Evidence for sex differences in the loudness dependence of the auditory evoked potential in humans

Oliva, Jessica Lee; Leung, Sumie; Croft, Rodney J.; O’Neill, Barry V.; Stout, Julie C.; Nathan, Pradeep J.

doi:10.1002/hup.1187

Cited by 18 publications

(12 citation statements)

References 42 publications

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“…Furthermore, the sample in Gudlowski’s study included females and males. Even though some studies reported no gender effects [29], [40], [61], others have documented some effects on the LDAEP [62], [63], [64]. The study by Juckel et al (2008) [39] used comparable methodology to the present study and some results are in line with our findings, showing strong LDAEP in patients with negative symptoms among schizophrenic patients.…”

Section: Discussionsupporting

confidence: 90%

The Loudness Dependence of Auditory Evoked Potentials (LDAEP) as an Indicator of Serotonergic Dysfunction in Patients with Predominant Schizophrenic Negative Symptoms

et al. 2013

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Besides the influence of dopaminergic neurotransmission on negative symptoms in schizophrenia, there is evidence that alterations of serotonin (5-HT) system functioning also play a crucial role in the pathophysiology of these disabling symptoms. From post mortem and genetic studies on patients with negative symptoms a 5-HT dysfunction is documented. In addition atypical neuroleptics and some antidepressants improve negative symptoms via serotonergic action. So far no research has been done to directly clarify the association between the serotonergic functioning and the extent of negative symptoms. Therefore, we examined the status of brain 5-HT level in negative symptoms in schizophrenia by means of the loudness dependence of auditory evoked potentials (LDAEP). The LDAEP provides a well established and non-invasive in vivo marker of the central 5-HT activity. We investigated 13 patients with schizophrenia with predominant negative symptoms treated with atypical neuroleptics and 13 healthy age and gender matched controls with a 32-channel EEG. The LDAEP of the N1/P2 component was evaluated by dipole source analysis and single electrode estimation at Cz. Psychopathological parameters, nicotine use and medication were assessed to control for additional influencing factors. Schizophrenic patients showed significantly higher LDAEP in both hemispheres than controls. Furthermore, the LDAEP in the right hemisphere in patients was related to higher scores in scales assessing negative symptoms. A relationship with positive symptoms was not found. These data might suggest a diminished central serotonergic neurotransmission in patients with predominant negative symptoms.

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Section: Discussionsupporting

confidence: 90%

The Loudness Dependence of Auditory Evoked Potentials (LDAEP) as an Indicator of Serotonergic Dysfunction in Patients with Predominant Schizophrenic Negative Symptoms

et al. 2013

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“…In our ERP study, the OPS-C scores also did not vary by gender ( P = 0.359) (Table 1). Findings that the mean ASF slopes were higher for female students than male students for the N1 and N1/P2 ASF slopes corroborated a study of gender differences in the LDAEP by Oliva et al [26]. The authors reported that the mean N1/P2 slopes for female participants were higher than those for male participants ( P < 0.0001), suggesting that the LDAEP was modulated by gender associated differences in serotonin transmitters.…”

Section: Discussionsupporting

confidence: 82%

“…The amplitudes of N1, P2, and N1/P2 were analyzed in separate analyses of covariance (ANCOVA) with stimulus intensities (60, 70, 80, 90, and 100 dB) as within factor and group (high optimistic/pessimistic) as between factor, controlling for the effect of gender [26]. Reported results were restricted to effects involving the group factor and group-intensity interactions [8].…”

Section: Methodsmentioning

confidence: 99%

Enhanced Intensity Dependence as a Marker of Low Serotonergic Neurotransmission in High Optimistic College Students

Zhang

Yao

et al. 2013

BioMed Research International

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Positive psychology focuses were on the merits of individuals, such as optimism and positive attitude, and the subsequent cultivation of these virtues. Optimism or pessimism is a significant predictor of physical health outcomes. The present study examined whether optimism or pessimism is associated with the loudness dependence of auditory evoked potentials (LDAEP), a biological indicator of serotonergic neurotransmission, for the N1, P2, and N1/P2 peaks in college students. The amplitudes and amplitude-stimulus intensity function (ASF) slopes of the N1, P2, and N1/P2 peaks were determined in the 24 (10 males) high optimistic and 24 (14 males) high pessimistic individuals. Significantly higher P2 ASF slopes were found in the optimistic group relative to the pessimistic group. Concerning peaks and ASF slopes of N1 and N1/P2, no significant differences were observed. Our results suggest that the serotonergic neurotransmission of the high optimistic college students was inferior to that of the pessimistic ones. Further investigations are needed to provide sufficient support for our results.

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“…However, there was evidence that the LDAEP is modulated by gender potentially. Oliva and collegues reported that LDAEP for female healthy participants was stronger than that for male healthy participants [44]. There was contrary evidence that female depressed patients showed weaker LDAEP strength than male depressed patients [45].…”

Section: Discussionmentioning

confidence: 95%

“…To avoid the hormonal effects on LDAEP, LDAEP measurement was conducted during 2 nd to 5 th day after the beginning of menstruation for female subjects [23]. Each subject was seated in a comfortable chair in a sound-attenuated room.…”

Section: Methodsmentioning

confidence: 99%

Association between BDNF Gene Polymorphisms and Serotonergic Activity Using Loudness Dependence of Auditory Evoked Potentials in Healthy Subjects

Park

Lee

et al. 2013

PLoS ONE

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It has been proposed that the loudness dependence of auditory evoked potentials (LDAEP) would be a reliable indicator of central serotonin system activity in humans. Serotonin levels and turnover are also increased by brain-derived neurotrophic factor (BDNF). The aim of the present study was to determine whether there is an association between genetic polymorphisms of BDNF and the LDAEP in healthy Korean young adults. The cohort comprised 211 mentally and physically healthy subjects, all of whom were nonsmokers (111 males, 100 females; age: 20∼32 years). To avoid hormonal effects, the LDAEP was measured during days 2–5 after the beginning of menstruation for female subjects. In addition, BDNF polymorphisms (rs6265, rs2030324, and rs1491850) were genotyped. The strength of the LDAEP differed significantly among the BDNF genotype groups. Furthermore, the distribution of genotypic frequencies differed significantly between subjects with high and low LDAEPs. In particular, subjects with the Val/Met (A/G) genotype for rs6265, the T/T genotype for rs2030324, or the C/C genotype for rs1491850 had a higher LDAEP, indicating lower central serotonergic activity. A low LDAEP was more prevalent than a high LDAEP among those with the C-T haplotype (C genotype for rs2030424 and T genotype for rs1491850). Our results concur with previous findings on BDNF polymorphisms and serotonergic drug responses in psychiatric disorder patients. The present results suggest the possibility that BDNF polymorphisms and LDAEP patterns can predict altered serotonergic activity.

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Evidence for sex differences in the loudness dependence of the auditory evoked potential in humans

Abstract: These findings suggest that the LDAEP is modulated by sex potentially because of differences in serotonergic neurotransmission, and these differences may account for some of the inconsistent findings linking serotonin function and LDAEP.

Cited by 18 publications

References 42 publications

The Loudness Dependence of Auditory Evoked Potentials (LDAEP) as an Indicator of Serotonergic Dysfunction in Patients with Predominant Schizophrenic Negative Symptoms

The Loudness Dependence of Auditory Evoked Potentials (LDAEP) as an Indicator of Serotonergic Dysfunction in Patients with Predominant Schizophrenic Negative Symptoms

Enhanced Intensity Dependence as a Marker of Low Serotonergic Neurotransmission in High Optimistic College Students

Association between BDNF Gene Polymorphisms and Serotonergic Activity Using Loudness Dependence of Auditory Evoked Potentials in Healthy Subjects

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