Evidence for lipid peroxidation in atherosclerosis

Piotrowski, Joseph J.; Hunter, Glenn C.; Eskelson, Cleamond D.; Dubick, Michael A.; Bernhard, Victor M.

doi:10.1016/0024-3205(90)90077-5

Cited by 54 publications

(43 citation statements)

References 8 publications

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“…Despite the high polyunsaturation of PtdIns, neither hydroperoxides nor isoprostanes or core aldehydes were found in the present study. Piotrowski et al (30,35) found a linear relationship between total PtdCho and PtdIns and their peroxide content, but the PtdEtn showed no such relationship. Piotrowski et al (30) determined the total phospholipid hydroperoxides in mature atherosclerotic plaques by means of a fluorometric assay.…”

Section: Resultsmentioning

confidence: 96%

Phospholipids and oxophospholipids in atherosclerotic plaques at different stages of plaque development

Ravandi

Babaei²,

Leung³

et al. 2004

Lipids

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We identified and quantified the hydroperoxides, hydroxides, epoxides, isoprostanes, and core aldehydes of the major phospholipids as the main components of the oxophospholipids (a total of 5-25 pmol/micromol phosphatidylcholine) in a comparative study of human atheroma from selected stages of lesion development. The developmental stages examined included fatty streak, fibrous plaque, necrotic core, and calcified tissue. The lipid analyses were performed by normal-phase HPLC with on-line electrospray MS using conventional total lipid extracts. There was great variability in the proportions of the various oxidation products and a lack of a general trend. Specifically, the early oxidation products (hydroperoxides and epoxides) of the glycerophosphocholines were found at the advanced stages of the plaques in nearly the same relative abundance as the more advanced oxidation products (core aldehydes and acids). The anticipated linear accumulation of the more stable oxidation products with progressive development of the atherosclerotic plaque was not apparent. It is therefore suggested that lipid infiltration and/or local peroxidation is a continuous process characterized by the formation and destruction of both early and advanced products of lipid oxidation at all times. The process of lipid deposition appears to have been subject to both enzymatic and chemical modification of the normal tissue lipids. Clearly, the appearance of new and disproportionate old lipid species excludes randomness in any accumulation of oxidized LDL lipids in atheroma.

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Section: Resultsmentioning

confidence: 96%

Phospholipids and oxophospholipids in atherosclerotic plaques at different stages of plaque development

Ravandi

Babaei²,

Leung³

et al. 2004

Lipids

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“…(Hennig and Chow;Esterbauer et al 1989;Stam et al 1989;Steinberg et al 1989;Rumley et al 2004). DiCorleto and Chisalm (1986), Palinski et al (1989), Piotrowski et al (1990), Glovind et al (1992) anticipated that ROS produced by macrophages and white blood cells along with an increased local concentration of oxidized low-density lipoproteins (oxLDL) give rise to endothelial damage as a first step of atheromatous plaque formation and altered vessel function. The products of lipid peroxidation accumulated in endothelial cells (Hennig and Chow 1988) inhibit eNOS (Fig.…”

Section: Increased Lipid Peroxidation and Oxidized Low-density Lipoprmentioning

confidence: 99%

Nitric oxide – the endothelium-derived relaxing factor and its role in endothelial functions

Bauer¹,

Sotníková²

2010

gpb

134

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Abstract. Vascular endothelium plays a key role in the local regulation of vascular tone and vascular architecture by release of vasodilator and vasoconstrictor substances, as well as factors with pro-coagulant, anticoagulant, fibrinolytic, antibacterial properties, growth factors, chemokines, free radicals, etc. Release of endothelium-derived relaxing factors such as nitric oxide (NO), prostaglandins and endothelium-derived hyperpolarizing factor, as well as vasoconstricting factors such as endothelin, superoxide and thromboxanes play an influential role in the maintenance and regulation of vascular tone and the corresponding peripheral vascular resistance. Under physiological conditions, the release of anticoagulant and smooth muscle relaxing factors exceeds the release of other substances. The first part of this review presents the functions of the endothelium itself, the nature of the endothelium-derived relaxing factor, its production by NO synthases, mechanisms of its action via activation of soluble guanylyl cyclase and production of cyclic 3'-5'-guanosine monophosphate. The resulting biological effects include vasodilatation, regulation of vessel wall structure, increased regional blood perfusion, lowering of systemic blood pressure, antithrombosis and antiatherosclerosis effects, which counteract the vascular actions of endogenous vasoconstrictor substances. Impaired endothelial function, either as a consequence of reduced production/release or increased inactivation of endothelium-derived vasodilators, as well as interactions of NO with angiotensin, reactive oxygen species and oxidized lipoproteins, has detrimental functional consequences and is one of the most important cardiovascular risk factors. Therefore the second part of this review assesses the pathophysiologic impact of the endothelium in examples of cardiovascular pathologies, e.g. endotheliopathies caused by increased angiotensin production, lipid peroxidation, ischemia/reperfusion or diabetes.

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“…ROS and RNS induce all forms of DNA damage, including base modifications, base-free (apurinic and pyrimidinic) sites, strand breakage, and DNA-protein cross links [2]. Radical-related damage of DNA and proteins have been proposed to play a key role in the development of age-dependent diseases such as cancer [3], atherosclerosis [4,5], arthritis [6], and neurodegenerative disorders [7]. Antioxidant compounds are able to protect the human body against damage by ROS and RNS [8].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antioxidant Properties of Novel N‐H and N‐Substituted Propanamide Derivatives

Ölgen

Kılıç

Ada

et al. 2007

Archiv der Pharmazie

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The interest in the application of antioxidants for medical treatment has been growing recently. A lot of evidence has proven the link between the development of human diseases and oxidative stress. Indole derivatives were found to be very effective in protecting against oxidative stress. Recent exciting findings have demonstrated that several indole derivatives (IDs) are strong inhibitors of superoxide anion (SOD) and lipid peroxidation (LP). In this study, a series of novel N-H and N-substituted indole-3-propanamide derivatives (I3PADs) have been prepared and their efficiencies were investigated towards SOD and LP. Among the synthesized I3PADs, compounds 5 and 7-12 significantly inhibited O2*- in the range of 94-100%. In addition, N-H I3PADs showed a stronger inhibitory effect (compounds 1-5, 56-83%) on lipid peroxidation levels than SOD.

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Evidence for lipid peroxidation in atherosclerosis

Cited by 54 publications

References 8 publications

Phospholipids and oxophospholipids in atherosclerotic plaques at different stages of plaque development

Phospholipids and oxophospholipids in atherosclerotic plaques at different stages of plaque development

Nitric oxide – the endothelium-derived relaxing factor and its role in endothelial functions

Synthesis and Antioxidant Properties of Novel N‐H and N‐Substituted Propanamide Derivatives

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