Evidence for Plastic Processes in Migraine with Aura: A Diffusion Weighted MRI Study

Szabó, Nikoletta; Faragó, Péter; Király, András; Veréb, Dániel; Csete, Gergő; Tóth, Eszter; Kocsis, Krisztián; Kincses, Bálint; Tuka, Bernadett; Párdutz, Árpád; Delia, S.; Tajti, János; Vécsei, László; Kincses, Zsigmond Tamás

doi:10.3389/fnana.2017.00138

Cited by 43 publications

(71 citation statements)

References 75 publications

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“…In line with our CM correlation results, Szabó et al, 2017 [10], obtained a trend showing increased FA in migraine with aura patients with respect to healthy controls. In this study, based on increased FA values, the authors hypothesised that repeated painful conditions or increased cortical excitability might cause maladaptive plastic changes in migraine with aura.…”

Section: Discussionsupporting

confidence: 91%

“…Previous whole-brain TBSS studies found white matter differences between migraine patients and healthy controls [6][7][8][9][10][11]52]. Most of these studies report decreased FA in migraine patients with respect to healthy controls, but one study showed increased FA in migraineurs with respect to healthy controls; in this study, Messina et al analysed paediatric patients [9], which could explain the difference.…”

Section: Discussionmentioning

confidence: 58%

“…Among its different modalities, diffusion MRI (dMRI) is particularly well suited for the analysis of possible white matter alterations in migraine. dMRI studies have shown changes affecting the white matter in migraineurs with respect to healthy controls; these changes were mainly observed in the corpus callosum [5][6][7][8][9][10][11], thalamus [7,8,12,13], thalamic radiation [7-9, 14, 15] and cingulate gyrus [9,10,[15][16][17].…”

Section: Introductionmentioning

confidence: 99%

“…Some studies using dMRI have focused on migraine with and without aura. Even though significant differences have been found [10,18], using MRI information it remains unclear whether migraine with and without aura area are actually two distinct entities, the manifestations of the same pathophysiological substrate on two different phenotypes [19,20], or even whether aura can be better defined as a migraine phase, but not a category such as chronic and episodic migraine [21].…”

Section: Introductionmentioning

confidence: 99%

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White matter changes in chronic and episodic migraine: a diffusion tensor imaging study

et al. 2020

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Background: White matter alterations have been observed in patients with migraine. However, no microstructural white matter alterations have been found particularly in episodic or chronic migraine patients, and there is limited research focused on the comparison between these two groups of migraine patients. Methods: Fifty-one healthy controls, 55 episodic migraine patients and 57 chronic migraine patients were recruited and underwent brain T1-weighted and diffusion-weighted MRI acquisition. Using Tract-Based Spatial Statistics (TBSS), fractional anisotropy, mean diffusivity, radial diffusivity and axial diffusivity were compared between the different groups. On the one hand, all migraine patients were compared against healthy controls. On the other hand, patients from each migraine group were compared between them and also against healthy controls. Correlation analysis between clinical features (duration of migraine in years, time from onset of chronic migraine in months, where applicable, and headache and migraine frequency, where applicable) and Diffusion Tensor Imaging measures was performed. Results: Fifty healthy controls, 54 episodic migraine and 56 chronic migraine patients were finally included in the analysis. Significant decreased axial diffusivity (p < .05 false discovery rate and by number of contrasts corrected) was found in chronic migraine compared to episodic migraine in 38 white matter regions from the Johns Hopkins University ICBM-DTI-81 White-Matter Atlas. Significant positive correlation was found between time from onset of chronic migraine and mean fractional anisotropy in the bilateral external capsule, and negative correlation between time from onset of chronic migraine and mean radial diffusivity in the bilateral external capsule. Conclusions: These findings suggest global white matter structural differences between episodic migraine and chronic migraine. Patients with chronic migraine could present axonal integrity impairment in the first months of chronic migraine with respect to episodic migraine patients. White matter changes after the onset of chronic migraine might reflect a set of maladaptive plastic changes.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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White matter changes in chronic and episodic migraine: a diffusion tensor imaging study

et al. 2020

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“…Up to now, white matter microstructural integrity showed no differences between the two sub-groups, or the studies did not separate the subgroups for investigation (Chong and Schwedt, 2015;Szabo et al, 2012). However, there are findings showing dissimilarities in the diffusion parameters between MWA and MWoA in the visual pathway (Granziera et al, 2006;Nikoletta Szabó, 2018). Furthermore, in our recent work, we found extensive disintegration of the white matter in migraine patients with aura, but not in patients without aura (Nikoletta Szabó, 2018).…”

Section: Imaging Markers Of Migrainementioning

confidence: 83%

Resting State FMRI Frequency Specific Alterations In Primary Headache Disorders

Faragó¹

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Our results revealed resting state fMRI changes in primary headache disorders compared to the healthy controls. The changes were found in the functional connectivity and also in the amplitude of fluctuation in separated frequency bands. Furthermore, the resulted areas strictly connected to the headache side in CH. The resulted areas could be the part of the "pain matrix". These results provide a deeper insight into the patomechanism of migraine and CH. Furthermore, these results help us to understand better their connection to the pain processing system.

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Multimodal fusion analysis of structural connectivity and gray matter morphology in migraine

Planchuelo‐Gómez

García‐Azorín

Peral

et al. 2020

Human Brain Mapping

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No specific migraine biomarkers have been found in single‐modality MRI studies. We aimed at establishing biomarkers for episodic and chronic migraine using diverse MRI modalities. We employed canonical correlation analysis and joint independent component analysis to find structural connectivity abnormalities that are related to gray matter morphometric alterations. The number of streamlines (trajectories of estimated fiber‐tracts from tractography) was employed as structural connectivity measure, while cortical curvature, thickness, surface area, and volume were used as gray matter parameters. These parameters were compared between 56 chronic and 54 episodic migraine patients, and 50 healthy controls. Cortical curvature alterations were associated with abnormalities in the streamline count in episodic migraine patients compared to controls, with higher curvature values in the frontal and temporal poles being related to a higher streamline count. Lower streamline count was found in migraine compared to controls in connections between cortical regions within each of the four lobes. Higher streamline count was found in migraine in connections between subcortical regions, the insula, and the cingulate and orbitofrontal cortex, and between the insula and the temporal region. The connections between the caudate nucleus and the orbitofrontal cortex presented worse connectivity in chronic compared to episodic migraine. The hippocampus was involved in connections with higher and lower number of streamlines in chronic migraine. Strengthening of structural networks involving pain processing and subcortical regions coexists in migraine with weakening of cortical networks within each lobe. The multimodal analysis offers a new insight about the association between brain structure and connectivity.

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Evidence for Plastic Processes in Migraine with Aura: A Diffusion Weighted MRI Study

Cited by 43 publications

References 75 publications

White matter changes in chronic and episodic migraine: a diffusion tensor imaging study

White matter changes in chronic and episodic migraine: a diffusion tensor imaging study

Resting State FMRI Frequency Specific Alterations In Primary Headache Disorders

Multimodal fusion analysis of structural connectivity and gray matter morphology in migraine

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