Evidence for field change in oral cancer based on cytokeratin expression

“…4J), a marker for head-andneck epithelia but not normal or hyperplastic epidermis (Bloor et al 1998), and positive staining for K18 (Fig. 4K), a marker for late-stage SCC (Ogden et al 1993). In metastatic lesions, keratin pearls were evident (Fig.…”

Section: Head-and-neck Epithelia With Tgf␤rii Deletion Together With mentioning

confidence: 96%

Loss of transforming growth factor-β type II receptor promotes metastatic head-and-neck squamous cell carcinoma

Lu¹,

Herrington²,

Reh³

et al. 2006

Genes Dev.

191

223

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The prognosis of head-and-neck squamous cell carcinoma (HNSCC) has not been improved in the past 20 years. Validation of HNSCC biomarkers for targeted therapy has been hindered by a lack of animal models mimicking human HNSCC at both the pathological and molecular levels. Here we report that overexpression of K-ras or H-ras and loss of transforming growth factor-␤ type II receptor (TGF␤RII) are common events in human HNSCC. Activation of either K-ras or H-ras in combination with TGF␤RII deletion from mouse head-and-neck epithelia caused HNSCC with complete penetrance, some of which progressed to metastases. These tumors displayed pathology indistinguishable from human HNSCCs and exhibited multiple molecular alterations commonly found in human HNSCCs. Additionally, elevated endogenous TGF␤1 in these lesions contributed to inflammation and angiogenesis. Our data suggest that targeting common oncogenic pathways in tumor epithelia together with blocking the effect of TGF␤1 on tumor stroma may provide a novel therapeutic strategy for HNSCC.[Keywords: HNSCC; head-and-neck-specific knockout; metastasis; Ras; TGF␤RII; TGF␤1] Supplemental material is available at http://www.genesdev.org.

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“…This concept of field cancerization is supported by various histological, cytological and molecular evidence in which normal epithelium has been compared with adjacent tumour tissue which demonstrated similar subcellular and biochemical changes [7][8][9]. The histopathological and cytologic diagnosis of oral cancer is based on epithelial dysplastic features which has subjective variation, with wide variation between observers in the subjective evaluation of epithelial dysplasia has and been commented on by several authors [10].…”

Section: Introductionmentioning

confidence: 92%

“…The histopathological and cytologic diagnosis of oral cancer is based on epithelial dysplastic features which has subjective variation, with wide variation between observers in the subjective evaluation of epithelial dysplasia has and been commented on by several authors [10]. Also the molecular methods are very expensive [8]. To overcome unreliability in the subjective examination of these features a more objective approach would be the value which is mainly based on image analysis techniques.…”

Section: Introductionmentioning

confidence: 99%

Histomorphometric Study to Compare Histological Changes Between Oral Squamous Cell Carcinoma and Apparently Normal Adjacent Oral Mucosa

Babji¹,

Kale

Hallikerimath

et al. 2014

Indian J Otolaryngol Head Neck Surg

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Despite the advances in surgery, radiotherapy and chemotherapy the annual death for oral squamous cell carcinoma (OSCC) is rising rapidly. The carcinoma has propensity to develop in a field of cancerization. Clinically may it be apparently normal mucosa (ANM) adjacent to squamous cell carcinoma which harbours certain discrete molecular alteration which ultimately reflects in cellular morphology. Hence the aim of the study is to assess histomorphometric changes in ANM adjacent to OSCC. A prospective study was done on 30 each of histologically diagnosed cases OSCC, ANM at least 1 cm away from OSCC, and normal oral mucosa (NOM). Cellular and nuclear morphometric measurements were assessed on hematoxylin and eosin sections using image analysis software. Statistical analysis was done using analysis of variance test and Tukey's post hoc test. The present study showed significant changes in cellular and nuclear area in superficial and invasive island of OSCC compared to ANM. The basal cells of ANM showed significant decrease in cellular and nuclear areas and nuclear cytoplasmic ratio when compared to NOM. Histomorphometry definitely can differentiate OSCC form ANM and NOM. The basal cells of ANM showed significant alterations in cellular area, nuclear area and nuclear cytoplasmic area when compared to NOM suggesting change in the field and have high risk of malignant transformation. These parameters can be used as indicator of field cancerization.

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Evidence for field change in oral cancer based on cytokeratin expression

Cited by 43 publications

References 19 publications

Cytokeratin alteration in oral leukoplakia and oral squamous cell carcinoma

Cytokeratin alteration in oral leukoplakia and oral squamous cell carcinoma

Loss of transforming growth factor-β type II receptor promotes metastatic head-and-neck squamous cell carcinoma

Histomorphometric Study to Compare Histological Changes Between Oral Squamous Cell Carcinoma and Apparently Normal Adjacent Oral Mucosa

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