Evidence for extrathymic generation of intermediate T cell receptor cells in the liver revealed in thymectomized, irradiated mice subjected to bone marrow transplantation.

Sato, Kazunari; Ohtsuka, Kazuo; Hasegawa, Katsuhiko; Yamagiwa, Satoshi; Watanabe, Hirotaka; Asakura, Hitoshi; Abo, Toru

doi:10.1084/jem.182.3.759

Cited by 190 publications

(156 citation statements)

References 36 publications

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“…CD3 is expressed with intermediate intensity by liver-derived extrathymic T cells [24], and extrathymic T cells and NK cells constitutively express CD122 (IL-2R b chain) but not p<0.0003 to any other groups) were transferred into 8-Gyirradiated K5-mOVA mice. Cells were purified from LN and spleen of K5-mOVA mice.…”

Section: Discussionmentioning

confidence: 99%

Prevention of toxic epidermal necrolysis by regulatory T cells

et al. 2005

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Section: Discussionmentioning

confidence: 99%

Prevention of toxic epidermal necrolysis by regulatory T cells

et al. 2005

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“…Extrathymic pathways of T cell differentiation exist in the intestine and liver (Sato et al 1995), where T cell populations may arise from their own preexisting precursor cells rather than thymus (Sugahara et al 1999). Extrathymic T cells are also present in the uterus and exocrine glands, for example, salivary gland (Abo 2001 (int) , and presence of self-reactive clones (Abo 1993;Ohteki et al 1992).…”

Section: Liver Involvement In Extrathymic T Cell Productionmentioning

confidence: 99%

Immune Functioning in Non lymphoid Organs: The Liver

Parker

Picut

2011

Toxicol Pathol

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The liver is the primary hematopoietic organ of the mammalian body during the fetal stage. The postnatal liver retains immunologically important functions and contains a substantial population of immunologically active cells, including T and B lymphocytes, Kupffer cells, liver-adapted natural killer (NK) cells (pit cells), natural killer cells expressing T cell receptor (NKT cells), stellate cells, and dendritic cells. The liver is the major site of production of the acute phase proteins that are associated with acute inflammatory reactions. Kupffer cells have an important role in the nonspecific phagocytosis that comprises a major component of the barrier to invasion of pathogenic organisms from the intestine. Hepatic NK and NKT cells are important in the nonspecific cell killing that is important in resistance to tumor cell invasion. The liver has a major role in deletion of activated T cells and induction of tolerance to ingested and self-antigens. Disposal of waste molecules generated through inflammatory, immunologic, or general homeostatic processes is accomplished via the action of specific endocytic receptors on sinusoidal endothelial cells of the liver. Age-related changes in sinusoids (pseudocapillarization), autophagy, and functions of various hepatic cell populations result in substantial alterations in many of these immunologically important functions.

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“…In mice, two anatomic sites of extrathymic T cell development have been identified, the liver and intestinal cryptopatches [30,31]. To determine where extrathymic T cell differentiation takes place in axolotl, RT-PCR/Southern blotting or RT-PCR experiments were performed on 3-, 6-, 15-and 36-month-old axolotl intestinal RNA using primers and specific probes corresponding to enzymes (TdT and RAG1) or transcription factors (Ikaros, Helios, GATA3) involved in T cell development (Fig.…”

Section: The Intestine As An Extrathymic Site Of T Cell Differentiationmentioning

confidence: 99%

Highly restricted diversity of TCR delta chains of the amphibian Mexican axolotl (Ambystomamexicanum) in peripheral tissues

et al. 2007

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epithelial surfaces to exert both protective and regulatory roles in response to infections. We have previously characterized the Mexican axolotl (Ambystoma mexicanum) T cell receptor delta (TRD) chain. In this study, TRD repertoires in spleen, liver, intestine and skin from larvae, pre-adult and adult axolotls were examined and compared to the thymic TRD repertoire. A TRDV transcript without N/D diversity, TRDV1S1-TRDJ1, dominates the TRD repertoires until sexual maturation. In adult tissues, this canonical transcript is replaced by another dominant TRDV1S1-TRDJ1 transcript. In the thymus, these two transcripts are detected early in development. Our results suggest that cd T cells that express the canonical TRDV1S1-TRDJ1 transcript emerge from the thymus and colonize the peripheral tissues, where they are selectively expanded by recurrent ligands. This particular situation is probably related to the neotenic state and the slow development of the axolotl. In thymectomized axolotls, TRD repertoires appear different from those of normal axolotls, suggesting that extrathymic cd T cell differentiation could occur. Gene expression analysis showed the importance of the gut in T cell development.

show abstract

Evidence for extrathymic generation of intermediate T cell receptor cells in the liver revealed in thymectomized, irradiated mice subjected to bone marrow transplantation.

Cited by 190 publications

References 36 publications

Prevention of toxic epidermal necrolysis by regulatory T cells

Prevention of toxic epidermal necrolysis by regulatory T cells

Immune Functioning in Non lymphoid Organs: The Liver

Highly restricted diversity of TCR delta chains of the amphibian Mexican axolotl (Ambystomamexicanum) in peripheral tissues

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