Evidence for modulation of facial emotional processing bias during emotional expression decoding by serotonergic and noradrenergic antidepressants: an event-related potential (ERP) study

Kerestes, Rebecca; Labuschagne, Izelle; Croft, Rodney J.; O’Neill, Barry V.; Bhagwagar, Zubin; Phan, K. Luan; Nathan, Pradeep J.

doi:10.1007/s00213-008-1340-3

Cited by 37 publications

(27 citation statements)

References 96 publications

(168 reference statements)

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“…However, acute SSRI administration did decrease threat recognition in previously depressed patients [50] . It was also found to enhance LPPs to sad versus neutral faces in healthy males [51] , though a subsequent study did not replicate this [52] .…”

Section: Serotonin and Facial Processingmentioning

confidence: 84%

“…As such, given the varied findings, few inferences regarding the LPP to emotive stimuli in MDD can be drawn. Direct modulations of 5-HT activity via acute SSRI administration in healthy individuals induced an enhanced LPP to sad versus neutral faces [51] and no effects [52] . The latter is consistent with our finding of an unaltered LPP following 5-HT modulations to specific emotive stimuli.…”

Section: Discussionmentioning

confidence: 99%

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Acute Tryptophan Depletion Effects on the Vertex and Late Positive Potentials to Emotional Faces in Individuals with a Family History of Depression

Jaworska¹,

Thompson²,

Shah³

et al. 2011

Neuropsychobiology

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Background: Depression, which is associated with dysfunctional serotonin (5-HT) activity, may be characterized by impaired emotional information processing. This study assessed the effects of acute tryptophan depletion (TRP–), which transiently lowers CNS 5-HT, on the emotion-sensitive vertex positive potential (VPP) and late positive potential (LPP) event-related potentials (ERPs) and mood in individuals with a family history of depression. The VPP and LPP are thought to index the early and later stages of motivated attentional processing, respectively. Method: Within a double-blind balanced design, ERPs were acquired in 18 individuals with a family history of depression (12 females) after TRP– and TRP+ (balanced) treatment while participants were presented with facial expressions (neutral, as well as sad, joy and surprise at 50 and 100% intensity) and responded to surprised faces. Results: TRP– increased total mood disturbance and maintained depression scores. The VPP and LPP were larger to intense versus mild expressions. Enhanced processing of emotional versus neutral faces, as indexed by the VPP, was primarily evident with TRP–. Speeded and enhanced processing of intensely joyful versus mildly sad faces was found with TRP– (VPP indexed). Compared with TRP+, TRP also increased the VPP to mildly joyful faces. Conclusion: Transient 5-HT decreases in individuals with a family history of depression induce subtle changes in early stages of motivated emotional processing, though not in later ones.

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Section: Serotonin and Facial Processingmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Acute Tryptophan Depletion Effects on the Vertex and Late Positive Potentials to Emotional Faces in Individuals with a Family History of Depression

Jaworska¹,

Thompson²,

Shah³

et al. 2011

Neuropsychobiology

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“…In another study, citalopram and reboxetine increased the N250 amplitude for happy relative to sad facial expression (Kerestes et al 2009), however without an effect on behavior and mood. Application of citalopram and reboxetine over 7 days resulted in no significant changes of mood in healthy subjects (Harmer et al 2004) and had no effect on the recognition of happy facial expression, but decreased the recognition of disgusted, angry, and afraid expressions and the emotion-potentiated startle response to negative stimuli, thus pointing to an effect on the processing of negative stimuli.…”

Section: Discussionmentioning

confidence: 95%

Differential modulation of emotion processing brain regions by noradrenergic and serotonergic antidepressants

Brühl¹,

Jäncke

Herwig

2011

Psychopharmacology

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The brain regions involved in the processing of negative emotional stimuli were differentially modulated by selective noradrenergic and serotonergic drugs: thalamic activity was increased by reboxetine, whereas citalopram primarily affected ventrolateral prefrontal regions. Thus, dysfunction in these regions, which could be identified in depressed patients, may predict treatment responses to either noradrenergic or serotonergic antidepressants.

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“…Although many of these tasks involve the explicit and effortful control of emotion (McRae et al, 2010;Ochsner & Gross, 2005;Phan et al, 2005), a number of techniques have been developed recently to specifically alter the habitual deployment of attention to emotional information (Dandeneau, Baldwin, Baccus, Sakellaropoulo, & Pruessner, 2007; sants alter activity in frontal control regions; two studies reported such an effect (Fales et al, 2009;Kennedy et al, 2001), although both of these involved clinical populations, indicating that the findings may have been secondary to improved clinical status, rather than a treatment effect. An event-related potential (ERP) study has examined the effects of citalopram and reboxetine on the processing of emotional information in healthy volunteers (Kerestes et al, 2009). The high temporal acuity of ERP allowed the authors to demonstrate that both antidepressants influenced processing relatively shortly after stimulus presentation (250 msec), with the effect being found in a component of the ERP known to be sensitive to spatial attention (Eimer, Holmes, & McGlone, 2003).…”

Section: Psychological Methods Of Modulating Attention To Emotional Imentioning

confidence: 99%

The modification of attentional bias to emotional information: A review of the techniques, mechanisms, and relevance to emotional disorders

Browning

Holmes

Harmer

2010

Cognitive, Affective, & Behavioral Neuroscience

218

141

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8A wealth of data from behavioral, neuroimaging, pharmacological, and genetic studies has served to highlight the centrality of attentional processes in our understanding of anxiety and depression. Aberrant deployment of attention, particularly in relation to emotional information, occupies a pivotal position in many of the contemporary models of these disorders in which it is considered a causally relevant, proximal illness process. This view suggests that interventions that modify the habitual deployment of attention to emotional information should impact upon illness expression. In the present article, we will review the evidence that emotional attention may be modified in both experimental and clinical settings. In doing so, we will highlight the data that demonstrate that this modification may be achieved by targeting at least two distinct control mechanisms. Finally, we will consider the implications of this work, particularly with regard to future research and treatment development. What Evidence Links Abnormalities of Emotional Attention and the Emotional Disorders?Both depression and anxiety have been associated with biases in the processing of emotional information; patients with these disorders habitually interpret, attend to, and/or remember information in a more negative manner than do nonclinical control participants (Mathews & MacLeod, 2005). Cognitive theorists suggest that these habits of thought are causal factors in the etiology and maintenance of the disorders (Beck, 1976;Mathews & Mackintosh, 1998;Mathews & MacLeod, 2005;Mogg & Bradley, 1998;Williams, Watts, MacLeod, & Mathews, 1997). Anxiety has particularly been associated with a tendency to attend to threatening information-a phenomenon that has been termed negative attentional bias (see Figure 1 for a summary of the tasks commonly used to assess attentional bias; Fox, Russo, & Georgiou, 2005;MacLeod, Campbell, Rutherford, & Wilson, 2004;Mathews & MacLeod, 1985;Williams, Mathews, & MacLeod, 1996). Recent work, much of it discussed in the body of this article, has employed simple computer-based tasks in order to induce attentional biases in nonclinical populations (for reviews, see MacLeod, Koster, & Fox, 2009;Mathews & MacLeod, 2002). Critically for psychopathology, these studies provide direct support for a causal role of attention in anxiety by demonstrating that inducing a negative attentional bias can lead to symptoms of anxiety in nonclinical participants.In depression, the most consistent cognitive abnormalities were initially described in measures of memory (Gilboa-Schechtman, Erhard-Weiss, & Jeczemien, 2002;Mathews & MacLeod, 2005;Ridout, Astell, Reid, Glen, & O'Carroll, 2003;Williams et al., 1997); however, there has been increasing interest in the possibility that attentional biases may exist in this disorder as well. Specifically, depression has been shown to be associated with a tendency to attend to the spatial location of negative words (Bradley, Mogg, & Lee, 1997;Donaldson, Lam, & Mathews, 2007;Mogg, Bradley, & Williams, 19...

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Evidence for modulation of facial emotional processing bias during emotional expression decoding by serotonergic and noradrenergic antidepressants: an event-related potential (ERP) study

Cited by 37 publications

References 96 publications

Acute Tryptophan Depletion Effects on the Vertex and Late Positive Potentials to Emotional Faces in Individuals with a Family History of Depression

Acute Tryptophan Depletion Effects on the Vertex and Late Positive Potentials to Emotional Faces in Individuals with a Family History of Depression

Differential modulation of emotion processing brain regions by noradrenergic and serotonergic antidepressants

The modification of attentional bias to emotional information: A review of the techniques, mechanisms, and relevance to emotional disorders

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