Evidence for Schizophrenia-Specific Pathophysiology of Nicotine Dependence

Ward, Heather Burrell; Beerman, Adam; Nawaz, Uzma; Halko, Mark A.; Janes, Amy C.; Moran, Lauren V.; Brady, Roscoe O.

doi:10.1016/j.biopsych.2021.02.889

Cited by 2 publications

(2 citation statements)

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“…This model considers that people may be more susceptible to a certain drug or class of drugs (or to compulsive video game use, for example), based on individual differences, and different mental disorders or symptoms, including endophenotypes, such as personality traits. It is well known that the administration of psychoactive substances do not have the same effects among different individuals [51,52]. One of the clearest examples is that stimulants calm down people with Attention-Deficit/Hyperactivity Disorder (ADHD), but not others, by correcting imbalances in dopamine and norepinephrine levels [53].…”

Section: From Molecules To Environmentmentioning

confidence: 99%

“…It is clear that the chronic use of any psychoactive (including addictive) substances can jeopardize various aspects of brain activity, like blood flow, neurotransmitter activity, structure, and functional connectivity, in ways that could either trigger or exacerbate the symptoms of a mental illness [9]. Additionally, it is hardly surprising to discover that unmet mental healthcare needs are closely linked to the consumption of psychoactive substances that can lead to a SUD [51,72]. This is consistent with the self-medication hypothesis, as revisited from a neurobiological perspective [73].…”

Section: From Molecules To Environmentmentioning

confidence: 99%

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Addictive and other mental disorders: a call for a standardized definition of dual disorders

Szerman

Torrens²,

Maldonado³

et al. 2022

Transl Psychiatry

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The persistent difficulty in conceptualizing the relationship between addictive and other mental disorders stands out among the many challenges faced by the field of Psychiatry. The different philosophies and schools of thought about, and the sheer complexity of these highly prevalent clinical conditions make progress inherently difficult, not to mention the profusion of competing and sometimes contradictory terms that unnecessarily exacerbate the challenge. The lack of a standardized term adds confusion, fuels stigma, and contributes to a “wrong door syndrome” that captures the difficulty of not only diagnosing but also treating addictive and other mental disorders in an integrated manner. The World Association on Dual Disorders (WADD) proposes the adoption of the term “Dual Disorder” which, while still arbitrary, would help harmonize various clinical and research efforts by rallying around a single, more accurate, and less stigmatizing designation.

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Section: From Molecules To Environmentmentioning

confidence: 99%