Evidence for involvement of NK3 receptors in the anxiogenic-like effect of SP6-11(C-terminal), a metabolite of substance P, in rats evaluated in the elevated plus-maze

Duarte, Filipe S.; Duzzioni, Marcelo; Leme, Leandro Rinaldi; Smith, Saulo de Paiva; Lima, Thereza Christina Monteiro de

doi:10.1016/j.bbr.2016.02.003

Cited by 11 publications

(2 citation statements)

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“…Consistent with our results, intracerebroventricular administration of the selective NK3R agonist senktide evokes gerbil foot tapping, which is thought to reflect a fear‐related response (Sundqvist et al., 2007). Likewise, NK3Rs may be responsible for the anxiogenic‐like actions of SP6‐11(C‐terminal), a specific metabolite of SP (Duarte et al., 2016). More specifically, up‐regulation of NKB and NK3Rs in the medial nucleus of CeA facilitates the consolidation of fear memories (Andero et al., 2016).…”

Section: Discussionmentioning

confidence: 99%

Ionic signalling mechanisms involved in neurokinin‐3 receptor‐mediated augmentation of fear‐potentiated startle response in the basolateral amygdala

Boyle

Quaintance

et al. 2022

The Journal of Physiology

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Section: Discussionmentioning

confidence: 99%

Ionic signalling mechanisms involved in neurokinin‐3 receptor‐mediated augmentation of fear‐potentiated startle response in the basolateral amygdala

Boyle

Quaintance

et al. 2022

The Journal of Physiology

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“…Regarding the EPM paradigm, a valuable feature is its ability to detect both anxiogenic and anxiolytic-like effects of drugs (Kshama et al 1990;Rodgers and Dalvi 1997;Griebel and Holmes 2013;Cipriano et al 2016;Duarte et al 2016). Given that anxiety is a heterogeneous emotional process and that the EPM seems to elicit unlearned anxiety, it would be interesting to expand the consequences of previous anesthesia to other paradigms of anxiety.…”

Section: Implications and Limitations Of The Studymentioning

confidence: 99%

Refinement of anesthetic choice in procedures preceding psychopharmacological studies

Gaigher

Siqueira

et al. 2018

Preprint

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RationalePrevious studies indicated that some general anesthetics induce long-term antidepressant and/or anxiolytic-like effects. This raises the concern about the use of anesthesia in surgeries that precede psycopharmacological tests, since it may be a potential bias on results depending on the experimental design used.ObjectivesTo evaluate whether commonly used general anesthetics in surgeries preceding psychopharmacological tests would affect rat behavior in tests predictive of antidepressant or anxiolytic-like effects. We also evaluated whether prior anesthesia would interfere in the detection of the antidepressant-like effect of imipramine or the anxiolytic-like effect of diazepam.MethodsWe tested if a single exposure to subanesthetic or anesthetic doses of 2,2,2-tribromoethanol, chloral hydrate, thiopental or isoflurane would change rat’s behavior in the forced swimming test (FST) or in the elevated plus-maze (EPM) test, at 2 hours or 7 days after administration.ResultsPrevious anesthesia with the aforementioned anesthetics did not change rat behavior in FST per se nor it changed the antidepressant-like effect induced by imipramine treatment. Rats previously anesthetized with tribromoethanol or chloral hydrate exhibited, respectively, anxiogenic-like or anxiolytic-like behavior in the EPM. Prior anesthesia with thiopental or isoflurane did not produce anyper seeffect in rat behavior in the EPM nor disturbed the anxiolytic-like effect of diazepam.ConclusionOur results suggest that, in our experimental conditions, tribromoethanol and chloral hydrate are improper anesthetics for surgeries that precede behavioral tests related to anxiety. Isoflurane or thiopental may be suitable for anesthesia before evaluation in animal models predictive of antidepressant or anxiolytic-like effect.

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Neurokinin/Tachykinin Receptors

Muñoz

Coveñas

2021

Encyclopedia of Molecular Pharmacology

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Evidence for involvement of NK3 receptors in the anxiogenic-like effect of SP6-11(C-terminal), a metabolite of substance P, in rats evaluated in the elevated plus-maze

Cited by 11 publications

References 56 publications

Ionic signalling mechanisms involved in neurokinin‐3 receptor‐mediated augmentation of fear‐potentiated startle response in the basolateral amygdala

Ionic signalling mechanisms involved in neurokinin‐3 receptor‐mediated augmentation of fear‐potentiated startle response in the basolateral amygdala

Refinement of anesthetic choice in procedures preceding psychopharmacological studies

Neurokinin/Tachykinin Receptors

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