Evidence for existence of insulin-like factor 3 (INSL3) hormone-receptor system in the ovarian corpus luteum and extra-ovarian reproductive organs during pregnancy in goats

Pitia, Ali Mohammed; Minagawa, Itaru; Abe, Yasuyuki; Kizaki, Keiichiro; Hamano, Koh‐ichi; Sasada, Hiroshi; Hashizume, Kazuyoshi; Kohsaka, Tetsuya

doi:10.1007/s00441-021-03410-1

Cited by 6 publications

(8 citation statements)

References 85 publications

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“…The expression of INSL3 mRNA has been reported in the bovine corpus luteum during the estrus cycle [ 21 , 50 ], and the peptide has been detected in pregnant caprines [ 51 ]. In the current work, INSL3 content was measured in the bovine corpus luteum during the estrus cycle.…”

Section: Discussionmentioning

confidence: 99%

Quantitative analyses of insulin-like peptide 3 and sex steroid hormones in dominant follicles and corpora lutea during the estrus cycle and in follicular cysts in beef heifers

WIMALARATHNE¹,

WAKO²,

Kawate³

2022

Journal of Reproduction and Development

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Insulin-like peptide 3 (INSL3) and sex steroids were measured in bovine dominant follicles and corpora lutea during the estrus cycle and in follicular cysts. Paired ovaries from beef heifers (n = 47) were classified, by their morphological features, either into four stages of the estrus cycle (Day 1 = day of ovulation, Day 20 = day of estrus) as Stage I (Days 1–4; n = 8), Stage II (Days 5–10; n = 10), Stage III (Days 11–17; n = 8), and Stage IV (Days 18–20; n = 11) or follicular cystic (n = 10). Cysts (n = 15) were subdivided into estrogen-active (n = 7) and estrogen-inactive (n = 8) cysts. INSL3, testosterone, and estradiol-17β concentrations in the dominant follicular fluid of Stage IV were higher than those in Stages II and III (P < 0.05). INSL3 concentrations in the cystic fluid were similar to those in dominant follicles at Stage IV, whereas testosterone and estradiol-17β concentrations were lower in cysts (P < 0.05). INSL3 content per estrogen-inactive cyst was higher than that of Stage IV (P < 0.05). INSL3 and progesterone concentrations in luteal tissue and contents per corpus luteum were higher in Stages II and III (P < 0.05). In conclusion, INSL3 secretion in bovine dominant follicles increased with maturation. Follicular cysts may retain the production of INSL3 during their formation but tend to lose the capacity for testosterone secretion. Estrogen-inactive cysts subjected to advanced atresia may accumulate more INSL3. INSL3 production in bovine corpora lutea is enhanced during maturation.

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Section: Discussionmentioning

confidence: 99%

Quantitative analyses of insulin-like peptide 3 and sex steroid hormones in dominant follicles and corpora lutea during the estrus cycle and in follicular cysts in beef heifers

WIMALARATHNE¹,

WAKO²,

Kawate³

2022

Journal of Reproduction and Development

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“…The exclusive expression of the INSL3 peptide in testicular Leydig cells has been reported in mice, 23 stallions, 21 bulls, 24 , 25 boars, 26 and goats. 27 The INSL3 mRNA or peptide is also expressed in the ovarian follicular theca interna cells in cattle, 19 , 25 , 28 dogs, 29 goats, 30 and in the luteal cells in humans, 31 cattle, 19 , 24 mice, 23 , 30 goats, 30 rats, 30 and pigs. 30 …”

Section: Insl3 Structure Expression Receptor and Rolesmentioning

confidence: 99%

Section: Insl3 Structure Expression Receptor and Rolesmentioning

confidence: 99%

“…27 The INSL3 mRNA or peptide is also expressed in the ovarian follicular theca interna cells in cattle, 19,25,28 dogs, 29 goats, 30 and in the luteal cells in humans, 31 cattle, 19,24 mice, 23,30 goats, 30 rats, 30 and pigs. 30 Quantitative analyses of INSL3 mRNA and peptide expressions in gonads have been reported in a few studies. Satchell et al 25 suggested that INSL3 mRNA in bovine follicular granulosa cells increased during follicular development, measured by real-time PCR.…”

Section: Expressioningonadsmentioning

confidence: 99%

“… 56 In bovine female reproductive tissues, RXFP2 mRNA was detected in ovarian follicular theca cells, oocyte corpus luteum, and uterine myometrial cells 25,57,58 . In goats, RXFP2 was expressed in (1) luteal cells of corpus luteum, (2) follicular theca cells of ovaries, (3) tubuloalveolar and ductal epithelium of mammary glands, (4) luminal and glandular epithelium, stroma cells, and smooth muscle layer of the uterus and cervix, and (5) chorionic epithelium and syncytium of the placenta 30 …”

Section: Insl3 Structure Expression Receptor and Rolesmentioning

confidence: 99%

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Insulin‐like peptide 3 in domestic animals with normal and abnormal reproductive functions, in comparison to rodents and humans

Kawate

2022

Reprod Medicine & Biology

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Background Insulin‐like peptide 3 (INSL3) is a circulating hormone secreted from only testis and ovaries in mammals. Findings on INSL3 have been gathered from subjects with normal and abnormal reproductive statuses, especially rodents and humans. However, little to no review articles focusing on INSL3 in domestic animals exist. Methods The author reviewed the past and recent literature regarding the structure, expression, roles of INSL3 in the reproductive organs, and its circulation under normal and aberrant reproductive conditions in domestic animals in comparison with rodents and humans. Main findings As with humans and rodents, blood INSL3 concentrations rise around puberty in normal male domestic animals and are associated with testicular size. INSL3 levels are acutely upregulated by luteinizing hormone (LH), and the increase is smaller than that of testosterone in male ruminants, whereas the acute regulation of INSL3 by LH does not occur in human men. Dogs with cryptorchidism and bulls with abnormal semen have lowered INSL3 levels. Conclusion The findings regarding INSL3 secretions in male domestic animals with normal and aberrant reproductive functions illustrate similar or dissimilar points to humans and rodents. Data on blood INSL3 levels in normal and abnormal female domestic species are still limited and require further investigation.

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Identification and functional analysis of insulin-like 3 during gonad development in the hermaphroditic orange-spotted grouper, Epinephelus coioides

Zhang,

Wang,

Zhang

et al. 2024

Aquaculture

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Evidence for existence of insulin-like factor 3 (INSL3) hormone-receptor system in the ovarian corpus luteum and extra-ovarian reproductive organs during pregnancy in goats

Cited by 6 publications

References 85 publications

Quantitative analyses of insulin-like peptide 3 and sex steroid hormones in dominant follicles and corpora lutea during the estrus cycle and in follicular cysts in beef heifers

Quantitative analyses of insulin-like peptide 3 and sex steroid hormones in dominant follicles and corpora lutea during the estrus cycle and in follicular cysts in beef heifers

Insulin‐like peptide 3 in domestic animals with normal and abnormal reproductive functions, in comparison to rodents and humans

Identification and functional analysis of insulin-like 3 during gonad development in the hermaphroditic orange-spotted grouper, Epinephelus coioides

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