Evidence for Involvement of the Subcoeruleus Nucleus and Nucleus Raphe Magnus in Urine Storage and Penile Erection in Decerebrate Rats

Sugaya, Kimio; Ogawa, Yoshihide; Hatano, Tadashi; Koyama, Yuzo; Miyazato, Tomonori; Oda, Masami

doi:10.1097/00005392-199806000-00143

Cited by 16 publications

(26 citation statements)

References 16 publications

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“…Although VMM stimulation did not evoke micturition, it did suppress on-going, subthreshold bladder contractions (data not shown), as has been reported previously (Sugaya et al, 1998). Bladder contractions become larger and occur more frequently with increasing vesicular pressure and are dependent on descending input from the brainstem (Sugaya et al, 1998).…”

Section: Vmm Activity Before Micturitionsupporting

confidence: 70%

“…Bladder contractions become larger and occur more frequently with increasing vesicular pressure and are dependent on descending input from the brainstem (Sugaya et al, 1998). These findings led us to consider whether VMM neurons play a preparatory role in the initiation of micturition, perhaps by modulating bladder afferent input.…”

Section: Vmm Activity Before Micturitionmentioning

confidence: 99%

“…Thus, the finding that void volumes for individual humans and rats vary by more than an order of magnitude across micturition episodes (Haas et al, 1997;Mattsson et al, 2003) suggests neural modulation of detrusor compliance and/or bladder afferent input. VMM neurons are likely one source of such modulation because VMM stimulation suppresses spontaneous subthreshold bladder contractions that are greater at increasing volumes (Sugaya et al, 1998) and inhibits resting activity in pelvic parasympathetic nerves to the bladder (McMahon and Spillane, 1982).…”

Section: Vmm Modulation Of Micturition Onsetmentioning

confidence: 99%

“…Because bladder contractions increase in frequency and size with increasing bladder pressure, require supraspinal input, and are inhibited by RM stimulation (Sugaya et al, 1998), RM may inhibit bladder afferent input. Therefore, we examined the effect of manipulating VMM cell activity on the initiation of micturition.…”

Section: Introductionmentioning

confidence: 99%

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Roles for Pain Modulatory Cells during Micturition and Continence

Baez¹,

Brink²,

Mason³

2005

J. Neurosci.

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Section: Vmm Activity Before Micturitionsupporting

confidence: 70%

Section: Vmm Activity Before Micturitionmentioning

confidence: 99%

Section: Vmm Modulation Of Micturition Onsetmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Roles for Pain Modulatory Cells during Micturition and Continence

Baez¹,

Brink²,

Mason³

2005

J. Neurosci.

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“…Yet, the ability of VMM activation to elicit a myriad of physiological effects and the anatomical pathways from VMM cells to autonomic targets (see above) make it likely that differences in ON and OFF cell discharge impact spinal processes other than nociception. For instance, during continence, ON and OFF cell discharge appears to influence the timing of micturition (Baez et al 2005;Sugaya et al 1998).…”

Section: P a T H W A Y S F R O M V M M T O S Y M P A T H E T I C A N mentioning

confidence: 99%

Deconstructing Endogenous Pain Modulations

Mason

2005

Journal of Neurophysiology

129

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Mason, Peggy. Deconstructing endogenous pain modulation. J Neurophysiol 94: 1659Neurophysiol 94: -1663Neurophysiol 94: , 2005 doi:10.1152/jn.00249.2005. A pathway from the midbrain periaqueductal gray (PAG) through the ventromedial medulla (VMM) to the dorsal horn constitutes a putative endogenous nociceptive modulatory system. Yet activation of neurons in both PAG and VMM changes the responses of dorsal horn cells to nonnoxious stimuli and elicits motor and autonomic reactions that are not directly related to nociception. Activation of mu-opioid receptors in VMM and PAG also modifies processes in addition to nociceptive transmission. The descending projections of VMM neurons are not specific to nociception as VMM projects to the spinal superficial dorsal horn where thermoreceptors as well as nociceptors terminate. In addition, experiments with pseudorabies virus demonstrate multisynaptic pathways from VMM to sympathetic and parasympathetic target organs. VMM neurons respond to both noxious and unexpected innocuous stimuli of multiple modalities, and change their discharge during behaviors unrelated to pain such as micturition/continence and sleep/wake. In conclusion, all available evidence argues against the idea that PAG and VMM target nociception alone. Instead these brain stem sites may effect homeostatic adjustments made necessary by salient situations including but not limited to injury.

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Medial vestibular connections with the hypocretin (orexin) system

2005

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The mammalian medial vestibular nucleus (MVe) receives input from all vestibular endorgans and provides extensive projections to the central nervous system. Recent studies have demonstrated projections from the MVe to the circadian rhythm system. In addition, there are known projections from the MVe to regions considered to be involved in sleep and arousal. In this study, afferent and efferent subcortical connectivity of the medial vestibular nucleus of the golden hamster (Mesocricetus auratus) was evaluated using cholera toxin subunit-B (retrograde), Phaseolus vulgaris leucoagglutinin (anterograde), and pseudorabies virus (transneuronal retrograde) tract-tracing techniques. The results demonstrate MVe connections with regions mediating visuomotor and postural control, as previously observed in other mammals. The data also identify extensive projections from the MVe to regions mediating arousal and sleep-related functions, most of which receive immunohistochemically identified projections from the lateral hypothalamic hypocretin (orexin) neurons. These include the locus coeruleus, dorsal and pedunculopontine tegmental nuclei, dorsal raphe, and lateral preoptic area. The MVe itself receives a projection from hypocretin cells. CTB tracing demonstrated reciprocal connections between the MVe and most brain areas receiving MVe efferents. Virus tracing confirmed and extended the MVe afferent connections identified with CTB and additionally demonstrated transneuronal connectivity with the suprachiasmatic nucleus and the medial habenular nucleus. These anatomical data indicate that the vestibular system has access to a broad array of neural functions not typically associated with visuomotor, balance, or equilibrium, and that the MVe is likely to receive information from many of the same regions to which it projects.

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Evidence for Involvement of the Subcoeruleus Nucleus and Nucleus Raphe Magnus in Urine Storage and Penile Erection in Decerebrate Rats

Abstract: This electrophysiological study demonstrated that the subcoeruleus nucleus and nucleus raphe magnus are involved in both urine storage and penile erection, and that their physiological functions are reciprocally controlled; so that erection leads to inhibition of micturition.

Cited by 16 publications

References 16 publications

Roles for Pain Modulatory Cells during Micturition and Continence

Roles for Pain Modulatory Cells during Micturition and Continence

Deconstructing Endogenous Pain Modulations

Medial vestibular connections with the hypocretin (orexin) system

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