Evidence for Gastrointestinal Infection of SARS-CoV-2

Review of the 2019 novel coronavirus (SARS-CoV-2) based on current evidence

“…Based on bioinformatics evidence indicated that digestive tract might be a potential route of SARS-CoV-2 infection [23]. Consistently, SARS-CoV-2 RNA was also dectected in gastrointestinal tissues from COVID-19 patients [24]. Moreover, SARS-CoV-2 was detected in the tears and conjunctival secretions of covid-19 patients [25].…”

“…A case report of the pathological manifestations of a patient with pneumonia showed moderate microvesicular steatosis in his liver tissue [36]. Besides, tissue samples of stomach, duodenum, and rectal mucosa were confirmed positive for SARS-CoV-2 RNA [37] (Figure 2).…”

Alerta: los síntomas gastrointestinales podrían ser una manifestación de la COVID-19

“…25 Of more importance is the fact that a group from China found that in more than 20% of the patients infected with SARS-Cov-2 that had a negative conversion of the viral RNA in the respiratory tract, the viral RNA was still present in the stools. 26 These evidences support a fecaloral transmission of the SARS-CoV-2, which deserves further investigations. 24 Another important issue to highlight is the recent finding reported by Lin et al, of the presence of herpetic-type erosions and ulcers localized in the esophagus as source of GI bleeding in one of their patients, with detection of SARS-Co-V-2 RNA in these erosions.…”

Prolonged viral shedding in feces of pediatric patients with coronavirus disease 2019

“…Xiao and colleagues demonstrated that about a quarter of COVID-19 patients had SARS-CoV-2 RNA detectable in feces after + MODEL viral clearance in respiratory tract. 27 However, these researchers did not address whether persistent shedding of SARS-CoV-2 was more common in certain age group than the others (patient's ages ranged from 10 months to 78 years in this study). Therefore, patients who are discharged on the basis of current guidelines depending on respiratory tract test might be a potential source of viral transmission and follow-up of recovered patients during convalescent phase is advisable.…”