Evidence for transmission of the zoonotic apicomplexan parasite Babesia duncani by the tick Dermacentor albipictus

Swei, Andrea; O'Connor, Kerry; Couper, Lisa I.; Thekkiniath, Jose; Conrad, Patricia A.; Padgett, Kerry A.; Burns, Joseph E.; Yoshimizu, Melissa Hardstone; Gonzales, Ben J.; Munk, Brandon; Shirkey, Nicholas J.; Konde, Lora; Mamoun, Choukri Ben; Lane, Robert S.; Kjemtrup, Anne

doi:10.1016/j.ijpara.2018.07.002

Cited by 59 publications

(55 citation statements)

References 35 publications

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“…Although the first reported case of human babesiosis caused by B. duncani was described in 1991 (13), the vector that transmits this parasite and the reservoir host have only recently been discovered (22). Furthermore, our understanding of the biological processes that control its pathophysiology and virulence ACCELERATED COMMUNICATION: In vitro culture of B. duncani remain unknown.…”

Section: Discussionmentioning

confidence: 99%

“…In Golden Syrian hamsters, B. duncani causes acute disease and death within 10 days of inoculation (21). Recent studies have identified Dermacentor albipictus as the main vector of B. duncani transmission, with the mule deer being the main mammalian host (22). The one-host life cycle of D. albipictus may account for the low incidence of B. duncaniassociated babesiosis cases reported so far.…”

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confidence: 99%

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Establishment of a continuous in vitro culture of Babesia duncani in human erythrocytes reveals unusually high tolerance to recommended therapies

Abraham

Brasov

Thekkiniath

et al. 2018

Journal of Biological Chemistry

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by guest on July 10, 2020 http://www.jbc.org/ Downloaded from Figure 1. Continuous in vitro culture of B. duncani in hamster RBCs and transfer to human RBCs. A, parasitemia expressed as the percentage of hamster RBCs infected by the parasite at 1, 2, and 3 days post-inoculation (DPI) in a representative experiment. Columns represent mean Ϯ S.E. (error bars) of six biological replicates. B, micrograph of the intracellular development of cultured B. duncani in hamster RBCs in a Giemsa-stained smear prepared at 3 days post-inoculation. The parasitemia was 15% in this sample. C, transfer of B. duncani to human RBCs. B. duncani-infected hamster RBCs (haRBCs) were freshly harvested and maintained in culture in the presence of human RBCs (hRBCs). Left, free merozoites and infected haRBCs. Right, successful development of B. duncani in hRBCs. Human RBCs are distinguishable from haRBCs by their larger size and darker staining. ACCELERATED COMMUNICATION: In vitro culture of B. duncani

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Establishment of a continuous in vitro culture of Babesia duncani in human erythrocytes reveals unusually high tolerance to recommended therapies

Abraham

Brasov

Thekkiniath

et al. 2018

Journal of Biological Chemistry

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“…Rare cases of autochthonous babesiosis have been reported in Washington, 3 caused by Babesia duncani and 1 caused by a B. divergens-like organism (13)(14)(15). Evidence of D. albipictus ticks as the vector for B. duncani has only recently emerged (16).…”

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confidence: 99%

Ecology and Epidemiology of Tickborne Pathogens, Washington, USA, 2011–2016

Dykstra¹,

Oltean²,

Kangiser³

et al. 2020

Emerg. Infect. Dis.

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“…Until recently, the recognized vectors for B. duncani were Ixodes species, including I. scapularis and I. pacificus. A new study provided strong support for the winter tick, Dermacentor albipictus, and the mule deer as the respective vector and host species of B. duncani, suggesting that the pathogen might have a wider geographical distribution [114]. Lastly, a third species close to Babesia divergens has been detected sporadically in patients in the USA [113,115,116].…”

Section: Protozoanmentioning

confidence: 98%

Emerging tick-borne pathogens of public health importance: a mini-review

Rochlin

Toledo

2020

Journal of Medical Microbiology

222

130

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Ticks are the most important vectors of human pathogens, leading to increased public health burdens worldwide. Tick-borne pathogens include viruses (e.g. tick-borne encephalitis and Powassan); bacteria, such as the causative agents of Lyme disease, spotted fever rickettsiosis and human anaplasmosis; and malaria-like protozoan parasites causing babesiosis. Tick-borne diseases are emerging due to the geographical expansion of their tick vectors, especially in the northern hemisphere. Two examples of this phenomenon are Ixodes scapularis and Amblyomma americanum, which have expanded their ranges in the USA in recent decades and are responsible for the continuous emergence of Lyme disease and human ehrlichiosis, respectively. This phenomenon is also occurring worldwide and is reflected by the increasing number of tick-borne encephalitis and haemorrhagic fever cases in Europe and Asia. In this review, we provide a concise synopsis of the most medically important tick-borne pathogen worldwide, with a particular emphasis on emerging public health threats.

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Evidence for transmission of the zoonotic apicomplexan parasite Babesia duncani by the tick Dermacentor albipictus

Cited by 59 publications

References 35 publications

Establishment of a continuous in vitro culture of Babesia duncani in human erythrocytes reveals unusually high tolerance to recommended therapies

Establishment of a continuous in vitro culture of Babesia duncani in human erythrocytes reveals unusually high tolerance to recommended therapies

Ecology and Epidemiology of Tickborne Pathogens, Washington, USA, 2011–2016

Emerging tick-borne pathogens of public health importance: a mini-review

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