Evidence for modality-specific but not frequency-specific modulation of human primary auditory cortex by attention

Gander, Phillip E.; Bosnyak, Daniel J.; Roberts, Larry E.

doi:10.1016/j.heares.2010.06.003

Cited by 33 publications

(38 citation statements)

References 46 publications

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“…3a, collapsed over the tinnitus and control groups. These topographies and waveforms are similar to those we have observed previously when probing control and tinnitus subjects with 500 Hz and 5 kHz 40-Hz AM stimuli (Roberts et al, 2012;Paul et al, 2014) and normal hearing subjects with 2 kHz 40-Hz AM stimuli (Gander et al, 2010a(Gander et al, , 2010b. Following practices adopted in these previous studies, a Fourier transform was applied to the two-pulse waveforms for each subject.…”

Section: Electrophysiological Recordingsupporting

confidence: 74%

“…2007) and the transient N1 response known to localize to distributed sources in the region of the auditory parabelt (called here nonprimary auditory cortex, A2). ASSR sources show a coarse but consistent low-frequency anterolateral, high-frequency posteromedial tonotopic organization (Pantev et al, 1996;Wienbruch et al, 2006;Gander et al, 2010a) that reflects the summation of extracellular field potentials across two cochleotopic maps with strong low-frequency anterolateral and high-frequency posteromedial activations in Heschl's gyrus (Langers et al, 2012). In contrast, N1 sources localize to distributed and cytoarchitectonically heterogeneous regions of A2 (Godey et al, 2001) where tonotopy is lacking or not strongly expressed (Schreiner and Cynader, 1984;Langers et al, 2007;Lütkenh€ oner et al, 2003).…”

Section: Introductionmentioning

confidence: 98%

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Evidence for differential modulation of primary and nonprimary auditory cortex by forward masking in tinnitus

et al. 2015

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It has been proposed that tinnitus is generated by aberrant neural activity that develops among neurons in tonotopic of regions of primary auditory cortex (A1) affected by hearing loss, which is also the frequency region where tinnitus percepts localize (Eggermont and Roberts 2004; Roberts et al., 2010, 2013). These models suggest (1) that differences between tinnitus and control groups of similar age and audiometric function should depend on whether A1 is probed in tinnitus frequency region (TFR) or below it, and (2) that brain responses evoked from A1 should track changes in the tinnitus percept when residual inhibition (RI) is induced by forward masking. We tested these predictions by measuring (128-channel EEG) the sound-evoked 40-Hz auditory steady-state response (ASSR) known to localize tonotopically to neural sources in A1. For comparison the N1 transient response localizing to distributed neural sources in nonprimary cortex (A2) was also studied. When tested under baseline conditions where tinnitus subjects would have heard their tinnitus, ASSR responses were larger in a tinnitus group than in controls when evoked by 500 Hz probes while the reverse was true for tinnitus and control groups tested with 5 kHz probes, confirming frequency-dependent group differences in this measure. On subsequent trials where RI was induced by masking (narrow band noise centered at 5 kHz), ASSR amplitude increased in the tinnitus group probed at 5 kHz but not in the tinnitus group probed at 500 Hz. When collapsed into a single sample tinnitus subjects reporting comparatively greater RI depth and duration showed comparatively larger ASSR increases after masking regardless of probe frequency. Effects of masking on ASSR amplitude in the control groups were completely reversed from those in the tinnitus groups, with no change seen to 5 kHz probes but ASSR increases to 500 Hz probes even though the masking sound contained no energy at 500 Hz (an "off-frequency" masking effect). In contrast to these findings for the ASSR, N1 amplitude was larger in tinnitus than control groups at both probe frequencies under baseline conditions, decreased after masking in all conditions, and did not relate to RI. These results suggest that aberrant neural activity occurring in the TFR of A1 underlies tinnitus and its modulation during RI. They indicate further that while neural changes occur in A2 in tinnitus, these changes do not reflect the tinnitus percept. Models for tinnitus and forward masking are described that integrate these findings within a common framework.

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Section: Electrophysiological Recordingsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 98%

Evidence for differential modulation of primary and nonprimary auditory cortex by forward masking in tinnitus

et al. 2015

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“…Because the task administered in the T R stage was a training task, it necessarily required not only attention to the training stimuli, but also behavioural responses and the provision of knowledge of results. Companion experiments by Gander et al (2010) discussed later confirmed that attention to the auditory signals is the element responsible for the effects of task on ASSR amplitude that were found in the T R stage.…”

Section: Design and Proceduresmentioning

confidence: 74%

“…Results reported by Gander et al (2010) indicate that among these elements attention was the variable responsible for the increase in ASSR amplitude observed in active compared to passive conditions. Gander et al (2010) presented participants with simultaneous 40-Hz auditory and 16-Hz AM visual stimuli of 1 s duration, two-thirds of which contained single AM pulses (auditory or visual, or both, determined randomly) of enhanced amplitude (targets). In alternating blocks participants attended to either the auditory or the visual stream and indicated with a button press after each trial whether the stimulus contained or did not contain a target.…”

Section: Effects Of Active/passive Task On Assr Amplitudementioning

confidence: 94%

“…This response reaches its amplitude maximum when sounds are amplitude modulated (AM) at rates near 40 Hz (Ross et al, 2000) and localize in intracerebral recordings to posterior-medial Heschl's gyrus (Bidet-Caulet et al, 2007;Brugge et al, 2009), which is believed to correspond to the region of A1 in the human brain. ASSR sources determined by inverse modeling from MEG (Pantev et al, 1996b;Wienbruch et al, 2006) and EEG (Gander et al, 2010) data show a high-frequency medial, low-frequency lateral tonotopic ordering in this region that is consistent with tonotopic organization described in human fMRI studies (Formisano et al, 2003;Petkov et al, 2004) and with reversing tonotopic maps in A1 of the macaque monkey, which share a low-frequency border situated laterally in the superior temporal gyrus (Kaas and Hackett, 2000). The ASSR waveform extracted by temporal deconvolution of ASSRs recorded at AM rates from 10 to 50 Hz approximates the Na/Pa/Nb/Pb waveform of auditory "middle latency" responses that are evoked in the interval w19e55 ms post-stimulus and represent the earliest stages of sound processing in the auditory cortex (Gutschalk et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

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Acoustic experience but not attention modifies neural population phase expressed in human primary auditory cortex

2010

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Sustained selective intermodal attention modulates processing of language-like stimuli

et al. 2011

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Intermodal attention (IA) is assumed to allocate limited neural processing resources to input from one specific sensory modality. We investigated effects of sustained IA on the amplitude of a 40-Hz auditory (ASSR) and a 4.3-Hz visual steady-state response (VSSR). To this end, we concurrently presented amplitude-modulated multi-speech babble and a stream of nonsense letter sets to elicit the respective brain responses. Subjects were cued trialwise to selectively attend to one of the streams for several seconds where they had to perform a lexical decision task on occasionally occurring words and pseudowords. Attention to the auditory stream led to greater ASSR amplitudes than attention to the visual stream. Vice versa, the VSSR amplitude was greater when the visual stream was attended. We demonstrate that IA research by means of frequency tagging can be extended to complex stimuli as used in the current study. Furthermore, we show not only that IA selectively modulates processing of concurrent multisensory input but that this modulation occurs during trial-by-trial cueing of IA. The use of frequency tagging may be suitable to study the role of IA in more naturalistic setups that comprise a larger number of multisensory signals.

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Evidence for modality-specific but not frequency-specific modulation of human primary auditory cortex by attention

Cited by 33 publications

References 46 publications

Evidence for differential modulation of primary and nonprimary auditory cortex by forward masking in tinnitus

Evidence for differential modulation of primary and nonprimary auditory cortex by forward masking in tinnitus

Acoustic experience but not attention modifies neural population phase expressed in human primary auditory cortex

Sustained selective intermodal attention modulates processing of language-like stimuli

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