Evidence for low-grade systemic proinflammatory activity in patients with posttraumatic stress disorder

Känel, Roland von; Hepp, Urs; Kraemer, Bernd; Traber, Rafael; Keel, Marius; Mica, Ladislav; Schnyder, Ulrich

doi:10.1016/j.jpsychires.2006.06.009

Cited by 369 publications

(288 citation statements)

References 40 publications

Supporting

Mentioning

256

Contrasting

Unclassified

Order By: Relevance

“…Finally, we should note that 9 months after the earthquake, the incidence of PTSD was still high among female high school students in earthquake areas without severe property damage. It has been reported that PTSD is associated with a low-grade systemic proinflammatory state, which could contribute to atherosclerosis (von Känel et al 2007). Moreover, PTSD in adolescents has been suggested to be associated with the objective disease states, such as circulatory disease (Seng et al 2005).…”

Section: Discussionmentioning

confidence: 99%

Premenstrual Symptoms and Posttraumatic Stress Disorder in Japanese High School Students 9 Months after the Great East-Japan Earthquake

Takeda

Tadakawa

Koga

et al. 2013

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

On March 11, 2011, the Great East-Japan Earthquake occurred and a massive tsunami hit the northeastern coast of Japan. Catastrophic disasters such as earthquakes and war cause tremendous damage, not only physically but also mentally. Posttraumatic stress disorder (PTSD) is an anxiety disorder that occurs in the aftermath of a traumatic event. Premenstrual syndrome (PMS) is a cluster of psychological and somatic symptoms that are limited to the late luteal phase of the menstrual cycle. Premenstrual dysphoric disorder (PMDD) is considered a severe form of PMS. To determine the relationship between premenstrual symptoms and natural disaster-induced PTSD among Japanese adolescent girls, we conducted a crosssectional study. Overall, 1489 high school students who belong to two high schools in Sendai, the largest city in northeastern Japan, were assessed 9 months after the earthquake. These schools are located inland, far from the seashore, and were not damaged by the tsunami. Premenstrual symptoms were assessed using the Premenstrual Symptoms Questionnaire, and PTSD symptoms were assessed using the Japanese-language version of Impact of Event Scale-Revised, which is a widely used self-assessment questionnaire about PTSD symptoms. We analyzed the data of 1,180 girls who completed the questionnaires and 118 girls (10.0%) were classified as having PTSD. The prevalence rates of PMDD and moderate to severe PMS increased according to the comorbidity of PTSD (p < 0.001), showing a correlation between the severity of PMS/PMDD and natural disaster-induced PTSD. The comorbidity of PMS/PMDD and PTSD may complicate the follow-up of both conditions.

show abstract

Section: Discussionmentioning

confidence: 99%

Premenstrual Symptoms and Posttraumatic Stress Disorder in Japanese High School Students 9 Months after the Great East-Japan Earthquake

Takeda

Tadakawa

Koga

et al. 2013

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

show abstract

“…Two studies found elevated levels of anxiety and PTSD to be independently associated with abnormal levels of acute-phase proteins and several proinflammatory cytokines (e.g., IL-6 and TNF-α in cardiac patients) [60]. In addition, Type D personality was associated with higher levels of proinflammatory cytokines and lower levels of anti-inflammatory cytokines in patients with heart failure [61].…”

Section: Inflammationmentioning

confidence: 99%

Psychological vulnerability, ventricular tachyarrhythmias and mortality in implantable cardioverter defibrillator patients: is there a link?

Pedersen

Brouwers

Versteeg

2012

Expert Review of Medical Devices

View full text Add to dashboard Cite

show abstract

“…Extensive research has shown that chronic neuroinflammation continues for months to years after injury, [9][10][11][12] and evidence for chronic inflammation has been observed in a number of studies examining patients with PTSD, panic disorder, obsessive-compulsive disorder (OCD), and generalized anxiety disorder. [13][14][15][16][17][18] Glial activation may be involved in the development and maintenance of PTSD, [9][10][11][12] and mounting evidence supports the role of inflammatory processes in both TBI and anxiety disorders. After injury, immune cells rapidly produce endogenous danger signals or ''alarmins,'' which function as potent effectors of innate defense and promote immune system activation by recruiting antigen-presenting cells (APCs) that relay and amplify the inflammatory response.…”

mentioning

confidence: 99%

“…inflammatory response in the brain that exceeds early neuroprotection and results in neurodegenerative changes capable of continuing the inflammatory cycle. 9,27,90 Chronic inflammation has been observed in a number of studies examining patients with trauma-related anxiety disorders, reporting increases in downstream mediators, such as peripheral elevations of TNF-a, interferon-gamma (IFN-c), IL-1b, and IL-6, in patients with PTSD, [13][14][15][16] elevations of TNF-a and IL-6 in patients with OCD, 17 and elevations in proinflammatory cytokines and chemokines (monocyte chemoattractant protein 1, macrophage inflammatory protein 1 alpha, IL-1a, IL-1b, IL-6, IL-8, Eotaxin, granulocyte macrophage colony-stimulating factor, and IFN-c) in individuals with panic disorder and PTSD. 18 Despite compelling evidence implicating excessive inflammatory actions and a generalized inflammatory state in the development of anxiety disorders after TBI, central measures of proinflammatory cytokine elevations specifically related to human PTSD and other anxiety disorders have not yet been performed.…”

mentioning

confidence: 99%

Reversal of Established Traumatic Brain Injury-Induced, Anxiety-Like Behavior in Rats after Delayed, Post-Injury Neuroimmune Suppression

Rodgers

Deming

Bercum

et al. 2014

Journal of Neurotrauma

View full text Add to dashboard Cite

Traumatic brain injury (TBI) increases the risk of neuropsychiatric disorders, particularly anxiety disorders. Yet, there are presently no therapeutic interventions to prevent the development of post-traumatic anxiety or effective treatments once it has developed. This is because, in large part, of a lack of understanding of the underlying pathophysiology. Recent research suggests that chronic neuroinflammatory responses to injury may play a role in the development of post-traumatic anxiety in rodent models. Acute peri-injury administration of immunosuppressive compounds, such as Ibudilast (MN166), have been shown to prevent reactive gliosis associated with immune responses to injury and also prevent lateral fluid percussion injury (LFPI)-induced anxiety-like behavior in rats. There is evidence in both human and rodent studies that post-traumatic anxiety, once developed, is a chronic, persistent, and drug-refractory condition. In the present study, we sought to determine whether neuroinflammation is associated with the long-term maintenance of post-traumatic anxiety. We examined the efficacy of an anti-inflammatory treatment in decreasing anxiety-like behavior and reactive gliosis when introduced at 1 month after injury. Delayed treatment substantially reduced established LFPI-induced freezing behavior and reactive gliosis in brain regions associated with anxiety and continued neuroprotective effects were evidenced 6 months post-treatment. These results support the conclusion that neuroinflammation may be involved in the development and maintenance of anxiety-like behaviors after TBI.

show abstract

Evidence for low-grade systemic proinflammatory activity in patients with posttraumatic stress disorder

Cited by 369 publications

References 40 publications

Premenstrual Symptoms and Posttraumatic Stress Disorder in Japanese High School Students 9 Months after the Great East-Japan Earthquake

Premenstrual Symptoms and Posttraumatic Stress Disorder in Japanese High School Students 9 Months after the Great East-Japan Earthquake

Psychological vulnerability, ventricular tachyarrhythmias and mortality in implantable cardioverter defibrillator patients: is there a link?

Reversal of Established Traumatic Brain Injury-Induced, Anxiety-Like Behavior in Rats after Delayed, Post-Injury Neuroimmune Suppression

Contact Info

Product

Resources

About