Evidence for the involvement of human polymorphonuclear leucocyte mannose‐like receptors in the phagocytosis of <i>Escherichia coli</i>

Rottini, G; Cian, Franca; Soranzo, Maria Rosa; Albrigo, Rita; Patriarca, Pierluigi

doi:10.1016/0014-5793(79)80636-5

Cited by 40 publications

(16 citation statements)

References 15 publications

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“…Type 1 fimbriae are bacterial lectins, that are associated with increased adherence of the bacteria to different kinds of epithelial cells [1], phagocytes [2][3][4] and mucus [5]. The monosaccharide D-mannose inhibits adhesion mediated by type 1 fimbriae [6] suggesting that mannose residues on eukaryotic cell surfaces serve as receptor molecules [7].…”

Section: Introductionmentioning

confidence: 99%

The mannose-specific lectin activity of Escherichia coli type 1 fimbriae assayed by agglutination of glycolipid-containing liposomes, erythrocytes, and yeast cells and hydrophobic interaction chromatography

Öhman¹

1982

FEMS Microbiology Letters

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Section: Introductionmentioning

confidence: 99%

The mannose-specific lectin activity of Escherichia coli type 1 fimbriae assayed by agglutination of glycolipid-containing liposomes, erythrocytes, and yeast cells and hydrophobic interaction chromatography

Öhman¹

1982

FEMS Microbiology Letters

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“…The existence of receptor activity for D-mannose has been demonstrated for rat and mouse alveolar macrophage (31,32) and for human polymorphonuclear leukocytes (33). However, the rate of uptake by mouse peritoneal macrophage of aminomannose vesicles is much greater than the rate of uptake of mannose vesicles.…”

Section: Discussionmentioning

confidence: 99%

Phagocytosis of carbohydrate-modified phospholipid vesicles by macrophage.

Wu¹,

Tin²,

Baldeschwieler³

1981

Proc. Natl. Acad. Sci. U.S.A.

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Modification of the surface of distearoyl phosphatidylcholine vesicles with synthetic glycolipids dramatically affects the rate of uptake of these vesicles by mouse peritoneal macrophage. The high rate of uptake of 6-aminomannose-modified vesicles is effectively inhibited by cytochalasin B and chloroquine but not by colchicine, indicating that the mechanism of vesicle uptake is phagocytosis. Other modified vesicles appear to have some effect on the rate of uptake of 6-aminomannose-modified vesicles suggesting that the various vesicle types compete for the same initial binding sites. Analysis of 6-aminomannose-modified vesicles by y-ray perturbed angular correlation spectroscopy shows that the rotational correlation time of the encapsulated "'In3' does not change when the vesicles associate with macrophage. This result is consistent with transmission electron microscopy, which indicates that the aminomannose-modified vesicles remain intact after phagocytosis as aggregates of fused and intact vesicles surrounded by a single bilayer membrane structure.There is a growing body of evidence that carbohydrate cell-sur, face determinants play a significant role in intercellular recognition processes. Examples of mammalian carbohydrate recognition systems include (i) the receptor for galactose-terminated glycoproteins found in hepatocytes (1, 2), (ii) the receptor for 6-phosphomannosyl-containing glycoproteins found in fibroblasts (3, 4), and (iii) the receptor for mannose-terminated glycoproteins found in macrophage and polymorphonuclear leukocytes of the reticuloendothelial system (5-7). The existence of these receptors suggests that it should be possible to control the tissue distribution and cellular uptake of phospholipid vesicles by attaching appropriate carbohydrate determinants to the vesicle surface (8)(9)(10)(11).The modification of the surface of distearoyl phosphatidylcholine vesicles with particular synthetic glycolipids has been shown to affect dramatically the tissue distribution and stability ofthese vesicles in mice (12,13). The use ofvesicles loaded with "'In enables the structural integrity of the vesicles to be determined in vivo by y-ray perturbed angular correlation (PAC) spectroscopy and the tissue distribution to be determined by standard gamma-counting techniques (14-16). After intravenous injection, vesicles modified with 6-aminomannose derivatives of cholesterol produced initial retention ofhigh levels of intact vesicles in the lung, followed by concentration of intact vesicles in the liver and spleen. These modified vesicles concentrated in the axillary spaces associated with aggregates of polymorphonuclear leukocytes and macrophage when administered subcutaneously.The unusual tissue distributions and long-lifetimes observed in vivo for aminomannose-modified vesicles must depend in a complex way on interactions of these vesicles with serum components and specific cell types. To establish a better basis for understanding the remarkably stereospecific mechanisms for recognition and trans...

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“…suggested the presence of a lectin-like receptor on rat Kupffer cell membrane which binds neuraminidase-treated homologous red blood cells. Ful.thermore, Rottini et al (10) presented evidence for the involvement of human polymorphonuclear leucocyte mannose-like receptors in the phagocytesis of Escherichia coli. These results raise the possibility that some lectin-or sugar-like receptor might be responsible for the phagocytosis of chicken thymocytes.…”

Section: Discussionmentioning

confidence: 99%

Recognition of Heterologous Cells by Macrophages

Sugimoto

Sano

Enomoto

et al. 1980

Microbiology and Immunology

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Mouse and guinea pig macrophages cultured in vitro actively phagocytize non-opsonized thymocytes from certain heterologous animals including chickens, as shown in the accompanying paper (11). The present study was undertaken to investigate the mechanism of this phenomenon, using the phagocytosis of chicken thymocytes (c-thymocytes) by mouse and guinea pig macrophages.The involvement in this phenomenon of natural IgG passively adsorbed in situ to macrophages was excluded, since the phagocytosis of c-thymocytes was not significantly affected by the treatment of macrophages with homologous IgG or rabbit anti-sera directed toward homologous IgG. The involvement of lectin-or sugar-like receptors seems also to be unlikely, since various glycoproteins showed no significant effect. c-Thymocytes treated with normal mouse serum (NMS) but not with heat-inactivated NMS were strongly stained with goat anti-mouse C3 by an indirect immunofluorescent technique, and became extremely vulnerable to adherence to and phagocytosis by mouse macrophages, suggesting that cthymocytes are an activator of the alternative pathway of mouse complement. These results as a whole raise the possibility that mouse and guinea pig macrophages can phagocytize c-thymocytes by recognizing their activating surfaces of the alternative complement pathway without the participation of exogenously added IgG or complement, as proposed by others in the phagocytosis of rabbit and mouse red blood cells by human monocytes.In the accompanying paper (11) we have reported that mouse, rat, and guinea pig macrophages are able to discriminate intact thymocytes of certain heterologous animals from those of homologous origin, culminating in phagocytizing of these heterologous cells. The purpose of the present study is to investigate the mechanism of this phenomenon, using the phagocytosis of chicken thymocytes (c-thymocytes) by mouse and guinea pig macrophages.

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Evidence for the involvement of human polymorphonuclear leucocyte mannose‐like receptors in the phagocytosis of Escherichia coli

Cited by 40 publications

References 15 publications

The mannose-specific lectin activity of Escherichia coli type 1 fimbriae assayed by agglutination of glycolipid-containing liposomes, erythrocytes, and yeast cells and hydrophobic interaction chromatography

The mannose-specific lectin activity of Escherichia coli type 1 fimbriae assayed by agglutination of glycolipid-containing liposomes, erythrocytes, and yeast cells and hydrophobic interaction chromatography

Phagocytosis of carbohydrate-modified phospholipid vesicles by macrophage.

Recognition of Heterologous Cells by Macrophages

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