Evidence for silver in wound care – meta‐analysis of clinical studies from 2000–2015

Dissemond, Joachim; Böttrich, Johannes Georg; Braunwarth, Horst; Hilt, Jörg; Wilken, Patricia; Münter, Karl-Christian

doi:10.1111/ddg.13233

Cited by 38 publications

(47 citation statements)

References 48 publications

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“…Silver has been shown to have an antibacterial effect, and topical silver‐containing treatments (creams, dressings, etc) are widely used for IDFUs. While silver compounds may offer some benefits in ulcer healing, there is little evidence (including from several systematic reviews) to support their effectiveness in treating or preventing ulcer infection . Several small studies have, however, demonstrated anti‐infective benefits for some antiseptic agents (eg, cadexomer iodine and hypochlorous solutions) in infected DFUs.…”

Section: Treatmentmentioning

confidence: 99%

“…To specifically address infection in a diabetic foot ulcer, a) do not use adjunctive granulocyte colony stimulating factor treat- 178 there is little evidence (including from several systematic reviews) to support their effectiveness in treating or preventing ulcer infection. 179 Several small studies have, however, demonstrated anti-infective benefits for some antiseptic agents (eg, cadexomer iodine and hypochlorous solutions) in infected DFUs.…”

Section: Recommendation 27mentioning

confidence: 99%

See 1 more Smart Citation

Guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2019 update)

Lipsky

Senneville

Abbas

et al. 2020

Diabetes Metabolism Res

548

729

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The International Working Group on the Diabetic Foot (IWGDF) has published evidence‐based guidelines on the prevention and management of diabetic foot disease since 1999. This guideline is on the diagnosis and treatment of foot infection in persons with diabetes and updates the 2015 IWGDF infection guideline. On the basis of patient, intervention, comparison, outcomes (PICOs) developed by the infection committee, in conjunction with internal and external reviewers and consultants, and on systematic reviews the committee conducted on the diagnosis of infection (new) and treatment of infection (updated from 2015), we offer 27 recommendations. These cover various aspects of diagnosing soft tissue and bone infection, including the classification scheme for diagnosing infection and its severity. Of note, we have updated this scheme for the first time since we developed it 15 years ago. We also review the microbiology of diabetic foot infections, including how to collect samples and to process them to identify causative pathogens. Finally, we discuss the approach to treating diabetic foot infections, including selecting appropriate empiric and definitive antimicrobial therapy for soft tissue and for bone infections, when and how to approach surgical treatment, and which adjunctive treatments we think are or are not useful for the infectious aspects of diabetic foot problems. For this version of the guideline, we also updated four tables and one figure from the 2016 guideline. We think that following the principles of diagnosing and treating diabetic foot infections outlined in this guideline can help clinicians to provide better care for these patients.

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Section: Treatmentmentioning

confidence: 99%

Section: Recommendation 27mentioning

confidence: 99%

Guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2019 update)

Lipsky

Senneville

Abbas

et al. 2020

Diabetes Metabolism Res

548

729

View full text Add to dashboard Cite

show abstract

“…A meta-analysis of 157 clinical studies published from 2000 to 2015 concluded that the evidence base for silver in wound management was significantly more favorable than commonly perceived in the clinical community, with evidence suggesting that the use of silver in wound management is also costeffective and improves the patient quality of life. [26] Amid silver-based antimicrobials, silver NPs are broadspectrum bactericidal and virucidal species. [27] Furthermore, as shown for instance by the AgNPs capped with mercaptoethane sulfonate targeting the herpes virus, [10] they can be tailed to target specific microorganisms by surface functionalization.…”

Section: Advancing Ag-based Antimicrobials and Antiviralsmentioning

confidence: 99%

New Antivirals and Antibacterials Based on Silver Nanoparticles

2020

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The rediscovery of the medical uses of silver provides another noticeable example, this time at the interface of chemistry and medicine, of the real (and nonlinear) progress of scientific research. Several new silver‐based antimicrobial products have thus been commercialized in the last two decades. Next‐generation antibacterials and antivirals of broad scope, low toxicity and affordable cost, we argue in this study, will be based on microencapsulated Ag nanoparticles.

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“…Signs of wound infection include pus, spreading redness, increased pain or swelling, and fever a break in the skin (a wound) shows signs of infection. They includes: infected cuts, scrapes, sutured wounds, puncture wounds and animal bites; most dirty wounds become infected 24 to 72 hours later [21].Caring for child's wound is important to promote healing, avoid infection and minimise scarring. Different types of wounds require different dressing products and care.…”

Section: Discussionmentioning

confidence: 99%

“…The treatment of choice remains the penicillinase-resistant penicillins such as cloxacillin and flucloxacillin. In adults, current treatment recommendations are cefazolin or ocloxacillin [25]. Il the elderly many factors may influence the probability of developing an surgical skin infection after a surgical intervention.…”

Section: Discussionmentioning

confidence: 99%

Children vs elderly in orthopedic surgery site of infection. Are there difference? Experience of a high volume plastic surgeon consultant.

Franzese¹,

Conte²,

Gagliardo³

et al. 2020

Acta Med Sal

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Introduction: Prevention of surgical site infection in surgery and bone trauma has some hallmarks not shared with other surgical disciplines. The surgeon is not always able to open the pathogen and a key to correct therapy. The aim of our work is to verify if there are differences between pathogens, and treatment between the two groups most susceptible to skin infections by means of synthesis such as children and the elderly. Materials and Methods: From January 2011 to december 2018, we perform 3189 consultancies in various departments of orthopedics and traumatology. From the exclusion criteria we recruited 168 patients with superficial infection of the surgical site after orthopedic surgery. A group represented by children (under 12 years old) and a group of older people over 65. The evaluation criteria between the two groups were: the infectious bacterial flora; the type of antibiotic, the duration of antibiotic therapy; the type of medications used in the post-operative period, the complications.Results:The results showed that elderly patients are more likely to be bacterial superinfection due to poor hygiene. Therapy in children is shorter and has minor complications. Proper management of the surgical site showed a rapid resolution of the infection in both groups. Conclusion: The correct management and hygiene of the surgical site allows its rapid recovery from infection. The plastic surgeon management of the fracture site infection can be a winning weapon in the treatment of this problem both in the child and in the elderly.

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Evidence for silver in wound care – meta‐analysis of clinical studies from 2000–2015

Cited by 38 publications

References 48 publications

Guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2019 update)

Guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2019 update)

New Antivirals and Antibacterials Based on Silver Nanoparticles

Children vs elderly in orthopedic surgery site of infection. Are there difference? Experience of a high volume plastic surgeon consultant.

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