Evidence for the involvement of 5-HT2A receptors in mild mesenteric ischemia/reperfusion dysfunctions in mice

Bertoni, Simona; Ghizzardi, Paola; Cattaruzza, Fiore; Ballabeni, Vigilio; Impicciatore, M; Tognolini, Massimiliano; Lagrasta, Costanza; Barocelli, Elisabetta

doi:10.1016/j.phrs.2007.10.004

Cited by 11 publications

(4 citation statements)

References 36 publications

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“…These observations provided the background for our hypothesis that μORs activation might attenuate the inflammatory response induced by intestinal I/R. To test our hypothesis, we used a model of mild mesenteric ischemia developed in mice by reversible occlusion of the superior mesenteric artery (SMA) for 45 min, followed by 5 hr of reperfusion (Ballabeni et al,2002; Calcina et al,2005; Cattaruzza et al,2006; Barocelli et al,2006; Bertoni et al,2007). The aim of our study was to investigate the effect of exogenous administration of a selective μOR agonist in the presence or in the absence of a selective μOR antagonist on intestinal injury induced by I/R in mice.…”

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confidence: 99%

Protective role of μ opioid receptor activation in intestinal inflammation induced by mesenteric ischemia/reperfusion in mice

Saccani

Anselmi

Jaramillo

et al. 2012

J of Neuroscience Research

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Intestinal ischemia is a clinical emergency with high morbidity and mortality. We investigated whether activation of µ opioid receptor (µOR) protects from the inflammation induced by intestinal ischemia and reperfusion (I/R) in mice. Ischemia was induced by occlusion of the superior mesenteric artery (45 min) and followed by reperfusion (5 hours). Sham Operated (SO) and normal (N) mice served as controls. Each group received subcutaneously: (1) saline solution; (2) the µOR selective agonist, [D-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin (DAMGO) (0.01 mg.kg−1); (3) DAMGO and the selective µOR antagonist [H-D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2] (CTAP) (0.1 mg.kg−1) or (4) CTAP alone. I/R induced intestinal inflammation as indicated by histological damage and the significant increase in myeloperoxidase (MPO) activity, index of tissue neutrophil accumulation. TNF-α and IL-10 mRNA levels were also increased in I/R mice compared to SO. DAMGO significantly reduced tissue damage, MPO activity and TNF-α mRNA levels in I/R and these effects were reversed by CTAP. By contrast, DAMGO did not modify IL-10 mRNA levels and gastrointestinal transit. DAMGO effects are receptor-mediated and are likely due to activation of peripheral µORs since it does not readily cross the blood brain barrier. These findings suggest that activation of peripheral µOR protects from the inflammatory response induced by I/R through a pathway involving the pro-inflammatory cytokine, TNF-α. Reduction of acute inflammation might prevent I/R complications, including motility impairment, which develop at a later stage of reperfusion and are likely due to inflammatory cell infiltrates.

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confidence: 99%

Protective role of μ opioid receptor activation in intestinal inflammation induced by mesenteric ischemia/reperfusion in mice

Saccani

Anselmi

Jaramillo

et al. 2012

J of Neuroscience Research

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“…Potentiation of serotonin function with serotonin reuptake inhibitors could ameliorate mucosal damage in mice model of intestinal ischemia (Tackett et al, 2019). While, it was disclosed that 5HT2A partly mediates the injury in intestinal ischemia (Bertoni et al, 2007). These controversial findings demonstrated that the effect of each subtype of 5HT receptor must be investigated separately.…”

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confidence: 99%

Beyond its anti‐migraine properties, sumatriptan is an anti‐inflammatory agent: A systematic review

Ala

Ghasemi

Jafari

et al. 2021

Drug Development Research

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Sumatriptan is the first available medication from triptans family that was approved by the U.S. Food and Drug Administration for migraine attacks and cluster headaches in 1991. Most of its action is mediated by selective 5‐HT1B/1D receptor agonism. Recent investigations raised the possibility of repositioning of this drug to other indications beyond migraine, as increasing evidence suggests for an anti‐inflammatory property of sumatriptan. We performed a literature search using PubMed, Web of Science, Scopus, and Google Scholar using “inflammation AND sumatriptan” or “inflammation AND 5HT1B/D” as the keywords. Then, articles were screened for their relevance and those directly discussing the correlation between inflammation and sumatriptan or 5HT1B/D were included. Total references reviewed or inclusion/exclusion were 340 retrieved full‐text articles (n = 340), then based on critical assessment 66 of them were included in this systematic review. Our literature review indicates that at low doses, sumatriptan can reduce inflammatory markers (e.g., interleukin‐1β, tumor necrosis factor‐α, and nuclear factor‐κB), affects caspases and changes cells lifespan. Additionally, nitric oxide synthase and nitric oxide signaling seem to be regulated by this drug. It also inhibits the release of calcitonin gene‐related peptide. Sumatriptan protects against many inflammatory conditions including cardiac and mesenteric ischemia/reperfusion, skin flap, pruritus, peripheral, and central nervous system injuries such as spinal cord injury, testicular torsion‐detorsion, oral mucositis, and other experimental models. Considering the safety and potency of low dose sumatriptan compared to corticosteroids and other immunosuppressive medications, it is worth to take advantage of sumatriptan in inflammatory conditions.

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“…Remarkably, zacopride as an agonist of I K1 channels, besides increasing I K1 currents, also has an effect on 5-HT receptors which have been potentially linked to I/R injury. 19,20 In addition to blocking I K1 currents, BaCl 2 also blocks IK ATP . So, we cannot assert that zacopride improves protection of IPO, just activation of I K1 channels and BaCl 2 impairs the protection of IPO merely induced by blocking I K1 channels.…”

Section: Discussionmentioning

confidence: 99%

Agonist of inward rectifier K⁺ channels enhances the protection of ischemic postconditioning in isolated rat hearts

2014

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Evidence for the involvement of 5-HT2A receptors in mild mesenteric ischemia/reperfusion dysfunctions in mice

Cited by 11 publications

References 36 publications

Protective role of μ opioid receptor activation in intestinal inflammation induced by mesenteric ischemia/reperfusion in mice

Protective role of μ opioid receptor activation in intestinal inflammation induced by mesenteric ischemia/reperfusion in mice

Beyond its anti‐migraine properties, sumatriptan is an anti‐inflammatory agent: A systematic review

Agonist of inward rectifier K⁺ channels enhances the protection of ischemic postconditioning in isolated rat hearts

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Evidence for the involvement of 5-HT2A receptors in mild mesenteric ischemia/reperfusion dysfunctions in mice

Cited by 11 publications

References 36 publications

Protective role of μ opioid receptor activation in intestinal inflammation induced by mesenteric ischemia/reperfusion in mice

Protective role of μ opioid receptor activation in intestinal inflammation induced by mesenteric ischemia/reperfusion in mice

Beyond its anti‐migraine properties, sumatriptan is an anti‐inflammatory agent: A systematic review

Agonist of inward rectifier K+ channels enhances the protection of ischemic postconditioning in isolated rat hearts

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Agonist of inward rectifier K⁺ channels enhances the protection of ischemic postconditioning in isolated rat hearts