays.…”

Section: Integrated Chemical-biological Monitoringmentioning

confidence: 99%

Need for establishing integrated programs to monitor endocrine active compounds

Segner¹

2003

Pure and Applied Chemistry

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Environmental monitoring programs on endocrine active compounds (EACs) have been used to document the level of exposure and to assess the possible association to the occurrence of developmental and reproductive disorders in wildlife. The establishment of causal links between exposure and effect data, however, was found to be difficult due to, for example, the presence of confounding factors or limited understanding of EAC mechanisms and interactions, but also because of conceptual and methodological limitations of current monitoring strategies. In order to provide plausibility of an EAC etiology for a developmental or reproductive alteration in a wildlife population, integrated monitoring programs are needed that will use a combination of complementary approaches: methods for a targeted search for suspected EACs in an environmental mixture, analysis of internal EAC doses instead of external EAC concentrations, utilization of mechanism-based endpoints in bioanalytical and effect monitoring, investigation of the basic biology and physiology of wildlife sentinel species, laboratory replication of field effects, as well as consideration of epidemiological and weight-of-evidence criteria in the design and data evaluation of monitoring programs.

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Evidence for Endocrine Disruption in Perch (Perca fluviatilis) and Roach (Rutilus rutilus) in a Remote Swedish Lake in the Vicinity of a Public Refuse Dump

Cited by 92 publications

References 53 publications

Frequent and unexplained gonadal abnormalities in whitefish (central alpine Coregonus sp.) from an alpine oligotrophic lake in Switzerland

Frequent and unexplained gonadal abnormalities in whitefish (central alpine Coregonus sp.) from an alpine oligotrophic lake in Switzerland

Ovarian alterations in wild northern pike Esox lucius females

Need for establishing integrated programs to monitor endocrine active compounds

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