Evidence for growth inhibition by platinum electrodes at low current levels

Mortensen, Børge Thing; Bojsen, J.

doi:10.1016/0141-5425(82)90069-3

Cited by 16 publications

(9 citation statements)

References 9 publications

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“…38 7. No effect of the nature of metallic electrodes was found on the tumor destruction, 7,38,39 e.g., silver and tungsten electrodes gave results similar to platinum: 7 this also means that a slight anodic dissolution of platinum that might occur during the ECT experiment is not responsible for the necrosis of the tumor. 7 8.…”

Section: Phenomenology Of Ectmentioning

confidence: 58%

“…This work of Miklav i and coworkers also confirms the lack of any role of the nature of electrodes (e.g., Pt, Ir, Au, Ti) or hyperthermia in the destruction of the tumor tissue, mentioned above from the work of other investigators. 7,38,39 9. Many workers report that fast-growing regions of organisms, i.e., tumors are electrically negative with respective to the surrounding normal tissue.…”

Section: Phenomenology Of Ectmentioning

confidence: 98%

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Phenomenology and Mechanisms of Electrochemical Treatment (ECT) of Tumors

Vijh

Modern Aspects of Electrochemistry

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Section: Phenomenology Of Ectmentioning

confidence: 58%

Section: Phenomenology Of Ectmentioning

confidence: 98%

Phenomenology and Mechanisms of Electrochemical Treatment (ECT) of Tumors

Vijh

Modern Aspects of Electrochemistry

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“…platinum chloride compounds from electrode corrosion dissolve at higher potentials and can inhibit cell growth [45], however at lower potentials and in the presence of serum albumin no platinum dissolution was observed [46]. On the other hand, the platinum corrosion can probably be ruled out in this case, since a similar growth inhibiting effect at low currents was also observed on indium tin oxide electrodes.…”

Section: In Vitro Experimentsmentioning

confidence: 71%

Effects of small pulsed nanocurrents on cell viability in vitro and in vivo: Implications for biomedical electrodes

et al. 2010

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1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 AbstractUsing a custom-built, implantable pulse generator, we studied the effects of small pulsed currents on the viability on rat aortic-derived cells (RAOC) in vitro. The pulsed currents (0.37 A/m 2 ) underwent apoptosis within 24 h as shown by the positive staining for cleaved caspase-3 and classically apoptotic morphology. Based on these findings, we examined the effects of nanocurrents in vivo. The pulse generator was implanted subcutaneously in the rat model. The electrode|tissue interface histology revealed no difference between the active platinum surface and the neighboring control surface, however we found a large difference between electrodes that were functional during the entire experiment and non-active electrodes. These non-active electrodes showed an increase in impedance at higher frequencies 21 days post-implantation, whereas working electrodes retained their impedance value for the entire experiment. These results indicate that applied currents can reduce the impedance of implanted electrodes.

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“…This was probably because the local environment around the electrodes is sterilized during treatment by the cytotoxic electrode products. Platinum salts, leached from the electrodes during treatment may also augment this effect as they are strongly bactericidal even in low concentrations [27,28]. This contributes to the extremely low long-term morbidity associated with electrolysis and suggests that there are unlikely to be any major mid-or long-term complications in the clinical setting.…”

Section: Discussionmentioning

confidence: 93%

A new treatment for unresectable liver tumours: long-term studies of electrolytic lesions in the pig liver

Wemyss‐Holden¹,

ROBERTSON²,

Dennison³

et al. 2000

Clinical Science

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The majority of liver tumours are inoperable and an alternative treatment to surgical resection is urgently needed. Electrolysis has been investigated in a rat model and the procedure is safe, with accurate and predictable effects. The necrosis produced has also been shown to cause destruction of tumour deposits in the rat liver. A similar evaluation in a large animal model was necessary before clinical trials could commence. Using platinum electrodes connected to a d.c. generator, areas of hepatic necrosis were created in the pig liver. Animals were killed at various time points after treatment to assess the extent of healing. Treatment was uneventful and all animals made a full recovery. No animal died from the treatment or had to be killed prematurely. After 2 days of treatment, healing was minimal but at successive time points there was progressive evidence of healing, such that after 4 months, the original electrolytic lesion was greatly reduced in size and the large area of necrosis seen at the early time points was largely replaced by a fibrous scar with only small islands of necrotic tissue. In a large animal model, electrolysis is a safe method for creating areas of hepatic necrosis. The lesions heal with time and are associated with minimal morbidity. The results support a trial of electrolysis in patients with unresectable liver tumours.

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Evidence for growth inhibition by platinum electrodes at low current levels

Cited by 16 publications

References 9 publications

Phenomenology and Mechanisms of Electrochemical Treatment (ECT) of Tumors

Phenomenology and Mechanisms of Electrochemical Treatment (ECT) of Tumors

Effects of small pulsed nanocurrents on cell viability in vitro and in vivo: Implications for biomedical electrodes

A new treatment for unresectable liver tumours: long-term studies of electrolytic lesions in the pig liver

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