Evidence for the Use of Ceftiofur for Treatment of Metritis in Dairy Cattle

Reppert, Emily J.

doi:10.1016/j.cvfa.2014.11.007

Cited by 15 publications

(8 citation statements)

References 30 publications

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“…Screening the 7 publications found in the course of the second database search revealed that 4 publications had to be rejected due to exclusion criteria (Figure 1). Specifically, the newly retrieved publications included 1 review found in both databases (Reppert, 2015), 1 case study (Chaudhari et al, 2012), and 1 publication already found in PubMed in May 2014 but referenced belatedly in CAB (Nak et al, 2011). The remaining 3 publications (containing 1 trial each) and the 23 trials selected previously resulted in 26 trials available for meta-analytic investigations.…”

Section: Inclusion and Exclusion Criteriamentioning

confidence: 99%

Antibiotic treatment of metritis in dairy cows—A meta-analysis

Haimerl

Arlt

Borchardt

et al. 2017

Journal of Dairy Science

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The objective of this meta-analysis was to assess the efficacy of the treatment of bovine metritis with common antibiotic and nonantibiotic treatment options. Acute puerperal metritis, a systemic and potentially painful illness with rectal temperature >39.5°C and signs of toxemia due to an infection of the uterus, occurs within 21 d after parturition. Because of the infectious nature, antibiotics are considered beneficial for the treatment of acute puerperal metritis. Each use of an antimicrobial drug, however, is associated with selective pressure for eventual emergence of resistant bacteria. The 23 trials evaluated in the course of a previously conducted systematic review were the basis for meta-analytic investigations. Selected trials were screened regarding their eligibility for the following investigations: (1) comparison of different antibiotic treatments with respect to metritis prevalence at time of re-examination, (2) efficacy of ceftiofur treatment with respect to metritis prevalence at time of re-examination, (3) comparison of efficacy of antibiotic versus nonantibiotic drugs with respect to metritis prevalence at time of re-examination, and (4) equivalence assessment of treatment effects on reproductive performance measures. Where at least 3 trials had investigated the same outcome variable and met the inclusion criteria (inclusion of a control or reference group diagnosed with metritis; reporting means and standard deviation in case of continuous data), meta-analytic investigations were carried out. Due to a shortage of comparable studies, we could not conduct investigations (1) and (3). Ceftiofur treatment of 828 metritic cows was associated with a decrease in the prevalence of metritis following treatment in comparison to 804 untreated cows. In conclusion, meta-analytic investigations uncovered a need for more high-quality studies. Furthermore, a positive effect of the most commonly used antibiotic drug, ceftiofur, for the treatment of bovine metritis could be shown. A comparison with other antibiotic or nonantibiotic treatment options could not be made.

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Section: Inclusion and Exclusion Criteriamentioning

confidence: 99%

Antibiotic treatment of metritis in dairy cows—A meta-analysis

Haimerl

Arlt

Borchardt

et al. 2017

Journal of Dairy Science

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“…The improvement in most of our measures in the days following diagnosis, irrespective of meloxicam treatment, was likely explained by the effect of ceftiofur, an antimicrobial approved for metritis treatment in dairy cows (Haimerl and Heuwieser, 2014;Reppert, 2015;Haimerl et al, 2017). To our knowledge, no pharmacological studies have investigated interactions between ceftiofur and meloxicam, although the combination of ceftiofur and another NSAID, acetyl salicylate, did not alter the pharmacokinetics of either drug in adult dairy cattle (Whittem et al, 1995(Whittem et al, , 1996.…”

Section: Discussionmentioning

confidence: 84%

Changes in feeding, social, and lying behaviors in dairy cows with metritis following treatment with a nonsteroidal anti-inflammatory drug as adjunctive treatment to an antimicrobial

Lomb

Neave

Weary

et al. 2018

Journal of Dairy Science

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Dairy cows with metritis display sickness behaviors, and nonsteroidal anti-inflammatory drugs (NSAID) have the potential to reduce these responses. The objective of this study was to investigate changes in feeding, social, and lying behaviors in dairy cows with metritis that had been treated with the NSAID meloxicam. After parturition, cows were housed in a dynamic, mixed-parity group of 20 animals with access to 12 electronic feed bins, 2 electronic water bins, and 24 lying stalls in a freestall pen. Every third day after parturition, vaginal discharge was evaluated to diagnose metritis based on the presence of foul smell and characteristic visual appearance. When diagnosed with metritis, animals (n = 87) were randomly allocated to receive either a single dose of meloxicam (0.5 mg/kg of body weight subcutaneously) or a placebo solution. All metritic animals received an antimicrobial (ceftiofur) for 5 d. We measured feeding and social behaviors at the feed bunk, as well as lying behaviors, and assessed within-cow changes from the day before to the day of (d 0) NSAID treatment, and from the day before to d 1 to 5 after treatment. Generally, behaviors changed around the day of diagnosis of metritis. Compared with the placebo group, cows that received meloxicam had a greater increase in the number of visits to the feeder, but tended to show less of an increase in dry matter intake and feeding time. These differences did not persist beyond 24 h after NSAID treatment. We observed no differences in changes in number of meals and feeding rate on d 0, but from d 1 to 5 cows treated with meloxicam had a lesser decrease in the number of meals and tended to have a greater decrease in feeding rate than did placebo-treated cows. In multiparous cows on d 0 and from d 1 to 5, meloxicam treatment was associated with decreased lying times. In primiparous cows, lying time changes were similar between treatments on d 0, but lying times increased more on d 1 to 5 for meloxicam than for placebo cows. Overall, cows changed the number of lying bouts on d 0, and this increase tended to be smaller for the meloxicam cows. There were no treatment differences in changes of social behavior. In summary, we observed inconsistent and generally small effects of a single dose of meloxicam in addition to antimicrobial therapy on the behavior of cows with metritis.

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“…cephalosporin) without withdrawal time and reports of significant improvement in cure rates after their use [19]. However, a critical review of treating APM with ceftiofur concludes that lack of negative control groups and small samples sizes for some of the studies limits the scientific basis for this treatment [29]. One study found no significant effect of treatment with ceftiofur vs. animals treated with procaine penicillin G [16].…”

Section: Discussionmentioning

confidence: 99%

A longitudinal cohort study of acute puerperal metritis cases in Swedish dairy cows

et al. 2016

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BackgroundAcute puerperal metritis affects cows during the early postpartum period and causes fever, fetid vaginal discharge and general depression. The disease is severe and treatment with antimicrobials is often required. This study followed 79 Swedish dairy cows with acute puerperal metritis with registered treatment and outcome in terms of recovery. Bacteria isolated from the uterus and their susceptibility to penicillin were studied. Clinical cases were assigned by participating practitioners who examined the cows, performed uterine swab sampling, decided treatment and provided information about cow health and calving conditions. Fertility and culling data were collected from the official Swedish milk and health recording scheme. Recovery from disease was defined in four levels; as a cow that survived 1 or 4 months, was inseminated and subsequently became pregnant. Intervals from dates of first and latest calving to insemination date were studied.ResultsThe most common bacterial findings were a mixed culture of Escherichia coli and bacteria such as Gram positive cocci, Fusobacterium necrophorum, Clostridium spp. or Trueperella pyogenes. The Gram positive cocci, Pasteurella spp. and F. necrophorum were generally susceptible to penicillin. The majority of cows (70%) were treated with penicillin in accordance with the Swedish policy on treatment of metritis while 19% were treated with tetracycline and 8% were not treated with antimicrobials. Recovery rates were similar between treatments. Besides “calving to last insemination” interval (CLI) that was 5 days shorter than the national mean, fertility was slightly reduced compared to national means. “Calving to first insemination” interval (CFI) was 4 days longer than national mean and number of inseminations/cow increased from 1.9 to 2.1. Escherichia coli culture positive cows did not become pregnant to the same extent as cows without E. coli in the uterus (P = 0.046). Twin births resulted in a longer CFI (P = 0.034). The culling rate was generally high (42% within 300 days after occurrence of metritis), though death associated with acute disease was low (6%).Conclusions Escherichia coli was the most common bacterial pathogen isolated from cases of acute puerperal metritis in the present study. This bacterium is inherently resistant to penicillin, but although most cows were treated with penicillin, death due to acute disease was low and recovery and final fertility results were acceptable. In times of emerging antimicrobial resistance and demand for prudent antimicrobial use, we suggest that penicillin is a “good enough” choice if antimicrobial treatment of acute puerperal metritis is needed.Electronic supplementary materialThe online version of this article (doi:10.1186/s13028-016-0257-9) contains supplementary material, which is available to authorized users.

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Evidence for the Use of Ceftiofur for Treatment of Metritis in Dairy Cattle

Cited by 15 publications

References 30 publications

Antibiotic treatment of metritis in dairy cows—A meta-analysis

Antibiotic treatment of metritis in dairy cows—A meta-analysis

Changes in feeding, social, and lying behaviors in dairy cows with metritis following treatment with a nonsteroidal anti-inflammatory drug as adjunctive treatment to an antimicrobial

A longitudinal cohort study of acute puerperal metritis cases in Swedish dairy cows

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