Evidence for the involvement of a GABAergic mechanism in the effectiveness of natural and synthetically modified incensole derivatives in neuropharmacological disorders: A computational and pharmacological approach

Al‐Harrasi, Ahmed; Khan, Ajmal; Rehman, Najeeb Ur; Al-Shidhani, Sulaiman; Khan, Imran; Halim, Sobia Ahsan; Al‐Rawahi, Ahmed; Hussain, Javid; Csük, René

doi:10.1016/j.phytochem.2019.04.007

Cited by 9 publications

(5 citation statements)

References 47 publications

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“…The following data indicate the included number of publications with adequate reporting of lighting from the starting n = 105 per behavioral test: the Light/Dark Box Test [ n = 61; 62.25% (Banaskowski et al, 2015 ; Bentea et al, 2015 ; Bertolus et al, 2015 ; Kalouda and Pitsikas, 2015 ; Liu et al, 2015 ; Quines et al, 2015 ; Sauce et al, 2015 ; Skupio et al, 2015 ; Thompson et al, 2015 ; Yu et al, 2015 ; Zhang C. et al, 2015 ; Zhang et al, 2016 ; Acevedo et al, 2016 ; Christensen et al, 2016 ; Diaz et al, 2016 ; Farajdokht et al, 2016 ; Fedotova et al, 2016 ; Fernandez et al, 2016 ; Hicks J. A. et al, 2016 ; Labots et al, 2016 ; Miranda-Morales and Pautassi, 2016 ; Salari et al, 2016 ; Socala and Wlaz, 2016 ; Vogt et al, 2016 ; Bahi, 2017a ; Benoit et al, 2017 ; Borbely et al, 2017 ; Chandra Sekhar et al, 2017 ; Domonkos et al, 2017 ; Khalil and Fendt, 2017 ; Lee et al, 2017 ; Makinson et al, 2017 ; Orfanidou et al, 2017 ; Rogers et al, 2017 ; Salari and Amani, 2017 ; Sanna et al, 2017 ; Sirohi et al, 2017 ; Amodeo et al, 2018 ; Cazuza et al, 2018 ; Dong et al, 2018 ; Ferreira de Araújo et al, 2018 ; Garcia-Gutierrez et al, 2018 ; Heinla et al, 2018 ; Keenan et al, 2018 ; Mahmoudi et al, 2018 ; Morley-Fletcher et al, 2018 ; Van Camp et al, 2018 ; Wille-Bille et al, 2018 ; Zhang and Yao, 2018 ; Al-Harrasi et al, 2019 ; Bahi and Dreyer, 2019 ; Borrow et al, 2019 ...…”

Section: Methodsmentioning

confidence: 99%

Under or Absent Reporting of Light Stimuli in Testing of Anxiety-Like Behaviors in Rodents: The Need for Standardization

Neuwirth

Verrengia

Harikinish-Murrary

et al. 2022

Front. Mol. Neurosci.

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Behavioral neuroscience tests such as the Light/Dark Test, the Open Field Test, the Elevated Plus Maze Test, and the Three Chamber Social Interaction Test have become both essential and widely used behavioral tests for transgenic and pre-clinical models for drug screening and testing. However, as fast as the field has evolved and the contemporaneous involvement of technology, little assessment of the literature has been done to ensure that these behavioral neuroscience tests that are crucial to pre-clinical testing have well-controlled ethological motivation by the use of lighting (i.e., Lux). In the present review paper, N = 420 manuscripts were examined from 2015 to 2019 as a sample set (i.e., n = ~20–22 publications per year) and it was found that only a meager n = 50 publications (i.e., 11.9% of the publications sampled) met the criteria for proper anxiogenic and anxiolytic Lux reported. These findings illustrate a serious concern that behavioral neuroscience papers are not being vetted properly at the journal review level and are being released into the literature and public domain making it difficult to assess the quality of the science being reported. This creates a real need for standardizing the use of Lux in all publications on behavioral neuroscience techniques within the field to ensure that contributions are meaningful, avoid unnecessary duplication, and ultimately would serve to create a more efficient process within the pre-clinical screening/testing for drugs that serve as anxiolytic compounds that would prove more useful than what prior decades of work have produced. It is suggested that improving the standardization of the use and reporting of Lux in behavioral neuroscience tests and the standardization of peer-review processes overseeing the proper documentation of these methodological approaches in manuscripts could serve to advance pre-clinical testing for effective anxiolytic drugs. This report serves to highlight this concern and proposes strategies to proactively remedy them as the field moves forward for decades to come.

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Section: Methodsmentioning

confidence: 99%

Under or Absent Reporting of Light Stimuli in Testing of Anxiety-Like Behaviors in Rodents: The Need for Standardization

Neuwirth

Verrengia

Harikinish-Murrary

et al. 2022

Front. Mol. Neurosci.

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“…General Experimental Procedure. 1 H and 13 C NMR spectroscopic data were recorded on a Bruker Avance III HD 600 MHz NMR spectrometer equipped with a QCI 5 mm Cryoprobe and a SampleJet automated sample changer (Bruker BioSpin). Chemical shifts (δ) were measured in parts per million using the CDCl 3 signal as an internal standard for all spectra (δ H 7.27; δ C 77.2), and coupling constants (J) are reported in hertz.…”

Section: ■ Methodsmentioning

confidence: 99%

“…17−20 Incensole derivatives isolated from Boswellia papyrifera have demonstrated antiseizure activity in an acute mouse seizure assay, which was associated with γ-aminobutyric acid (GABA) receptor modulation. 13 Additionally, an extract of another Boswellia species (B. thurifera) was also found to modulate GABA receptor activity. 21 In this case the active principle was identified as the abietane diterpenoid dehydroabietic acid.…”

Section: ■ Introductionmentioning

confidence: 99%

“…6−8 Today, Boswellia extracts are commonly sold as a dietary supplement for their anti-inflammatory and antiarthritis properties, which are supported by clinical evidence. 9−11 Pharmacological studies have also confirmed the antitumor and psychoactive activities of frankincense, 7,12,13 and its essential oil has been cited for its relaxant properties in aromatherapy 14 and anecdotally reported for seizure relief. 15,16 Actually, several reports have described the antiseizure property of Boswellia serrata extracts in rodent epilepsy models, however, with no clear link of activity with pure active principle(s).…”

Section: ■ Introductionmentioning

confidence: 99%

“…Frankincense, which in French words means “pure incense”, is the oleogum resin of Boswellia trees (Burseraceae) of which the species are native to the Middle East, East Africa, and India . This resin has thousands of years of history and was used in ancient Egypt (1500 BC) and India (since the first century AD) for spiritual ceremonies but also for its medicinal properties to treat digestive, rheumatic, inflammatory, and CNS-related disorders. − Today, Boswellia extracts are commonly sold as a dietary supplement for their anti-inflammatory and antiarthritis properties, which are supported by clinical evidence. − Pharmacological studies have also confirmed the antitumor and psychoactive activities of frankincense, ,, and its essential oil has been cited for its relaxant properties in aromatherapy and anecdotally reported for seizure relief. , Actually, several reports have described the antiseizure property of Boswellia serrata extracts in rodent epilepsy models, however, with no clear link of activity with pure active principle(s). − Incensole derivatives isolated from Boswellia papyrifera have demonstrated antiseizure activity in an acute mouse seizure assay, which was associated with γ-aminobutyric acid (GABA) receptor modulation . Additionally, an extract of another Boswellia species ( B. thurifera ) was also found to modulate GABA receptor activity .…”

Section: Introductionmentioning

confidence: 99%

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Identification of Potential Antiseizure Agents in Boswellia sacra using In Vivo Zebrafish and Mouse Epilepsy Models

Brillatz

Jacmin

Queiroz

et al. 2021

ACS Chem. Neurosci.

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The resin of the tree Boswellia sacra Flueck. (synonym: B. carterii; Burseraceae), also known as "frankincense", is a traditional remedy used for central nervous system disorders in East Africa. Here we report the evaluation of its antiseizure activity in zebrafish and mouse epilepsy models to identify novel antiseizure compounds. The resin was extracted by solvents of increasing polarity. The hexane extract demonstrated the strongest antiseizure activity and was therefore subjected to bioactivityguided isolation, which leaded to the isolation of eight terpene derivatives. A new prenylbicyclogermacrene derivative (2) was isolated along with seven other compounds (1, 3−8). Among them, the triterpene β-boswellic acid (5) showed the strongest activity and reduced 90% of pentylenetetrazole (PTZ)-induced seizures at 100 μg/mL. In parallel to B. sacra, a commercial extract of Boswellia serrata was also evaluated and showed moderate bioactivity (45% reduction at 30 μg/mL). The extract of B. serrata was subjected to targeted isolation of other boswellic acid derivatives (9−13), which were evaluated for antiseizure activity in comparison with 5. In the whole series, β-boswellic acid (5) was the most active (60% reduction at 200 μM), and its potency was also confirmed with its purchased standard (S5). Pure nanoparticles of S5 and a commercially formulated extract of B. serrata were tested in a PTZ-kindling mouse seizure model. This notably revealed that the S5 administration reduced seizures by 50% in this mouse model, which was consistent with its detection and quantification in plasma and brain samples. This study and the preclinical evaluation performed indicate that β-boswellic acid, common to various species of Boswellia, has some potential as an antiseizure agent.

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Incensole derivatives from frankincense: Isolation, enhancement, synthetic modification, and a plausible mechanism of their anti-depression activity

Rehman

Al-Shidhani

Khan

et al. 2022

Bioorganic Chemistry

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Evidence for the involvement of a GABAergic mechanism in the effectiveness of natural and synthetically modified incensole derivatives in neuropharmacological disorders: A computational and pharmacological approach

Cited by 9 publications

References 47 publications

Under or Absent Reporting of Light Stimuli in Testing of Anxiety-Like Behaviors in Rodents: The Need for Standardization

Under or Absent Reporting of Light Stimuli in Testing of Anxiety-Like Behaviors in Rodents: The Need for Standardization

Identification of Potential Antiseizure Agents in Boswellia sacra using In Vivo Zebrafish and Mouse Epilepsy Models

Incensole derivatives from frankincense: Isolation, enhancement, synthetic modification, and a plausible mechanism of their anti-depression activity

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