Evidence for Platelet Activation According To Some Platelet Indices in a Cohort of Type 2 Diabetic Mellitus Patients

Ogbuabor, Alphonsus Ogbonna; Onyia, Loius Nkiruka; Ohotu, Edwin Obiora

doi:10.36348/sjbr.2022.v07i11.004

Saudi J. Biomed. Res.

2022

DOI: 10.36348/sjbr.2022.v07i11.004

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Evidence for Platelet Activation According To Some Platelet Indices in a Cohort of Type 2 Diabetic Mellitus Patients

Alphonsus Ogbonna Ogbuabor¹,

Loius Nkiruka Onyia²,

Edwin Obiora Ohotu³

Abstract: Diabetes mellitus has over the years become a public health issue. It is a complex disease which is characterized by chronic hyperglycemia. The present study was designed to determine some platelet indices in Type 2 Diabetic Mellitus (T2DM) patients compared to non-diabetic controls. A total of 240 subjects comprising 120 T2DM (60 males and 60 females) aged 20-55 years and 120 apparently healthy age and gender-matched controls were recruited for the study. Blood samples (5.0ml) were collected from each subject… Show more

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Comparative evaluation of platelet indices in Preeclamptic and Non-Preeclamptic patients in the Enugu Metropolis

Obiorah¹,

Nneoma²,

Ogbonna³

2023

Open J Trop Med

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Preeclampsia (PE) is one of the most common causes of maternal mortality and morbidity. It complicates 5% - 6% of all pregnancies globally and up to 15% of pregnancies in Sub-Saharan Africa. The present study was designed to determine the values of platelet indices in preeclamptic patients compared to non-preeclamptic controls. A total of 70 patients comprising 35 preeclamptic cases and 35 non-preeclamptic controls aged 18-40 years were recruited for the study. Blood samples (3mls) were collected from patients for the estimation of platelet indices using the Mindray 530 BC automated hematology analyzer, Mindray, Japan. The data were analyzed by SPSS version 22 using T - test and Pearson correlation. The level of significance was set at p < 0.05 and the result was presented as mean + SD. The result revealed a significant increase in the MPV (13.5 + 0.18 vs. 09.4 + 0.20), PDW (16.2 + 0.037 vs. 06.0 + 0.19) and PLCR (38.0 + 1.19 vs. 26.2 + 1.19) between the preeclamptic patients and non-preeclamptic controls. There was a significant decrease in the PLT (174.1 + 15.5 vs. 231.1 + 15.05), PCT (1.9 + 0.14 vs. 3.3 + 0.75), and PLCC (60.7 + 3.24 vs. 69.4 + 3.17) for the preeclamptic cases compared to non-preeclamptic control. These findings may be useful in the management of the adverse outcomes of preeclampsia for the Enugu population.

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Comparative evaluation of platelet indices in Preeclamptic and Non-Preeclamptic patients in the Enugu Metropolis

Obiorah¹,

Nneoma²,

Ogbonna³

2023

Open J Trop Med

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Effect of a hospital-based maternal counseling guide on exclusive breastfeeding practices in Anambra State, Nigeria: A protocol for a cluster-randomized controlled trial (HOME Trial)

Maureen Ugonwa,

Chisom God’swill,

Chinazom Cynthia

et al. 2023

Open J Trop Med

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Background: Optimal breastfeeding is so critical that it could save the lives of over 820,000 children under the age of five years each year. For optimal growth, development, and health, the WHO recommends Exclusive Breastfeeding (EBF) in the first six months. To ensure nursing mothers breastfeed their children exclusively, they should also have access to skilled practical help to build mothers’ confidence and prevent or resolve breastfeeding problems. Interventions promoting optimal Infant and Young Child Feeding practices could prevent 19% of under-five deaths, and such intervention could improve nursing mothers’ understanding and practice of EBF. Objective: This trial is designed to formulate a hospital-based counseling guide on EBF, implement it, and determine its effect on improving EBF practice in Anambra State, Nigeria. Methods: The study is a cluster randomized controlled trial conducted in selected hospitals in Anambra State, Nigeria. Based on inclusion criteria, 12 hospitals that offer comprehensive ante-natal and post-natal clinic services and have a higher population of women assessing care in the ante- and post-natal clinics were selected for the study. Six hospitals each were randomized to either the intervention or the control arm. The intervention hospitals received the formulated hospital-based counseling guide and the hospital’s usual care, while the control hospitals received only the hospital’s usual care. Statistical analysis will be conducted using Statistical Package for Social Science (SPSS version 25). Descriptive statistics will be used to summarize and present demographic and clinical characteristics. Categorical variables will be expressed as frequencies or percentages and quantitative variables as means, standard deviations, median, and interquartile ranges. An intention-to-treat analysis will be conducted.

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Evidence for Platelet Activation According To Some Platelet Indices in a Cohort of Type 2 Diabetic Mellitus Patients

Cited by 2 publications

References 0 publications

Comparative evaluation of platelet indices in Preeclamptic and Non-Preeclamptic patients in the Enugu Metropolis

Comparative evaluation of platelet indices in Preeclamptic and Non-Preeclamptic patients in the Enugu Metropolis

Effect of a hospital-based maternal counseling guide on exclusive breastfeeding practices in Anambra State, Nigeria: A protocol for a cluster-randomized controlled trial (HOME Trial)

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