Evidence for induction of oxidative stress caused by chronic exposure of Chinese residents to arsenic contained in drinking water.

Pi, Jingbo; Yamauchi, Hiroshi; Kumagai, Yoshito; Sun, Guifan; Yoshida, Toshihide; Aikawa, Hiroyuki; Hopenhayn‐Rich, Claudia; Shimojo, Naoki

doi:10.1289/ehp.02110331

Cited by 246 publications

(158 citation statements)

References 56 publications

Supporting

Mentioning

143

Contrasting

Unclassified

Order By: Relevance

“…Arsenic is a human carcinogen (i.e., lung, skin, bladder, and liver; [Wickre et al, 2004;Yoshida et al, 2004] and populations in China have been shown to be exposed via drinking water and food consumption [Pi et al, 2002;Liu et al, 2003]. Toxic forms of arsenic include inorganic species (As 3+ and As 5+ ) as well as monomethylarsenite whereas arsenobetaines which are prevalent in seafood are considered benign [Shaw et al, 2007].…”

Section: Discussionmentioning

confidence: 99%

Mercury and Arsenic Bioaccumulation and Eutrophication in Baiyangdian Lake, China

Chen

Pickhardt

et al. 2007

Water Air Soil Pollut

View full text Add to dashboard Cite

Hg and As are widespread contaminants globally and particularly in Asia. We conducted a field study in Baiyangdian Lake, the largest lake in the North China Plain, to investigate bioaccumulation and trophic transfer of potentially toxic metals (total mercury and arsenic) in sites differing in proximity from the major point sources of nutrients and metals. Hg concentrations in fish and As concentrations in water are above critical threshold levels (US Environmental Protection Agency based) considered to pose some risk to humans and wildlife. Hg concentrations in biota are within the range of concentrations in lakes in the Northeast US despite the high levels of Hg emission and deposition in China whereas As concentrations are much higher. Dissolved concentrations of both Hg and As decrease with increasing chlorophyll concentrations suggesting that there is significant uptake of metal from water by algae. These results provide evidence for algal blooms controlling dissolved metal concentrations and potentially mitigating the trophic transfer of Hg to fish. This study also underscores the need for further investigation into this contaminated ecosystem and others like it in China that are an important source of fish and drinking water for consumption by local human populations.

show abstract

Section: Discussionmentioning

confidence: 99%

Mercury and Arsenic Bioaccumulation and Eutrophication in Baiyangdian Lake, China

Chen

Pickhardt

et al. 2007

Water Air Soil Pollut

View full text Add to dashboard Cite

show abstract

“…Quantitation of total iAs and trivalent arsenite [iAs(III)] in water and total iAs, MMA, DMA and trimethylarsenic (TMA) in urine were performed as reported previously (Yamauchi and Yamamura, 1984;Pi et al, 2002). Briefly, 0.20 ml urine samples were transferred into 20 ml polypropylene test tubes and after the addition of 0.80 ml 2 M sodium hydroxide to the sample, the mixture was heated at 951C for 3 h. The treated urine sample and the tube-well water sample were diluted to make a 2 ml sample.…”

Section: Analysis Of Arsenic In Urine and Tube-well Watermentioning

confidence: 99%

“…One Taiwanese study reported that ingestion of arsenic-contaminated well water may cause deleterious effects by increasing the level of reactive oxidants and decreasing the level of antioxidant capacity in the plasma of affected individuals (Wu et al, 2001). Another study reported that chronic exposure to arsenic in drinking water in humans results in induction of oxidative stress, as indicated by a reduction in nonprotein sulfydryl and an increase in lipid peroxides (Pi et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Chronic arsenic exposure and urinary 8-Hydroxy-2′-deoxyguanosine in an arsenic-affected area in Inner Mongolia, China

Fujino

Guo²,

Li³

et al. 2004

J Expo Sci Environ Epidemiol

View full text Add to dashboard Cite

Objective: Recent studies have shown that generation of reactive oxidants during arsenic metabolism can play an important role in arsenic-induced injury. The purpose of this study was to examine the relationship between arsenic in drinking water and oxidative stress in humans by measuring 8-Hydroxy-2 0 -deoxyguanosine (8-OHdG). Methods: We performed a cross-sectional study in an arsenic-affected village in Hetao Plain, Inner Mongolia, China. A total of 134 of the 143 inhabitants (93.7%) of the village participated in the study. The levels of 8-OHdG, arsenic and its metabolites were measured in urine collected from the participants. Regression analyses were performed to investigate the relationship between arsenic species and 8-OHdG levels in urine. Results: In the polluted village, monomethylarsenic was significantly higher in subjects with arsenic dermatosis than those without dermatosis despite no difference in mean levels of arsenic in well water between both types of subject. For subjects with arsenic dermatosis, arsenic species and metabolites in urine are significantly associated with 8-OHdG, while there was no statistically significant relationship for subjects without arsenic dermatosis. For all residents of the polluted village, the levels of dimethylarsenic and 8-OHdG were significantly higher for those who had been exposed to well water for more than 12 years. Conclusions: These results provide evidence of a link between exposure to arsenic from drinking water and oxidative stress, which may play an important role in arsenic-involved injuries.

show abstract

“…However, arsenic alone does not appear to induce skin cancer in these mouse models [2][3][4], suggesting events associated with arsenic-induced dermal carcinogenesis may be distinct from other target tissues. Accumulating evidence suggests that oxidative stress occurs in response to arsenic exposure [5,6] and may be one factor in dermal arsenic carcinogenesis. Indeed, evidence of arsenic-induced oxidative DNA damage has been observed in cells [7][8][9][10][11][12], in rodents [13] and in humans [14].…”

Section: Introductionmentioning

confidence: 99%

Arsenic-induced malignant transformation of human keratinocytes: Involvement of Nrf2

Diwan

Sun

et al. 2008

Free Radical Biology and Medicine

Self Cite

162

147

View full text Add to dashboard Cite

Arsenic is a well-known human skin carcinogen but the underlying mechanisms of carcinogenesis are unclear. Transcription factor Nrf2-mediated antioxidant response represents a critical cellular defense mechanism, and emerging data suggest that constitutive activation of Nrf2 contributes to malignant phenotype. In the present study when an immortalized, non-tumorigenic human keratinocyte cell line (HaCaT) was continuously exposed to environmentally relevant level of inorganic arsenite (100 nM) for 28 weeks, malignant transformation occurred as evidenced by the formation of highly aggressive squamous cell carcinoma after inoculation into nude mice. To investigate the mechanisms involved, a broad array of biomarkers for transformation were assessed in these arsenic-transformed cells (termed As-TM). In addition to increased secretion of matrix metalloproteinase-9 (MMP-9), a set of markers for squamous differentiation and skin keratinization, including keratin-1, keratin-10, involucrin, and loricrin, were significantly elevated in As-TM cells. Furthermore, As-TM cells showed increased intracellular glutathione, elevated expression of Nrf2 and its target genes, as well as generalized apoptotic resistance. In contrast to increased basal Nrf2 activity in As-TM cells, a diminished Nrf2-mediated antioxidant response induced by acute exposure to high dose of arsenite or tert-butyl hydroxyquinone occurred. The findings that multiple biomarkers for malignant transformation observed in As-TM cells, including MMP-9 and cytokeratins, are potentially regulated by Nrf2 suggest constitutive Nrf2 activation may be involved in arsenic carcinogenesis of skin. The weakened Nrf2 activation in response to oxidative stressors observed in As-TM cells, coupled with acquired apoptotic resistance, would potentially have increased the likelihood of transmittable oxidative DNA damage and fixation of mutational/DNA damage events.

show abstract

Evidence for induction of oxidative stress caused by chronic exposure of Chinese residents to arsenic contained in drinking water.

Cited by 246 publications

References 56 publications

Mercury and Arsenic Bioaccumulation and Eutrophication in Baiyangdian Lake, China

Mercury and Arsenic Bioaccumulation and Eutrophication in Baiyangdian Lake, China

Chronic arsenic exposure and urinary 8-Hydroxy-2′-deoxyguanosine in an arsenic-affected area in Inner Mongolia, China

Arsenic-induced malignant transformation of human keratinocytes: Involvement of Nrf2

Contact Info

Product

Resources

About