Evidence for high incidence of end-stage renal disease in patients after stroke and acute myocardial infarction at age 60 or younger

Iseki, Kunitoshi; Wakugami, Kiyoshi; Maehara, Aiwa; Tozawa, Masahiko; Muratani, Hiromi; Fukiyama, Koshiro

doi:10.1053/ajkd.2001.29219

Cited by 15 publications

(10 citation statements)

References 19 publications

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“…We found that survivors of stroke and acute myocardial infarction had a higher incidence of ESRD than those who had not experienced such events. 67 This was as expected, as these conditions often have risk factors similar to those for ESRD. For example, a high heart rate is a cardiovascular risk factor that is often associated with other risk factors for ESRD.…”

Section: Exercise Habitssupporting

confidence: 77%

Factors influencing the development of end-stage renal disease

Iseki

2005

Clin Exp Nephrol

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Epidemiological evidence is needed to design effective strategies for preventing chronic kidney disease (CKD) and end-stage renal disease (ESRD). Several types of health check are routinely performed in Japan, including the screening of asymptomatic individuals, but the potential benefits of these procedures remain unknown. We evaluated the predictors of ESRD, using community-based mass screening and a dialysis registry. This approach revealed the significance of proteinuria, hypertension, obesity, anemia, and high fasting plasma glucose levels (which indicate diabetes mellitus; DM), for the risk of developing ESRD. Lifestyle-related factors, such as smoking, alcohol consumption, and low levels of exercise, are also associated with these conditions and, in particular, with a high risk of ESRD. Over-nutrition and low levels of exercise can ultimately lead to DM, hypertension, hyperlipidemia, and obesity, and are important risk factors worldwide for cardiovascular diseases, CKD, and ESRD. The early detection and treatment of predictors of ESRD, along with appropriate treatment for CKD, may decrease the incidence of ESRD. In addition, the economic burden caused by the costs of dialysis presents a compelling argument for implementing a cost-effective preventive strategy against ESRD.

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Section: Exercise Habitssupporting

confidence: 77%

Factors influencing the development of end-stage renal disease

Iseki

2005

Clin Exp Nephrol

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“…The true prevalence of chronic nephropathy related to degenerative disorders is probably higher, however, given that all subjects with UCN were >60 and 80% of them were >70; most of them also had concurrent systemic atherosclerosis and hypertension. This clinical picture is similar to the one seen in patients developing end-stage renal disease (ESRD) after stroke and acute myocardial infarction [10]. A tentative explanation might be that the underlying renal disorder in UCN is the same as the one observed by Kasiske in an autopsy study, i.e.…”

Section: Discussionsupporting

confidence: 76%

High chronic nephropathy detection yield in CKD subjects identified by the combination of albuminuria and estimated GFR

Gambaro

Bonfante

Abaterusso

et al. 2011

Nephrology Dialysis Transplantation

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“…Among subjects aged 30 to 59 yr, the observed-expected ratio was 4.1 in men (P Ͻ 0.01) and 5.8 in women (P Ͻ 0.01). Among subjects 60 yr and older, the observed-expected ratio was 0.8 in men and 0.4 in women, and was NS (16).…”

Section: Esrd Development In the Hospital-based Stroke And Ami Registrymentioning

confidence: 82%

The Okinawa Screening Program

Iseki¹

2003

Journal of the American Society of Nephrology

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Abstract. Predictors of ESRD were identified using independent registries of both ESRD patients and the general population in Okinawa, Japan. Besides male gender, we found that the significant predictors of ESRD to be proteinuria, hematuria, and hypertension, especially diastolic BP. Among the laboratory findings, a high serum creatinine level was shown to be a strong predictor of ESRD. The effects of age, obesity, and hypercholesterolemia were insignificant, but this needs to be confirmed in a larger cohort and other registries.The number of ESRD patients requiring chronic dialysis is increasing worldwide. In Japan, a high incidence and prevalence of ESRD has been reported in Okinawa, the island prefecture in the southernmost part of the country (1,2). Since 1971, all chronic dialysis patients treated in Okinawa from the start of therapy have been entered into a registry, and the ESRD trends over the past 30 yr have recently been published (1). For geographic and cultural reasons, ESRD patients in Okinawa tend not to move away (3,4). Therefore, Okinawa provides a good population in which to study the outcomes of ESRD and cardiovascular disease (3,4). Understanding the process of disease progression is necessary in determining strategies for the prevention of ESRD.We are fortunate to have access to independent registries for ESRD patients (5), the general population (6,7), and all hospital-based records of stroke and acute myocardial infarction (AMI) (3) in Okinawa. In this paper, we have identified predictors for ESRD using these registries. Materials and Methods Study DesignData from three independent registries covering the entire area of Okinawa were accessed: the ESRD program (5), the screening program of the Okinawa General Health Maintenance Association (OGHMA) (6 -11), and the hospital-based registry of stroke and AMI (3). The start date of chronic dialysis was used as the date of onset of ESRD in individual patients. The 1983 screening participants and the individuals who had become dialysis patients from April 1983 to March 1994 were identified by using the dialysis registry, which covers the entire geographic area. The identities of these dialysis patients were verified by reviewing their medical charts in the dialysis units. ESRD Patient RegistryAll chronic dialysis patients who survive at least 1 mo on scheduled dialysis are included in the Okinawa Dialysis Study (OKIDS) registry.Patients dying within 1 mo from the start of dialysis are not included in the registry because it cannot be determined whether renal function in these patients has been improving or deteriorating or whether other medical conditions accounted for their rapid demise. Pertinent clinical data were obtained for all new dialysis patients, and important medical events recorded in the files of chronic dialysis patients were noted. Data were obtained under collaboration with physicians in all dialysis units. In 1990, there were 27 dialysis units in Okinawa; by the end of 2000, there were 46: nine in the public sector, 17 in private ...

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Evidence for high incidence of end-stage renal disease in patients after stroke and acute myocardial infarction at age 60 or younger

Cited by 15 publications

References 19 publications

Factors influencing the development of end-stage renal disease

Factors influencing the development of end-stage renal disease

High chronic nephropathy detection yield in CKD subjects identified by the combination of albuminuria and estimated GFR

The Okinawa Screening Program

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