Evidence for Persistent Radiation-Related Injury to the Immune System in Patients With Local Breast Cancer

Athale, Janhavi; Broderick, Kristen; Wu, Xiaojun; Grossman, Stuart A.

doi:10.1016/j.ijrobp.2022.11.028

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…If an association between TILs and response to RT could be demonstrated, it would establish the predictive value of TILs as marker of response to RT and open the way to biomarker-guided RT, plus, this would also add to evidence that the effect of RT might be partially mediated by the immune system [ 55 ]. In contrast to expensive genomic assays, TILs can be scored on routine diagnostic H&E sections, making it very attractive for clinical application.…”

Section: Gene Expression Profiles With Benefit From Rt As Focusmentioning

confidence: 99%

Individualising radiation therapy decisions in breast cancer patients based on tumour infiltrating lymphocytes and genomic biomarkers

et al. 2023

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Section: Gene Expression Profiles With Benefit From Rt As Focusmentioning

confidence: 99%

Individualising radiation therapy decisions in breast cancer patients based on tumour infiltrating lymphocytes and genomic biomarkers

et al. 2023

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“…Immune system is a radiation‐sensitive tissue in the body. Many studies have confirmed that ionizing radiation (IR) can induce immune damage in the system 26–28 . Localized 8.7 cGy over 10 days resulted in longstanding systemic lymphoid hypoplasia and low dose radiation could induce immune suppression 29,30 .…”

Section: Introductionmentioning

confidence: 99%

“…Many studies have confirmed that ionizing radiation (IR) can induce immune damage in the system. 26 , 27 , 28 Localized 8.7 cGy over 10 days resulted in longstanding systemic lymphoid hypoplasia and low dose radiation could induce immune suppression. 29 , 30 However, the mechanism is still unclear, and it is important to find a target that can evaluate the application value of radiation‐induced immune injury.…”

Section: Introductionmentioning

confidence: 99%

Deficiency of salt‐inducible kinase 2 (SIK2) promotes immune injury by inhibiting the maturation of lymphocytes

Zhu,

Li,

Wang

et al. 2023

MedComm

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Salt‐inducible kinase 2 (SIK2) belongs to the serine/threonine protein kinases of the AMPK/SNF1 family, which has important roles in cell cycle, tumor, melanogenesis, neuronal damage repair and apoptosis. Recent studies showed that SIK2 regulates the macrophage polarization to make a balance between inflammation and macrophage. Macrophage is critical to initiate immune regulation, however, whether SIK2 can be involved in immune regulation is not still well understood. Here, we revealed that the protein of SIK2 was highly expressed in thymus, spleen, lung, and brain. And SIK2 protein content increased in RAW264.7 and AHH1 cells with a time and dose‐dependent after‐ionizing radiation (IR). Inhibition of SIK2 could promote AHH1 cells apoptosis Moreover, we used the Cre‐LoxP system to construct the SIK2+/− mice, and the research on function suggested that the deficiency of SIK2 could promote the sensitivity of IR. The deficiency of SIK2 promoted the immune injury via inhibiting the maturation of T cells and B cells. Furthermore, the TCRβ rearrangement was inhibited by the deficiency of SIK2. Collectively, this study demonstrated that SIK2 provides an essential function of regulating immune injury, which will provide new ideas for the treatment of immune injury‐related diseases.

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Large institutional experience of early outcomes and dosimetric findings with postoperative stereotactic partial breast irradiation in breast cancer

Chang,

Lee,

Vicini

et al. 2024

Radiotherapy and Oncology

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Evidence for Persistent Radiation-Related Injury to the Immune System in Patients With Local Breast Cancer

Cited by 3 publications

References 16 publications

Individualising radiation therapy decisions in breast cancer patients based on tumour infiltrating lymphocytes and genomic biomarkers

Individualising radiation therapy decisions in breast cancer patients based on tumour infiltrating lymphocytes and genomic biomarkers

Deficiency of salt‐inducible kinase 2 (SIK2) promotes immune injury by inhibiting the maturation of lymphocytes

Large institutional experience of early outcomes and dosimetric findings with postoperative stereotactic partial breast irradiation in breast cancer

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