Evidence for the involvement of ionotropic glutamatergic receptors on the antinociceptive effect of (−)-linalool in mice

Batista, P.; Werner, Maria Fernanda de Paula; Oliveira, Erica Carvalho; Burgos, Leonel; Pereira, Patrı́cia; Brum, Lucimar Filot da Silva; Santos, Adair R.S.

doi:10.1016/j.neulet.2008.05.092

Cited by 104 publications

(84 citation statements)

References 29 publications

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“…Beirith et al (2002) described that the nociceptive response induced by glutamate appears to involve peripheral, spinal and supraspinal sites of action and it is greatly mediated by both NMDA and non-NMDA receptors. In this regard, Batista et al (2008) demonstrated that antinociceptive effect of LIN . The LEO and linalool block the synaptic-evoked field response on dentate gyrus.…”

Section: Discussionmentioning

confidence: 90%

“…Ocimum basilicum L. essential oil is rich in monoterpenes, such as δ-cadinol (10.2%), estragole (22.6%), and linalool (47.3%) (Mazutti et al, 2006 (Blank et al, 2007). (−)-Linalool is one natural enantiomer monoterpene compound of many essential oils, which is known to exhibit several biological activities such as CNS depressant, antinociceptive, anxiolytic and anticonvulsant (Peana et al, 2002;Peana et al, 2006;Kamatou & Viljoen, 2008;Batista et al, 2008). Until now, no data exists about the possible orofacial antinociception effect of (-)-linalool and O. basilicum leaf essential oil (LEO).…”

Section: Introductionmentioning

confidence: 99%

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Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach

Venâncio¹,

Marchioro²,

Estavam³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The present study investigated the antinociceptive effects of Ocimum basilicum L. (Lamiaceae) leaf essential oil (LEO) and (-)-linalool (LIN) in formalin (2%)-, glutamate (25 μM)-and capsaicin (2.5 µg)-induced orofacial nociception models in mice. The involvement of these substances was further evaluated on the neuronal excitability of the hippocampal dentate gyrus. Male mice (n=8/group) were pretreated separately with LEO and by LIN (50, 100, and 200 mg/kg, i.p.), morphine (5 mg/kg, i.p.) and vehicle (saline + Tween 80 0.2%), before injection of nociceptive agent into the right upper lip (perinasal area). The LEO and LIN reduced the nociceptive face-rubbing behaviour in both phases on formalin test. LEO and LIN, at high doses, produced significantly antinociceptive effect in the capsaicin and glutamate tests. In hippocampal slices, LEO inhibited the population spike generated by stimulation of the hylus (antidromic stimulation), with an IC50 of 0.1±0.05 mg/mL. This response was reversibly blocked by lidocaine (0.5 mg/mL), a known voltage-dependent sodium channel antagonist and by LIN (0.5 mg/mL). Our results suggest that LEO and LIN modulate neurogenic and inflammatory pain in the tests of orofacial nociception induced by formalin, capsaicin and glutamate. Part of these effects may be associated with decreased peripheral and central neuronal excitability.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach

Venâncio¹,

Marchioro²,

Estavam³

et al. 2011

Rev. bras. farmacogn.

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“…Available evidence indicates that linalool could produce antinociception through interactions with opioid, muscarinic M2 or adenosine A1 receptors and nitric oxide (NO) synthesis (22,(24)(25)(26). In addition to these pharmacological data, there are also findings supporting the modulation of glutamatergic neurotransmission through N-methyl-d-aspartate (NMDA) receptors by linalool, both in vitro and in vivo (1,4,7,8,31). Recently, we reported that intraplantar linalool administration reduced the nociceptive response as assayed by the capsaicin test.…”

Section: Discussionmentioning

confidence: 99%

Intraplantar injection of linalool reduces paclitaxel-induced acute pain in mice

et al. 2012

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Linalool is the principal component of many essential oils known to possess biological activities. We previously reported that intraplantar injection of linalool reduces the nociceptive response as assayed by the capsaicin test. In this study, we sought to determine whether intraplantar injection of linalool could influence the induction of acute pain (allodynia and hyperalgesia) by paclitaxel in mice. Paclitaxel is widely used in cancer chemotherapy for the treatment of solid tumors, but it sometimes induces moderate to severe acute pain. Paclitaxel administered intraperitoneally as a single dose of 5, 10 or 20 mg/kg produced mechanical allodynia and hyperalgesia in mice. Paclitaxel-induced mechanical allodynia and hyperalgesia began 1 day after administration of paclitaxel and resolved within 7 days. Linalool injected into the hindpaw caused a significant reduction in paclitaxel-induced mechanical allodynia and hyperalgesia. Pretreatment with naloxone hydrochloride, an opioid receptor antagonist, or naloxone methiodide, a peripherally acting μ-opioid receptor-preferring antagonist, significantly reversed linalool-induced antiallodynia and antihyperalgesia. Our results provide evidence for the involvement of peripheral opioids in antiallodynia and antihyperalgesia induced by linalool. These results suggest that activation of peripheral opioid receptors may play an important role in reducing paclitaxel-induced mechanical allodynia and hyperalgesia.The major classes of antineoplastic agents-the vinca alkaloids, taxanes, bortezomib and platinum-derived compounds-are associated with the development of dose-limiting neuropathic pain (12, 32). Paclitaxel is a taxane chemotherapeutic commonly used for the treatment of solid tumors and ovarian and breast cancers. Paclitaxel acts as an antimitotic by stabilizing microtubules against disassembly, thus inhibiting the cell cycle in late mitosis and ultimately inducing apoptosis (30). Peripheral neuropathy sometimes occurs as a side-effect of chemotherapeutic treatment with paclitaxel and often manifests as bilateral pain in the extremities in a stocking and glove-type distribution (5). This pain can greatly reduce patients' quality of life and affect activities of daily living. Furthermore, paclitaxel therapy often results in acute pain (16,21). Acute pain begins 1-3 days after the commencement of treatment with paclitaxel, resolves within 7 days and affects mostly the large axial muscular and joint regions (15). Paclitaxel-induced acute pain following paclitaxel infusion has commonly been treated with nonsteroidal antiinflammatory drugs, acetaminophen and opioid pain medications (15). In addition, ShakuyakuKanzo-To (a Japanese herb) (11), corticosteroids (17), antihistamines (18), opioids (29) and amifostine (10) have been investigated for the prevention

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“…Thus, the suppression of glutamate-induced nociception by p-cymene treatment can be associated with its interaction with the glutamatergic system (Ferreira et al, 1999). Batista et al (2008) demonstrated that linalool, a monoterpene compound prevalent in the essential oils of various aromatic plant species, possesses antinociceptive properties in mice. This effect involves peripheral and spinal sites of action and seems to be mediated by interaction with ionotropic glutamatergic-dependent mechanisms, via NMDA receptors.…”

Section: Discussionmentioning

confidence: 99%

p-Cymene reduces orofacial nociceptive response in mice

Santana¹,

Quintans‐Júnior²,

Cavalcanti³

et al. 2011

Rev. bras. farmacogn.

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This study investigated the possible antinociceptive effect of p-cymene in different tests of orofacial nociception. The animals (mice) were pretreated (i.p.) with p-cymene (25, 50, 100 mg/kg), morphine (5 mg/kg), or vehicle (0.2% Tween 80+saline), and were then subsequently administered, subcutaneously into their upper lip: formalin, capsaicin, and glutamate. The nociceptive behavior response was characterized by the time in s that the mice remained rubbing the orofacial region, for a period of 40 min in the formalin test (first phase, 0-6 min; and second phase, 21-40 min), and for 42 and 15 min in the capsaicin and glutamate tests, respectively. To verify the possible opioid involvement in the antinociceptive effects, naloxone (i.p.) was administered into the mice 15 min prior to the pretreatment with p-cymene (100 mg/kg). Finally, whether or not the p-cymene evoked any change in motor performance in the Rota-rod test was evaluated. The results showed that the treatment with p-cymene, at all doses, reduced (p<0.001) the nociceptive behavior in all nociception tests. The antinociceptive effect of p-cymene was antagonized by naloxone (1.5 mg/kg). Additionally, mice treated with p-cymene did not show any change in motor performance. In conclusion, p-cymene attenuated orofacial nociception, suggesting an involvement of the opioid system in this effect. Thus, p-cymene might represent an important biomolecule for management and/or treatment of orofacial pain.

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Evidence for the involvement of ionotropic glutamatergic receptors on the antinociceptive effect of (−)-linalool in mice

Cited by 104 publications

References 29 publications

Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach

Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach

Intraplantar injection of linalool reduces paclitaxel-induced acute pain in mice

p-Cymene reduces orofacial nociceptive response in mice

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