Evidence for hydroxyl radical generation by human Monocytes.

Weiss, Stephen J.; King, Gerald W.; LoBuglio, Albert F.

doi:10.1172/jci108785

Cited by 156 publications

(72 citation statements)

References 18 publications

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“…These data are similar to those obtained in recent spin trapping studies of MDM ( 16,20,22). Yet they contrast conclusions reached in other studies of macrophages, including human AM (45)(46)(47)(48)(49)(50)(51)(52). The reason for the discrepancy among these studies is not totally clear.…”

Section: Discussioncontrasting

confidence: 89%

Iron sequestration by macrophages decreases the potential for extracellular hydroxyl radical formation.

Olakanmi¹,

McGowan²,

Hayek³

et al. 1993

J. Clin. Invest.

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Section: Discussioncontrasting

confidence: 89%

Iron sequestration by macrophages decreases the potential for extracellular hydroxyl radical formation.

Olakanmi¹,

McGowan²,

Hayek³

et al. 1993

J. Clin. Invest.

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“…Myeloperoxidase (MPO), a haeme protein, is secreted from leukocytes in response to an inflammatory stimulus (Badwey & Karnovsky, 1980;Segal, 1989). The enzyme utilizes hydrogen peroxide released from activated leukocytes, (Tauber & Babior, 1977;Weiss et al, 1977) and singlet oxygen (Krinsky, 1974). In physiological media MPO gives rise to two main radical species, hypochlorous acid and tyrosyl radical (Heinecke et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

Dietary supplements of soya flour lower serum testosterone concentrations and improve markers of oxidative stress in men

et al. 2003

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Objective: We examined the effects on serum sex steroids, lipids and markers of oxidative stress of supplementing the diets of healthy male volunteers with scones made with soya flour. Design: A randomized placebo controlled cross-over trial. Setting: University Hospital of Wales. Subjects: Twenty volunteers recruited by advertisement. Interventions: Male volunteers ate three scones a day in addition to their normal diet for a period of 6 weeks. The scones were made with either wheat or soya flour (containing 120 mg=day of isoflavones). Blood was analysed for sex steroids (testosterone, dihydro-testosterone, oestradiol, oestrone, sex hormone binding globulin, albumin and the concentration of non-protein bound sex steroids were calculated), lipid profile (total cholesterol, high density lipoprotein cholesterol and triglycerides) and measures of oxidative stress (hydroperoxides, susceptibility of LDL to oxidation with copper and myeloperoxidase). Results: The volunteers' mean age was 35.6 (s.d. 11.2) y. Total serum testosterone fell in volunteers taking the soya scones (19.3 -18.2 nmol=l; 95% CI 1.01, 1.12; P ¼ 0.03). No significant changes were seen in the concentrations of the other serum sex steroids, albumin or sex hormone binding globulin throughout the study. Significant improvements in two of the three markers of oxidative stress were seen in volunteers taking soya scones. Lag time for myeloperoxidase rose from 55.0 to 68.0 min (95% CI 7 16.0, 7 3.5; P ¼ 0.009) and the presence of hydroperoxides decreased from 2.69 to 2.34 mmol=l (95% CI 0.12, 0.71; P ¼ 0.009). There were no changes seen in serum triglycerides or cholesterol. Conclusions: We have shown that soya supplements reduce serum testosterone and improve markers of oxidative stress. These findings provide a putative mechanism by which soya supplements could protect against prostatic disease and atherosclerosis. Further dietary studies with clinical end points are warranted.

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“…HOC1 is a potent oxidant which reacts readily with biological molecules. It is cytotoxic to a wide variety of mammalian cells [4]. Since HOC1 can account for at least 40% of the 02 generated during the respiratory burst [5], it may be responsible for most of the oxidant damage mediated by neutrophils [6].…”

Section: Introductionmentioning

confidence: 99%

Is there an unidentified defence mechanism against infection in human plasma?

et al. 1996

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The total peroxyl radical scavenging capacity (TRAP) of human plasma was measured from pneumonia patients and controls. TRAP and its main components, ascorbic acid, alpha-tocopherol, uric acid or protein thiol groups, were unaltered, but the concentration of unidentified antioxidants in pneumonia patients was significantly reduced. Our results indicate that human plasma may contain so far unidentified antioxidants depleted in infection.

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Evidence for hydroxyl radical generation by human Monocytes.

Cited by 156 publications

References 18 publications

Iron sequestration by macrophages decreases the potential for extracellular hydroxyl radical formation.

Iron sequestration by macrophages decreases the potential for extracellular hydroxyl radical formation.

Dietary supplements of soya flour lower serum testosterone concentrations and improve markers of oxidative stress in men

Is there an unidentified defence mechanism against infection in human plasma?

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