Evidence for tryptophan hydroxylase and hydroxy-indol-o-methyl-transferase mRNAs in human blood platelets

Champier, Jacques; Bruno, Claudio; Besançon, Roger; Eymin, Cécile; Killer, Charlotte; Jouvet, Anne; Chamba, G.; Fèvre‐Montange, Michelle

doi:10.1016/s0024-3205(97)00234-8

Cited by 49 publications

(30 citation statements)

References 20 publications

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“…Very weak HIOMT activity has also been described in the duodenum and colon, probably in the enterochromaffin cells (Quay and Ma, 1976), in the human retinoblastoma Y79 cell line (Bernard et al, 1995, and in ovaries (Itoh et al, 1997). RT-PCR experiments have also shown the presence of HIOMT mRNA in human platelets (Champier et al, 1997) and the testis (Poirel and Gauer, personal communication).…”

Section: Multiple Regulation Of Pineal Melatonin Synthesis In Mammalsmentioning

confidence: 95%

Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

2003

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Section: Multiple Regulation Of Pineal Melatonin Synthesis In Mammalsmentioning

confidence: 95%

Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

2003

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“…Although melatonin is synthesized primarily in the pineal gland, synthesis also occurs in other organs and tissues such as the eye [22][23][24], skin [25], gastrointestinal tract [26,27], lymphocytes [28], platelets [29] and bone marrow [30].…”

Section: Pineal Gland and Melatonin: Biosynthesismentioning

confidence: 99%

Melatonin, environmental light, and breast cancer

Srinivasan

Spence

Pandi-Perumal

et al. 2007

Breast Cancer Res Treat

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Although many factors have been suggested as causes for breast cancer, the increased incidence of the disease seen in women working in night shifts led to the hypothesis that the suppression of melatonin by light or melatonin deficiency plays a major role in cancer development. Studies on the 7,12-dimethylbenz[a]anthracene and N-methyl-N-nitrosourea experimental models of human breast cancer indicate that melatonin is effective in reducing cancer development. In vitro studies in MCF-7 human breast cancer cell line have shown that melatonin exerts its anticarcinogenic actions through a variety of mechanisms, and that it is most effective in estrogen receptor (ER) alpha-positive breast cancer cells. Melatonin suppresses ER gene, modulates several estrogen dependent regulatory proteins and pro-oncogenes, inhibits cell proliferation, and impairs the metastatic capacity of MCF-7 human breast cancer cells. The anticarcinogenic action on MCF-7 cells has been demonstrated at the physiological concentrations of melatonin attained at night, suggesting thereby that melatonin acts like an endogenous antiestrogen. Melatonin also decreases the formation of estrogens from androgens via aromatase inhibition. Circulating melatonin levels are abnormally low in ER-positive breast cancer patients thereby supporting the melatonin hypothesis for breast cancer in shift working women. It has been postulated that enhanced endogenous melatonin secretion is responsible for the beneficial effects of meditation as a form of psychosocial intervention that helps breast cancer patients.

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“…Although there is evidence that melatonin is synthesized in multiple areas of the human body, including the bone marrow, gut, skin, platelets, and retina, most of the body’s melatonin is synthesized and secreted by the pineal gland (Cagnacci 1996; Champier et al 1997; Conti et al 2000; Slominski et al2008). Melatonin secretion is regulated by the endogenous circadian clock, the suprachiasmatic nucleus, and entrained by daily light–dark cycles with increased production occurring during darkness (Cardinali and Pevet 1998).…”

Section: Introductionmentioning

confidence: 99%

Relation of Melatonin to Sleep Architecture in Children with Autism

Leu

Beyderman

Botzolakis

et al. 2010

J Autism Dev Disord

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Children with autism often suffer from sleep disturbances, and compared to age-matched controls, have decreased melatonin levels, as indicated by urine levels of the primary melatonin metabolite, 6-sulfatoxymelatonin (6-SM). We therefore investigated the relationship between 6-SM levels and sleep architecture in children with autism spectrum disorders (ASD). Twenty-three children, aged 4–10 years, completed two nights of polysomnography and one overnight urine collection for measurement of urinary 6-SM excretion rate. Parents completed the Children’s Sleep Habits Questionnaire. We found that higher urinary 6-SM excretion rates were associated with increased N3 sleep, decreased N2 sleep, and decreased daytime sleepiness. The results warrant further examination to examine the effects of supplemental melatonin on sleep architecture and daytime sleepiness.

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Evidence for tryptophan hydroxylase and hydroxy-indol-o-methyl-transferase mRNAs in human blood platelets

Cited by 49 publications

References 20 publications

Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

Melatonin, environmental light, and breast cancer

Relation of Melatonin to Sleep Architecture in Children with Autism

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