Evidence for neurotoxicity and oxidative stress in zebrafish embryos/larvae treated with HFPO-DA ammonium salt (GenX)

Ivantsova, Emma; Lopez-Scarim, Victoria; Sultan, Amany; English, Cole; Biju, Angel; Souders, Christopher L.; Padillo-Anthemides, Natalia E.; Konig, Isaac; Martyniuk, Christopher J.

doi:10.1016/j.etap.2023.104315

Cited by 4 publications

(2 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Commonly studied alternatives for the legacy chemicals PFOA, PFOS, and PFHxS include PFBS, PFHpA, 6:2 FTS, 6:2 FTSA, Gen-X, PFBA, PFHpS, and PFNA. Embryonic exposure to all of these chemicals, except 6:2 FST, caused alterations in larvae locomotion and photomotor (movement in response to light) response [129][130][131][132][133][134][135][136]. In terms of neurodevelopmental effects, studies showed that early-life GenX and PFHxA exposure caused an alteration in genes related to neuron differentiation and growth [129,136].…”

Section: Pfas and Zebrafishmentioning

confidence: 99%

“…Embryonic exposure to all of these chemicals, except 6:2 FST, caused alterations in larvae locomotion and photomotor (movement in response to light) response [129][130][131][132][133][134][135][136]. In terms of neurodevelopmental effects, studies showed that early-life GenX and PFHxA exposure caused an alteration in genes related to neuron differentiation and growth [129,136]. PFBA exposure led to an increase in the enrichment of pathways associated with neurological disorders and neurodevelopment [132].…”

Section: Pfas and Zebrafishmentioning

confidence: 99%

See 1 more Smart Citation

Regrettable Substitutes and the Brain: What Animal Models and Human Studies Tell Us about the Neurodevelopmental Effects of Bisphenol, Per- and Polyfluoroalkyl Substances, and Phthalate Replacements

Morales-Grahl,

Hilz,

Gore

2024

IJMS

View full text Add to dashboard Cite

In recent decades, emerging evidence has identified endocrine and neurologic health concerns related to exposure to endocrine-disrupting chemicals (EDCs), including bisphenol A (BPA), certain per- and polyfluoroalkyl compounds (PFASs), and phthalates. This has resulted in consumer pressure to remove these chemicals from the market, especially in food-contact materials and personal care products, driving their replacement with structurally or functionally similar substitutes. However, these “new-generation” chemicals may be just as or more harmful than their predecessors and some have not received adequate testing. This review discusses the research on early-life exposures to new-generation bisphenols, PFASs, and phthalates and their links to neurodevelopmental and behavioral alterations in zebrafish, rodents, and humans. As a whole, the evidence suggests that BPA alternatives, especially BPAF, and newer PFASs, such as GenX, can have significant effects on neurodevelopment. The need for further research, especially regarding phthalate replacements and bio-based alternatives, is briefly discussed.

show abstract