Evidence for the Use of Complementary and Alternative Medicine for Pelvic Inflammatory Disease: A Literature Review

Wang, Dongmei; Yue, Jiang; Feng, Jiaxing; Gao, Jingshu; Yu, Jin; Zhao, Jing; Liu, Pihong; Yaguang, Han

doi:10.1155/2022/1364297

Cited by 7 publications

(6 citation statements)

References 35 publications

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“…13,15,16 Researchers who focused on complementary therapies with natural ingredients state that various natural ingredients such as ginger, turmeric, cinnamon and bay leaves can reduce dysmenorrhoea if processed way appropriately. [17][18][19] Apart from being a therapy, the factors related to dysmenorrhoea are essential to identify the impact of interventions in therapy. From the data, the factor that can influence the occurrence of dysmenorrhoea is anxiety.…”

Section: Discussionmentioning

confidence: 99%

Complementary therapies and factors related to dysmenorrhoea in adolescents: A bibliometric analysis

Rejeki,

Pranata,

Yanto

et al. 2024

Scripta Medica

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Complementary therapies for decreasing dysmenorrhoea and factors behind dysmenorrhoea in adolescents is not clear enough. Researchers need information about trends and novelties for the future research topic of complementary therapies and factors related to dysmenorrhoea in adoles-cents. Thus, the purpose of this study was to identify the complementary therapies for decreasing dysmenorrhoea and factors related to dysmenorrhoea in adolescents by analysing network visualisation, overlay visualisation and density visualisation on the topic through bibliometric analysis. The data sources used in this study were based on online searches via https://app.dimensions.ai/. The literature search used the stages following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flowchart. Paper restricted in publications years 2014-2023, focus in the field of health sciences, nursing, public health, clinical sciences and publication type were included as criteria for inclusion in the study. The data were analysed using VOSviewer. After identifying the clusters, the types of complementary therapies that were able to reduce dysmenorrhoea were acupressure, acupuncture, calcium sufficiency, curcumin, yoga, aromatherapy, massage and physical activity. Moreover, factors related to dysmenorrhoea were HIV, reproductive coercion, reproductive health, oxytocin, prolactin, trauma, metformin, anxiety and breast cancer. Moreover, the newest topics that were being widely researched related to adolescent dysmenorrhoea were education, non-suicidal self-injury (NSSI), prolactin and physical activity. On the other hand, topics that were rarely researched related to the topic of adolescent dysmenorrhoea were topics about sexual health, reproductive coercion, inflammation, curcumin and physical activity. Complementary therapies and factors that are still rarely studied offer potential novelty in results in future studies.

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Section: Discussionmentioning

confidence: 99%

Complementary therapies and factors related to dysmenorrhoea in adolescents: A bibliometric analysis

Rejeki,

Pranata,

Yanto

et al. 2024

Scripta Medica

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“…Acupuncture and moxibustion therapy originated from the “The Yellow Emperor's Inner Classic,” having a history of more than 2,000 years. It is guided by the acupoint theory, using filiform needles and mugwort as materials and tools to achieve the purpose of preventing and treating diseases mainly by inserting thin sterile metal needles into specific areas of the body or burning cauterizing mugwort to stimulate certain parts of the body, accompanied by certain therapeutic techniques [ 89 – 91 ].…”

Section: Methodsmentioning

confidence: 99%

The Treatment of Complementary and Alternative Medicine on Female Infertility Caused by Endometrial Factors

Lin

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Recently, with the development of the social economy, the incidence of infertility has increased year by year. With its complex etiology and diversified syndromes, infertility has become one of the most important diseases that plague the physical and mental health of women of childbearing age worldwide. Endometrial factors as an important part affecting female reproductive capacity, due to which induced repeated abortion and multiple uterine cavity operations occur, can destruct endometrium, failing to provide a normal implantation environment for zygote, thus resulting in infertility. Many patients failed to achieve expected results after receiving conventional treatments such as hormone therapy, assisted reproductive technology (ART), granulocyte colony-stimulating factor (G-CSF) therapy, and cell therapy, then turn to complementary and alternative medicine (CAM) therapies for help. Aiming at clarifying the effectiveness and mechanisms of CAM therapy in the treatment of infertility caused by endometrial factors, our paper systematically searched and studied present related literature on the PubMed, CNKI, and other databases, focusing on the aspects of clinical application and mechanism explorations and highlighting the therapeutic effects of Chinese herbal medicine (CHM), acupuncture, and moxibustion on such diseases. Moreover, this paper also introduces the CAM treatments of traditional Chinese medicine (TCM) retention enema, neuromuscular electrical stimulation (NMES), photobiomodulation therapy, dietary intervention, and other measures for infertility caused by endometrial factors, in order to provide a reference for subsequent basic research and clinical work.

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“…With the rapid advancement in modern medicine, traditional Chinese medicine has drawn the attention of medical professionals and the general public worldwide (Guo et al, 2022). TCM has shown unique advantages in the treatment of numerous diseases, including PID (Zhang et al, 2017;Liu et al, 2020;Wang et al, 2022). The FUKE capsule is a modified dosage form of the FUKE tablet, a pure Chinese medicine with manufacturing approval from the National Medical Products Administration (NMPA License No.…”

Section: Introductionmentioning

confidence: 99%

A randomized, double-blind, positive-controlled, Phase-II clinical trial to evaluate efficacy and safety of Fuke Qianjin capsule in Pakistani patients with pelvic inflammatory disease

Shah,

Khan,

Fatima

et al. 2024

Front. Pharmacol.

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Ethnopharmacological relevance: Pelvic inflammatory disease (PID) is a frequently occurring gynecological disorder mainly caused by the inflammation of a woman’s upper genital tract. Generally, antibiotics are used for treating PID, but prolonged use poses potential risks of gut bacterial imbalance, bacterial resistance, super bacteria production, and associated adverse reactions. Traditional Chinese medicine (TCM) has shown unique advantages in various ailments and has received widespread clinical research attention. Fuke Qianjin (FUKE) capsule is an approved National Medical Products Administration (NMPA License No. Z20020024) Chinese herbal prescription that has been widely used individually or in combination with other Western medicines for the treatment of various gynecological inflammatory diseases, including chronic cervicitis, endometritis, and chronic PID.Aim: This clinical trial was designed to assess the safety and efficacy of FUKE capsule in mild-to-moderate symptomatic PID patients.Materials and methods: This phase 2, randomized, double-blind, positive controlled clinical trial was conducted in mild-to-moderate symptomatic PID patients at a single center in Pakistan from 21 September 2021 to 11 March 2022. Eligible female participants were randomly assigned to a test and a control group with a ratio of 1:1. The test group subjects received two metronidazole (METRO) tablets and one doxycycline hyclate (DOXY) simulant at a time, twice daily for 14 days, and two Fuke Qianjin (FUKE) capsules, three times a day after a meal for 28 days. Subjects in the control group received two METRO tablets and one DOXY tablet at a time, twice daily for 14 days, and two FUKE simulant capsules, three times a day after meal for 28 days. The primary efficacy outcome was an improvement in pelvic pain symptoms assessed through a visual analog scale (VAS). The secondary outcomes were the improvement in secondary efficacy symptoms like local physical signs, clinical assessment of leucorrhea and cervical secretions through laboratory examination, and improvement in the maximum area of pelvic effusion assessed through gynecological ultrasound after the treatment. The safety outcomes were assessed through vital signs, laboratory tests, electrocardiogram findings, and adverse events/serious adverse events.Results: A total of 198 subjects with active PID were randomly assigned to a test group (n = 99) and a control group (n = 99). The baseline characteristics of the subjects in the two groups were similar. In the intention-to-treat analysis, the primary efficacy was 84.9% for the test group and 71.6% for the control group, with a statistically significant difference (p = 0.0370; 95% CI −0.2568 to −0.0088). The secondary clinical efficacy was 88.4% for the test group and 82.7% for the control group, with no significant difference (p = 0.2977; 95% CI −0.1632 to 0.0501). The improvement in local physical signs was 95.8% for the test group and 76.9% for the control group, with no significant difference (p = 0.0542; 95% CI −0.3697 to −0.0085). The inter-group non-inferiority comparison showed that the upper limit of the 95% CI was less than 0.15 and thus met the non-inferiority requirements of the test group to the control group. The results of clinical signs of leucorrhea and cervical secretions showed that there was no difference in the rate of improvement between the test and control groups, indicating that FUKE was non-inferior to DOXY. A total of 14 adverse events in eight subjects were observed in the trial, with an incidence rate of 4.7%. Four subjects in each group experienced seven adverse events with 4.5% and 4.8% incidence rates of adverse reactions in the test and control groups, with no statistically significant differences (p = 0.2001). No serious adverse events occurred in the trial.Conclusion: The results of this trial indicate that the test drug (Fuke Qianjin capsule) is non-inferior to the control drug (doxycycline hyclate tablet) in treating mild-to-moderate PID patients with comparable efficacy, safety, and tolerability to the control drug.Clinical Trial Registration:www.clinicaltrials.gov, identifier NCT04723069.

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Evidence for the Use of Complementary and Alternative Medicine for Pelvic Inflammatory Disease: A Literature Review

Cited by 7 publications

References 35 publications

Complementary therapies and factors related to dysmenorrhoea in adolescents: A bibliometric analysis

Complementary therapies and factors related to dysmenorrhoea in adolescents: A bibliometric analysis

The Treatment of Complementary and Alternative Medicine on Female Infertility Caused by Endometrial Factors

A randomized, double-blind, positive-controlled, Phase-II clinical trial to evaluate efficacy and safety of Fuke Qianjin capsule in Pakistani patients with pelvic inflammatory disease

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